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master's thesis
Preparati protiv ispadanja kose
sastav i mogući utjecaj na zdravlje
2021. urn:nbn:hr:171:105464
Jović, Ines
University of Split
School of Medicine

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Jović, I. (2021). Preparati protiv ispadanja kose : sastav i mogući utjecaj na zdravlje (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:105464

Jović, Ines. "Preparati protiv ispadanja kose : sastav i mogući utjecaj na zdravlje." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:105464

Jović, Ines. "Preparati protiv ispadanja kose : sastav i mogući utjecaj na zdravlje." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:105464

Jović, I. (2021). 'Preparati protiv ispadanja kose : sastav i mogući utjecaj na zdravlje', Master's thesis, University of Split, School of Medicine, accessed 03 June 2023, https://urn.nsk.hr/urn:nbn:hr:171:105464

Jović I. Preparati protiv ispadanja kose : sastav i mogući utjecaj na zdravlje [Master's thesis]. Split: University of Split, School of Medicine; 2021 [cited 2023 June 03] Available at: https://urn.nsk.hr/urn:nbn:hr:171:105464

I. Jović, "Preparati protiv ispadanja kose : sastav i mogući utjecaj na zdravlje", Master's thesis, University of Split, School of Medicine, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:171:105464

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Metadata
TitlePreparati protiv ispadanja kose : sastav i mogući utjecaj na zdravlje
Title (english)Anti-hair loss products : compositions and possible health impact
AuthorInes Jović
MentorDavorka Sutlović (mentor)
Committee memberIvana Mudnić (predsjednik povjerenstva)
Committee memberNeira Puizina Ivić (član povjerenstva)
Committee memberDavorka Sutlović (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2021-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Ciljevi istraživanja: Kvalitativnom metodom (GC-MS) odrediti sastav preparata protiv ispadanja kose te usporediti navode deklaracija s dobivenim rezultatima. Ustroj istraživanja: eksperimentalna studija Materijali i metode: Ispitana su 2 uzorka preparata protiv ispadanja kose. Za pripremu uzorka korištene su staklene Petrijeve zdjelice na koje je nanesen uzorak volumena 100 μL. Uzorci su ekstrahirani smjesom organskih otapala, kloroforma, etil acetata i N-heksana u jednakom omjeru (v/v/v= 1:1:1), te su potom postavljeni u digestor na sušenje u struji zraka. Kromatografska analiza pripremljenih ekstrakata izvedena je na plinskom kromatografu sa spektrometrom masa, metodom koja omogućava istovremeno snimanje ukupnog ionskog kromatograma (engl. Total ion chromatogram, TIC) u području od 40 – 600 m/z i snimanje samo odabranih iona (engl. Single ion monitoring, SIM). Rezultati: Kvalitativnom analizom uzoraka dobili smo rezultate koji su izlistani u analitičkom izvješću. U prvom uzorku su pronađene tvari koje nisu navedene među pomoćnim tvarima, ali prema visini signala možemo zaključiti da se radi o tvarima koje se nalaze u tragovima. U trećem uzorku nismo pronašli sve tvari koje proizvođač navodi na ambalaži, a kofein koji je jedan od sastojaka je pokazao jako visok signal što odgovara visokoj koncentraciji. Zaključak: Ovim istraživanjem je provedena samo kvalitativna analiza te bi za detaljniju obradu dobivenih podataka trebalo provesti i kvantitativnu analizu kako bi u potpunosti točno interpretirali rezultate.
Abstract (english)
Objectives: Qualitative determination of ingredients in products for hair loss using GC-MS method, as well as the comparison of the results with those declared on the product. Design: Experimental study Material and Methods: Two samples of anti-hair loss products were tested. Petri dishes were used to prepare the sample and volume of 100 μL was applied. Samples were extraced with a mixture of organic solvents, chloroform, ethyl acetate and N-hexane in equal ratio (v / v / v = 1: 1: 1), and then placed in a digester to air dry. Chromatographic analysis of the prepared extracts was performed on a gas chromatograph with a mass spectrometer, a method that allows simultaneous recording of the total ion chromatogram (TIC) in the range of 40 - 600 m / z and recording only selected ions (single ion monitoring, SIM). Results: By qualitative analysis of the samples, we obtained the results listed in the analytical report. In the first sample, substances were found that are not listed among the excipients, but according to the signal height, we can conclude that these are trace substances. In the third sample, we did not find all the substances listed by the manufacturer on the packaging, and caffeine, which is one of the ingredients, showed a very high signal, which corresponds to a high concentration. Conclusion: With this research, only a qualitative analysis was performed, and for a more detailed processing of the obtained data, a quantitative analysis should be performed in order to fully interpret the results.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:105464
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-11-05 08:56:00