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master's thesis
Serumska koncentracija vitamina D u oboljelih od oralnog lichen planusa
2021. urn:nbn:hr:171:781213
Draganja, Mirna
University of Split
School of Medicine
Oral medicine and parodonthology

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Draganja, M. (2021). Serumska koncentracija vitamina D u oboljelih od oralnog lichen planusa (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:781213

Draganja, Mirna. "Serumska koncentracija vitamina D u oboljelih od oralnog lichen planusa." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:781213

Draganja, Mirna. "Serumska koncentracija vitamina D u oboljelih od oralnog lichen planusa." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:781213

Draganja, M. (2021). 'Serumska koncentracija vitamina D u oboljelih od oralnog lichen planusa', Master's thesis, University of Split, School of Medicine, accessed 14 December 2024, https://urn.nsk.hr/urn:nbn:hr:171:781213

Draganja M. Serumska koncentracija vitamina D u oboljelih od oralnog lichen planusa [Master's thesis]. Split: University of Split, School of Medicine; 2021 [cited 2024 December 14] Available at: https://urn.nsk.hr/urn:nbn:hr:171:781213

M. Draganja, "Serumska koncentracija vitamina D u oboljelih od oralnog lichen planusa", Master's thesis, University of Split, School of Medicine, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:171:781213

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Metadata
TitleSerumska koncentracija vitamina D u oboljelih od oralnog lichen planusa
Title (english)Analysis of vitamin D levels in patients with oral lichen planus
AuthorMirna Draganja
MentorLivia Cigić (mentor)
Committee memberAntonija Tadin (predsjednik povjerenstva)
Committee memberLidia Gavić (član povjerenstva)
Committee memberIvan Galić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Oral medicine and parodonthology)
Split
Defense date and country2021, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Oral Medicine
Abstract
Ciljevi: Ciljevi ovog istraživanja bili su ispitati postoji li razlika u vrijednostima serumske koncentracije vitamina D između ispitanika oboljelih od OLP-a i ispitanika bez patoloških promjena na sluznici usne šupljine te ispitati postoje li razlike u pacijenata s različitim kliničkim formama OLP-a. Materijali i metode: Anamnestički su od svakog ispitanika (n = 68) uzeti podatci o dobi, spolu i navici svakodnevnog pušenja cigareta. Uzorci krvi izvađeni su svakom od ispitanika kako bi se odredile vrijednosti vitamina D u krvi. Ispitnu skupinu činila su 34 ispitanika s dijagnozom OLP-a (od čega 28 s erozivnim i 6 s ne erozivnim oblikom), a kontrolnu skupinu činila su 34 ispitanika bez patoloških promjena na oralnoj sluznici. Rezultati: Rezultati su potvrdili statistički značajnu razliku u razini serumskog vitamina D između zdravih ispitanika i onih s dijagnosticiranim erozivnim oblikom OLP (p=0,045). Nije nađena statistički značajna razlika između koncentracija vitamina D u serumu ispitanika s erozivnim u odnosu na ne erozivni oblik kao ni između zdravih ispitanika i onih s ne erozivnim oblikom OLP. Vrijednosti vitamina D u serumu su pokazali statistički značajnu razliku između razine vitamina D u OLP populaciji koja je razvila karcinom u odnosu na OLP populaciju bez karcinoma (p=0,013) te između OLP populacije koja je razvila karcinom i zdrave populacije (p=0,0004). Zaključci: Temeljem dobivenih rezultata može se zaključiti kako postoji značajna razlika u razini vitamina D između zdrave kontrolne skupine i one kod koje je dijagnosticiran OLP. Točan mehanizam povezanosti vitamina D i OLP-a i dalje ostaje nepoznanica. Potrebna su buduća istraživanja na većem uzorku kako bi se utvrdila njihova povezanost. Buduća istraživanja o koncentraciji vitamina D u serumu oboljelih od OLP-a također su potrebna kako bi se potvrdili rezultati ovog istraživanja.
Abstract (english)
Objectives: The aim of this study was to examine whether there is a difference in the values of serum vitamin D concentration between subjects with OLP and subjects without pathological changes in the oral mucosa. Materials and Methods: Patient medical data (OLP and control group) included age, gender, and smoking status were taken from each respondent (n = 68). Blood samples were taken from each of the subjects to determine the levels of vitamin D in the blood. The study group consisted of 34 subjects diagnosed with OLP (of which 28 with erosive and 6 those with non-erosive form), and the control group consisted of 34 subjects without pathological changes in the oral mucosa. Results: The results confirmed a statistically significant difference in serum vitamin D levels between healthy subjects and those diagnosed with the erosive form of OLP (p = 0.045). No statistically significant difference was found between the serum concentrations of vitamin D in subjects with erosive versus non-erosive form as well as between healthy subjects and those with non-erosive form of OLP. Serum vitamin D values showed a statistically significant difference between the level of vitamin D in the OLP population that developed cancer compared to the OLP population without cancer (p = 0.013) and between the OLP population that developed cancer and healthy population (p = 0, 0004). Conclusions: Based on the obtained results, it can be concluded that there is a significant difference in the level of vitamin D between the healthy control group and the one diagnosed with OLP. The exact mechanism of binding of vitamin D and OLP remains unknown. Future research on a larger sample is needed to determine their association. Future studies on the serum vitamin D concentration of OLP patients are also needed to confirm the results of this study.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:781213
Study programmeTitle: Dental Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2021-07-23 09:19:49