Objective: The objective of this study was to assess the attitudes and knowledge of dental students of the University of Split School of Medicine regarding prosthodontics and compare the attitudes and knowledge among students of the fourth, fifth and sixth year of dental medicine study. Materials and methods: There were 93 participants included in the study. The study was conducted using anonymous and voluntary online survey in Google Forms. The questionnaire consisted of 60 questions. In the first part general data about participants as well as previously acquired clinical experience and learning perception were collected. The second part of the questionnaire examined students' attitudes about their own knowledge and skills in the field of prosthodontics and their actual knowledge of prosthodontics. Results: The total knowledge of dental students of the University of Split School of Medicine about prosthodontics was 13.24±2.8 points, with statistically significant better knowledge of the 6th year students (14.61±2.21 points) in comparison to the 4th year students (12.58 ±2.34 points) and the 5th year students (12.69±3.07 points) (P=0.004). Conclusion: The results of this study indicated insufficient knowledge of dental students of University of Split School of Medicine about prosthodontics and the lack of self-confidence in clinical skills. The results of this research can contribute to the improvement of teaching prosthodontics at the University of Split School of Medicine and show the direction of future changes in the curriculum.