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master's thesis
UČINAK BIOLOŠKE TERAPIJE NA RAZINU SERUMSKIH URATA U PSORIJATIČNOM ARTRITISU
2021. urn:nbn:hr:171:301261
Maleš, Maja
University of Split
School of Medicine

Cite this document

Maleš, M. (2021). UČINAK BIOLOŠKE TERAPIJE NA RAZINU SERUMSKIH URATA U PSORIJATIČNOM ARTRITISU (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:301261

Maleš, Maja. "UČINAK BIOLOŠKE TERAPIJE NA RAZINU SERUMSKIH URATA U PSORIJATIČNOM ARTRITISU." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:301261

Maleš, Maja. "UČINAK BIOLOŠKE TERAPIJE NA RAZINU SERUMSKIH URATA U PSORIJATIČNOM ARTRITISU." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:301261

Maleš, M. (2021). 'UČINAK BIOLOŠKE TERAPIJE NA RAZINU SERUMSKIH URATA U PSORIJATIČNOM ARTRITISU', Master's thesis, University of Split, School of Medicine, accessed 25 May 2022, https://urn.nsk.hr/urn:nbn:hr:171:301261

Maleš M. UČINAK BIOLOŠKE TERAPIJE NA RAZINU SERUMSKIH URATA U PSORIJATIČNOM ARTRITISU [Master's thesis]. Split: University of Split, School of Medicine; 2021 [cited 2022 May 25] Available at: https://urn.nsk.hr/urn:nbn:hr:171:301261

M. Maleš, "UČINAK BIOLOŠKE TERAPIJE NA RAZINU SERUMSKIH URATA U PSORIJATIČNOM ARTRITISU", Master's thesis, University of Split, School of Medicine, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:171:301261

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Metadata
TitleUČINAK BIOLOŠKE TERAPIJE NA RAZINU SERUMSKIH URATA U PSORIJATIČNOM ARTRITISU
Title (english)THE EFFECTS OF BIOLOGICAL THERAPY ON URIC ACID SERUM LEVELS IN PATIENTS WITH PSORIATIC ARTHRITIS
AuthorMaja Maleš
MentorDijana Perković (mentor)
Committee memberTina Tičinović Kurir (predsjednik povjerenstva)
Committee memberDaniela Marasović Krstulović (član povjerenstva)
Committee memberMarino Vilović (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2021-07-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Cilj istraživanja: Cilj ovog istraživanja bio je odrediti razine serumskih urata u bolesnika s psorijatičnim artritisom (PsA) prije započimanja biološke terapije te procjeniti učestalost hiperuricemije; postoji li utjecaj biološke terapije na razinu serumskih urata u bolesnika s PsA koji su liječeni biološkom terapijom na Zavodu reumatologiju i kliničku imunologiju KBC-a Split te procijeniti učinak biološke terapije na aktivnost bolesti u bolesnika s PsA. Materijali i metode: Istraživanjem je obuhvaćeno 88 bolesnika s dijagnozom PsA koji su liječeni biološkom terapijom u razdoblju od siječnja 2007. godine do 15. lipnja 2021. godine. Podaci su prikupljeni iz medicinske dokumentacije koja uključuje elektronske i klasične papirnate povijesti bolesti bolesnika koji su na biološkoj terapiji Zavoda za kliničku imunologiju i reumatologiju KBC-a Split. Rezultati: Od ukupnog broja ispitanika (N=88) bilo je 47 (53%) žena i 41 (47%) muškaraca. Ispitanici su najčešće imali od 42 do 63 godine s prosječnom dobi od 53,5 godina. 3-6 mjeseci nakon biološke terapije bilježi se sljedeće: u 90% bolesnika je došlo do pada aktivnosti bolesti mjerene DAS28 zbrojem. U 76% bolesnika smanjio se broj bolnih zglobova, a u 72% bolesnika smanjio se broj otečenih zglobova. Smanjenje osjećaja boli bilježene VAS-om bilježi se u 85% bolesnika. Vrijednost SE smanjila se u 66% bolesnika, a vrijednost CRP-a u 69% bolesnika. Arterijsku hipertenziju imalo je 60% bolesnika. Srčane bolesti imalo je 11% bolesnika, a kardiovakularni incident bilježi se u 2% bolesnika. Šećernu bolest imalo je 18% bolesnika. Smanjenje vrijednosti serumskih urata prije i nakon primijenjene biološke terapije bilježi se u 66% bolesnika. Povišenje vrijednosti urata bilježi se u 31% bolesnika. U 3% bolesnika vrijednosti serumskih urata su bile nepromijenjene. Zaključak: Potvrđeno je značajno smanjenje serumskih razina urata 3-6 mjeseci nakon primijenjene biološke terapije. Biološki lijekovi su bili učinkoviti u smanjenju parametara aktivnosti bolesti. Komorbiditeti su bili češći u naših bolesnika s PsA u odnosu na opću populaciju.
Abstract (english)
Objectives: The aim of this study was to determine the effects of biological therapy on uric acid serum levels in patients with psoriatic arthritits (PsA) on Institute of Rheumatology and clinical Immunology of University Hospital of Split. Materials and methods: The data from a group of 88 patients with PsA for the period from January 2007 to June 15 2021 was collected using hospital records and disease history. Results: Out of 88 patients with PsA included into this cross-sectional study, 47 (53%) of them were women and 41 (47%) men. The mean age of our patients was 53.5 (42-63) years. The results after 3-6 months of administering biological drugs were: DAS28 score lowered in 90% of the patients. 76% of patients had less tender joints and 72% of them had less swollen joints. 85% of patients reported less pain intensity measured by VAS. Erythrocyte sedimentation rate (ESR) dropped in 66% and CRP levels dropped in 69% of the patients. 60% patients had arterial hypertension. Heart diseases were found in 11% of the patients, while 2 % had cardiovascular incidents. 18% of the patients had diabetes mellitus. Uric acid serum levels after a 3-6 month long follow up were lowered in 66% of our patients. 31% had an increase in uric acid serum levels and for 3% of them the levels were same before and after the therapy. Conclusions: Uric acid serum levels dropped in 66% of our patients after 3-6 months of administering biological therapy. Biological therapy was efficient in lowering DAS28 score, number of tender and swollen joints and pain intensity. Our patients with PsA recorded more comorbidities than general population.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:301261
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-08-27 11:50:05