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master's thesis
Suvremena antiglaukomska medikamentozna terapija
2023. urn:nbn:hr:171:340461
Ratković, Lucija
University of Split
School of Medicine

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Ratković, L. (2023). Suvremena antiglaukomska medikamentozna terapija (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:340461

Ratković, Lucija. "Suvremena antiglaukomska medikamentozna terapija." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:340461

Ratković, Lucija. "Suvremena antiglaukomska medikamentozna terapija." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:340461

Ratković, L. (2023). 'Suvremena antiglaukomska medikamentozna terapija', Master's thesis, University of Split, School of Medicine, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:171:340461

Ratković L. Suvremena antiglaukomska medikamentozna terapija [Master's thesis]. Split: University of Split, School of Medicine; 2023 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:171:340461

L. Ratković, "Suvremena antiglaukomska medikamentozna terapija", Master's thesis, University of Split, School of Medicine, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:171:340461

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Metadata
TitleSuvremena antiglaukomska medikamentozna terapija
Title (english)Modern anti-glaucoma drug therapy
AuthorLucija Ratković
MentorVeljko Rogošić (mentor)
Committee memberJosipa Bukić (predsjednik povjerenstva)
Committee memberLjubo Znaor (član povjerenstva)
Committee memberIvana Pavlinac Dodig (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2023-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Ophthalmology
Abstract
Objectives: We want to assess the extent to which the recommendations of the European Glaucoma Society (EGS) are followed and analyze the increase in consumption of prostaglandins (APG) and fixed therapy (FX AGL) in relation to other groups of anti-glaucoma drugs (AGL) in Split-Dalmatia County, as well as compare the state of branded and generic drugs. We are also analyzing consumption of anti-glaucoma drugs without preservatives. Materials and methods: For the purpose of this research, we collected data of the number of antiglaucoma drugs consumed from 2019 to 2022 in the area of Split-Dalmatia County by glaucoma patients. Data were collected from 36 pharmacies in the Split-Dalmatia area. Results: In this research, we showed the overall growth of AGL consumption (r=0.994, P=0.055) at a significance level of 94%. In 2022, consumption increased by 7,811 (4.75%) bottles compared to consumption in 2019. The consumption of fixed therapy increases during the study period (r=0.99, P=0.001). In 2022, it increased by 798 (16%) bottles compared to 2019. We did not prove a statistically significant linear correlation of the consumption of PGA (P=0.163) or other drugs (P=0.084) with the time of the study. Of the total number of AGL consumed (n=671539) in SplitDalmatia County from 2019 to 2022, 629817 (94%) were original medicines. The distribution of drugs by type was statistically significantly different in relation to the investigated years (χ2=1125, P<0.001). The share of generic drugs in 2022 was 1.6 times higher than in 2019. The share of original medicines in treatment ranged from 95% in 2019. to 92% in 2022. and shows a negative trend. In 2022, the share of medicines without preservatives is 26 times higher than in 2020 and 3.4 times higher than in 2021. Conclusions: We can conclude that in the Split-Dalmatia County, treatment is based on the guidelines of the European Glaucoma Society. An increase in consumption of AGL in fixed combinations and AGL without preservatives has been observed. The share of generic drugs is increasing. We have not found statistically significant linear correlation of PGA consumption with research time
Abstract (english)
Ciljevi: Želimo ispitati poštuju li se preporuke Europskog glaukomskog društva (EGS) te analizirati rast potrošnje prostaglandina (APG) i fiksne terapije (FX AGL) u odnosu na druge skupine antiglaukomskih lijekova (AGL) u Splitsko-dalmatinskoj županiji, kao i usporediti stanje originalnih i generičkih lijekova. Također pratimo potrošnju novih AGL bez konzervansa. Materijali i metode: U svrhu ovog istraživanja prikupili smo podatke o broju potrošenih antiglaukomskih lijekova od 2019. godine do 2022. godine na području Splitsko-dalmatinske županije u glaukomskih bolesnika. Podatci o nabavi antiglaukomskih lijekova dobiveni su u 36 ljekarni Splitsko-dalmatinskog područja. Rezultati: U ovom istraživanju uočen je ukupni rast potrošnje AGL (r=0,994, P=0,055) na razini značajnosti od 94%. U 2022. godini potrošnja je narasla za 7811 (4,75%) bočica u odnosu na potrošnju u 2019. godini. Potrošnja fiksne terapije raste u vremenu istraživanja (r=0,99, P=0,001). U 2022. godini porasla je za 798 (16%) lijekova u odnosu na 2019. godinu. Nismo dokazali statistički značajnu linearnu korelaciju potrošnje PGA (P=0,163) ni ostalih lijekova (P=0,084) s vremenom istraživanja. Od ukupnog broja potrošenih AGL (n=671539) u Splitsko-dalmatinskoj županiji od 2019. do 2022. godine bilo je 629817 (94%) originalnih lijekova. Razdioba originalnih i generičkih lijekova statistički se značajno razlikovala u odnosu na istraživane godine (χ2=1125, P<0,001). Udio generičkih lijekova u 2022. godini 1,6 puta je veći nego u 2019. godini. Udio originalnih lijekova u liječenju kretao se od 95% u 2019. god. do 92% u 2022. god. i pokazuje negativni trend. U 2022. godini udio lijekova bez konzervansa 26 puta je veći nego u 2020. godini i 3,4 puta veći nego u 2021. godini. Zaključci: Možemo zaključiti kako se na području Splitsko-dalmatinske županije liječenje provodi na temelju smjernica Europskog glaukomskog društva. Uočen je porast potrošnje AGL u fiksnim kombinacijama i AGL bez konzervansa. Udio generičkih lijekova je u porastu. Nije dokazana statistički značajna linearna korelacija potrošnje PGA s vremenom istraživanja.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:340461
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-07-14 08:12:52