Ciljevi: Primarni ciljevi ovog diplomskog rada su odrediti učestalost osoba sa deficitom G-6-PDH u kojih je zabilježeno postojanje kliničkih ispoljenih smetnji, utvrditi o kojim je kliničkim manifestacijama riječ, te s kolikom će se zastupljenošću očitovati pojedine manifestacije i na samom kraju ispitati stupanj aktivnosti deficita aktivnosti G-6-PDH. Ispitanici i metode: Retrospektivnom analizom radova čije istraživanje je provedeno na području Srednje Dalmacije, te obrađivano u KBC Split, obuhvaćena su 183 ispitanika oba spola kod kojih je utvrđen deficit aktivnosti G-6-PDH. Rezultati: Analizom prethodnih istraživanja zabilježene su ukupno 183 osobe sa deficitom aktivnosti G-6-PDH na području Srednje Dalmacije, te u 83 (45.3 %) slučaja je zabilježeno postojanje kliničkih ispoljenih smetnji, dok je njih 100 bilo bez kliničkih manifestacija. Također je ustanovljeno da je teški deficit aktivnosti enzima (<10 %) imalo 50 ispitanika (27.3 %), dok je 133 ispitanika (72.6 %) imalo umjereni deficit aktivnosti enzima (10-60 %). Na istraživanom području deficit aktivnosti G-6-PDH se očitovao kliničkom slikom favizma u 45 slučajeva (24.6 %), dok se u nešto manjem broju očitovala zastupljenost novorođenačke hiperbilirubinemije, 38 slučajeva (20.7 %). Zaključci: Od ukupnog broja ispitanika s deficitom G-6-PDH, 83 osobe su imale kliničke manifestacije, dok ostalih 100 ispitanika nije imalo nikakvih kliničkih manifestacija. Osim kliničke slike favizma koja se očitovala u najvećeg broja ispitanika, u manjeg broja se pojavila novorođenačka hiperbilirubinemija. Što se tiče stupnja deficita aktivnosti enzima G-6-PDH, najveći broj ispitanika je imalo umjereni deficit aktivnosti enzima.

Objectives: The primary objectives of this thesis were to determine the incidence of people with a deficit of G-6-PDH in which the existence of clinical manifestations was noted; to determine which clinical manifestations were present and in what ratio and at the end to examine the degree of deficiency of G-6-PDH activity. Patients and Methods: By retrospective data analysis of researches conducted in Central Dalmatia and patients treated at University Hospital Split, we have identified 183 patients, both male and female, with established deficiency of G-6-PDH activity. Results: The analysis of previous studies reported a total of 183 people with deficiency G-6-PDH activity in Central Dalmatia, and in 83 (45.3 %) cases clinical manifestations were present, 100 of them were without clinical manifestations. It was also found that 50 subjects (27,3 %) had heavy deficit of enzyme activity (<10), while 133 patients (72.6 %) had moderate deficiency of enzyme activity (10-60 %). In 45 cases (24.6 %) deficiency of G-6 PDH activity manifested as clinical picture of favism, while smaller number manifested as neonatal hyperbilirubinemia, 38 cases (20.7 %). Conclusion: Of the total number of patients with a deficit of G-6-PDH, 83 persons had clinical manifestations, while the other 100 patients had none. The clinical features of favism manifested in the majority of subjects, while in a small number neonatal hyperbilirubinemia was present. As regards the degree of deficiency of enzyme activity, the majority of patients had a moderate deficiency of G-6 PDH activity.