| Abstract | Cilj istraživanja: Ciljevi ovog istraživanja su usporediti laboratorijske i antropometrijske parametre u bolesnika na androgen deprivirajućoj terapiji i u kontrolnoj skupini na početku i nakon 6 mjeseci od prve vizite.
Ispitanici i postupci: U istraživanju je bilo uključeno dvadeset ispitanika s nemetastatskim rakom prostate, desetorica su liječena androgen deprivirajućom terapijom, a ostalih deset su bili kontrole. Istraživanje se provodilo u dvije vizite. Prva vizita je bila prilikom uključenja u istraživanje, a druga nakon šest mjeseci. Tijekom vizite se pacijentima uzela anamneza, bilježili su se antropometrijski parametri pomoću Tanita vage te im je vađena krv kako bi se dobili laboratorijski nalazi promatranih parametara.
Rezultati: Nakon šest mjeseci od početka istraživanja se nisu našle statistički značajne razlike između ispitivane i kontrolne skupine. Međutim, pronađene su razlike unutar ispitivane skupine uspoređujući početne vrijednosti i vrijednosti izmjerene nakon šest mjeseci liječenja. Udio tjelesne masti im se povećao (P=0,005), a udio tjelesne vode smanjio (P=0,037), a masa tjelesne vode se također smanjila (P=0,039) nakon šest mjeseci liječenja. Također im se povećala vrijednost beta-crosslaps (P=0,027) te im se blago povećala koncentracija fosfata (P=0,014) unutar promatranog razdoblja. Osim toga, nakon šest mjeseci, povećali su im se i ukupni kolesterol (P=0,004), HDL (P=0,008) te LDL (P=0,004).
Zaključak: Bolesnici s nemetastatskim rakom prostate liječeni androgen deprivirajućom terapijom kroz razdolje od šest mjeseci imaju promjene u sastavu tijela, ubrzan koštani metabolizam te promjene u lipidogramu. |
| Abstract (english) | Objectives: The aim of this research was to compare laboratory and anthropometric parameters in patients treated with the androgen deprivation therapy in relation to the control group in the beginning of the trial and six months later.
Subjects and Methods: A total of twenty patients with non-metastatic prostate cancer were included in the study, of whom ten recieved androgen deprivation therapy and the rest of them were controls. This research was conducted through two visits. The first visit was at the time of the inclusion in the study. The second visit was six monthts later. During each visit their medical histories were taken, anthropometric parameters were also recorded with Tanita scale to measure body composition and their blood was drawn for the laboratory findings.
Results: After six months of the inclusion in the study, statistically significant differences were not found observing the control and the test groups. However, taking into account only the test group, we encounter statistically sigificant differences after six months of the treatment. On the one hand, in the test group, body fat content has increased (P=0.005). On the other hand, the body water mass (P=0.0391) and the body water content (P=0.037) decreased. In addition, their Beta-CrossLaps value (P=0.027) and phosphate concentration (P=0.0137) increased. Their total cholesterol (P=0.0039), HDL (P=0.0078) and LDL (P=0.0039) concentrations also increased.
Conclusions: In patients with non-metastatic prostate carcinoma after six months of treatment with the androgen deprivation therapy, there are changes in the body composition, their bone metabolism is accelerated and they have changes in their lipids concentrations in the blood samples. |
