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master's thesis
Mogućnosti prikupljanja konvalescentne COVID-19 plazme u Zavodu za transfuzijsku medicinu KBC Split
2021. urn:nbn:hr:171:758164
Franić, Doris
University of Split
School of Medicine

Cite this document

Franić, D. (2021). Mogućnosti prikupljanja konvalescentne COVID-19 plazme u Zavodu za transfuzijsku medicinu KBC Split (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:758164

Franić, Doris. "Mogućnosti prikupljanja konvalescentne COVID-19 plazme u Zavodu za transfuzijsku medicinu KBC Split." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:758164

Franić, Doris. "Mogućnosti prikupljanja konvalescentne COVID-19 plazme u Zavodu za transfuzijsku medicinu KBC Split." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:758164

Franić, D. (2021). 'Mogućnosti prikupljanja konvalescentne COVID-19 plazme u Zavodu za transfuzijsku medicinu KBC Split', Master's thesis, University of Split, School of Medicine, accessed 11 April 2025, https://urn.nsk.hr/urn:nbn:hr:171:758164

Franić D. Mogućnosti prikupljanja konvalescentne COVID-19 plazme u Zavodu za transfuzijsku medicinu KBC Split [Master's thesis]. Split: University of Split, School of Medicine; 2021 [cited 2025 April 11] Available at: https://urn.nsk.hr/urn:nbn:hr:171:758164

D. Franić, "Mogućnosti prikupljanja konvalescentne COVID-19 plazme u Zavodu za transfuzijsku medicinu KBC Split", Master's thesis, University of Split, School of Medicine, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:171:758164

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Metadata
TitleMogućnosti prikupljanja konvalescentne COVID-19 plazme u Zavodu za transfuzijsku medicinu KBC Split
Title (english)Possibilities of collecting convalescent COVID-19 plasma in the Department of Transfusion Medicine, University Hospital of Split
AuthorDoris Franić
MentorDejana Bogdanić (mentor)
Committee memberSlavica Dajak (predsjednik povjerenstva)
Committee memberDaniela Šupe-Domić (član povjerenstva)
Committee memberIvana Pavlinac Dodig (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2021, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract
Ciljevi istraživanja: Utvrditi mogućnost prikupljanja konvalescentne COVID-19 plazme u Zavodu za transfuzijsku medicinu KBC Split te povezanost razine titra SARS-CoV-2 IgG protutijela s vremenskim razdobljem od preboljenja COVID-19 i kliničkom slikom kod darovatelja krvi. Ispitanici i metode: Ispitanici su darovatelji krvi s preboljelim COVID-19 u anamnezi u razdoblju od 17.02.2021. do 10.05.2021. godine . U istraživanju su korišteni anamnestički podaci na liječničkom pregledu prije postupka... More uzimanja krvi i rezultati testiranja razine titra SARS-CoV-2 IgG protutijela u uzorku krvi darovatelja.Testiranje razine titra protutijela rađeno je testom MAGLUMI SARS- CoV-2 S-RBD IgG za kvantitativno određivanje SARS-CoV-2 IgG protutijela kemiluminiscentnom (CLIA) metodom pri Kliničkom zavodu za mikrobiologiju i parazitologiju i testom ARC SARS-CoV-2 IgG II Quant testom za kvalitativnu i kvantitativnu detekciju protutijela CLIA metodom pri Zavodu za transfuzijsku medicinuKBC-a Split. Rezultati: Od 17.02.2021. do 10.05.2021. godine u Zavodu za transfuzijsku medicinu KBC-a Split napravljeno je 60 testova plazme ARC SARS-CoV-2 IgG II Quant. Test je napravljen u 60 muškaraca, medijana životne dobi 38 godina. Nismo dokazali statistički značajnu razliku životne dobi ispitanika u odnosu na vrijednosti titra ( χ² = 5.0; P=0.084). Od ukupnog broja ispitanika za koje su bili dostupni podataci o kliničkoj slici (N=56) njih 55 (98%) je imalo blagu kliničku sliku. Postoji statistički značajna povezanost vremena preteklog od preboljenja COVID- 19 do doniranja plazme s vrijednostima titra (50-839; ≥840) (χ²= 4.0; P=0.046). Od ukupnog broja ispitanika njih 5 (8%) je cijepljeno jednom dozom mjesec dana prije doniranja plazme. Svih 5 cijepljenih ispitanika imalo je titar ≥840 AU/ml. U istom razdoblju pri Kliničkom zavodu za mikrobiologiju i parazitologiju KBC-a Split napravljeno je 110 testova plazme MAGLUMI SARS-CoV-2 S-RBD IgG . Test je napravljen u 110 muškaraca, medijana životne dobi 42 godine. Također nismo dokazali statistički značajnu razliku životne dobi ispitanika u odnosu na vrijednosti titra ( χ² = 5.0; P=0.075) kao i od ukupnog broja ispitanika za koje su bili dostupni podataci o kliničkoj slici (N=98) njih 89 (91%) je imalo blagu kliničku sliku. Razdioba ispitanika prema vremenu dolaska u odnosu na vrijednosti titra nije se statistički značajno razlikovala (χ²=2.5; P=0.283). Od ukupnog broja ispitanika bio je samo jedan cijepljeni jednom dozom mjesec dana prije doniranja plazme i imao je titar ≥10.05 AU/ml. Zaključci:Rezultati ovog istraživanja ukazuju da se na Zavodu za transfuzijsku medicinu može prikupljati konvalescentna COVID- 19 plazma. Ne može se dokazati statistički značajna razlika životne dobi ispitanika u odnosu na vrijednosti titra. Većina ispitanika je imala blagu kliničku sliku. Postoji statistički značajna povezanost vremena preteklog od preboljenja COVID-19 do doniranja plazme s vrijednostima titra protutijela. Less
Abstract (english)
Objectives: To determine the possibility of collecting convalescent COVID-19 plasma in the Department of Transfusion Medicine, University Hospital of Split and the relationship between the level of SARS-CoV-2 IgG antibody titer with the time period from COVID-19 recovery and the clinical picture in blood donors. Subjects and methods: Subjects were blood donors with a history of COVID-19 in the period from 17.02.2021. to 10.05.2021. year . The study used anamnestic data on a medical... More examination before the blood sampling procedure and the results of testing the level of SARS-CoV-2 IgG antibody titers in a donor blood sample. Testing the antibody titer level was performed by the MAGLUMI SARS-CoV-2 S- RBD IgG test for the quantitative determination of SARS-CoV-2 IgG antibodies by the chemiluminescent (CLIA) method at the Clinical Department of Microbiology and Parasitology and the ARC SARG II Co-II test test for qualitative and quantitative detection of antibodies by the CLIA method at the Department of Transfusion Medicine, Clinical Hospital Center Split. Results:From 17.02.2021. to 10.05.2021. 60 plasma tests of ARC SARS-CoV-2 IgG II Quant were performed in the Department of Transfusion Medicine of the Clinical Hospital Center Split. The test was done in 60 men, median age 38 years. We did not prove a statistically significant difference in the age of the subjects in relation to the titer values (χ² = 5.0; P = 0.084). Of the total number of subjects for whom clinical picture data were available (N = 56), 55 (98%) had a mild clinical picture. There is a statistically significant association of the time elapsed from COVID-19 recovery to plasma donation with titer values (50-839; ≥840) (χ² = 4.0; P = 0.046). Of the total number of subjects, 5 (8%) were vaccinated with a single dose one month before plasma donation. All 5 vaccinated subjects had a titer ≥840 AU / ml. In the same period, 110 plasma tests of MAGLUMI SARS-CoV-2 S-RBD IgG were performed at the Clinical Department of Microbiology and Parasitology of the Clinical Hospital Center Split. The test was performed in 110 men, median age 42 years. We also did not prove a statistically significant difference in the age of the subjects in relation to the titer values (χ² = 5.0; P = 0.075) as well as from the total number of subjects for whom clinical picture data were available (N = 98) 89 of them (91%) had a mild clinical picture. The distribution of subjects according to the time of arrival in relation to the titer values,significantly did not differ statistically (χ² = 2.5; P = 0.283). Of the total subjects, only one was vaccinated with a single dose one month before plasma donation and had a titer ≥10.05 AU / ml. Conclusion: The results of this study indicate that convalescent COVID-19 plasma can be collected at the Department of Transfusion Medicine. A statistically significant difference in the age of the subjects in relation to the titer values cannot be proven. Most subjects had a mild clinical picture. There is a statistically significant association of the time elapsed from COVID-19 recovery to plasma donation with antibody titer values. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:758164
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-10-11 07:04:21
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