Objectives: The aim of this study was to determine health-related quality of life among patients with osteoporosis treated with denosumab through a questionnaire. Subjects and methods: The study included 50 patients from the Department of Internal Medicine. They are all diagnosed with osteoporosis and are treated with denosumab. Data were collected by reviewing medical records and conducting a survey questionnaire. The respondents were interviewed by telephone, because due to the pandemic caused by the new SARS-CoV-2 virus, we did not want to expose the patient to the risk of developing an infection. Results: The largest number of respondents subjectively rated their health as good (84%), while a smaller number rated it as excellent (10%), and the smallest as poor (6%). Examining the association between physical disability and the need for adjustment, the existence of a positive and statistically significant association was found, as well as the relationship between age and the need for adjustment, and fear and physical disability. Fear and the need for adjustment are not statistically significantly related. A positive correlation was found between the values of densitometric measurement of the lumbar spine and age. Examination of the association between the values of densitometric measurement of the femur and age, fear, physical ability, and adjustment did not establish the existence of an association. The level of fear was higher in the observed patients who did not have comorbidities compared to the level of fear in patients who had comorbidities, while the examination did not determine the existence of a difference. Physical capacity was higher in the observed patients who did not have comorbidities compared to patients who had comorbidities, while the examination did not establish the difference. The level of adjustment is higher in the observed patients who do not have comorbidities compared to the patients who have comorbidities, while the examination did not establish the existence of a difference. Conclusions: We did not prove a difference in the quality of health in subjects with osteoporosis who have comorbidities compared to subjects who do not.