| Abstract | Ciljevi istraživanja: Cilj ovog istraživanja bio je odrediti prevalenciju metaboličkog sindroma u osoba oboljelih od PTSP-a te ispitati razlike u socioekonomskom statusu, razini obrazovanja, antropometrijskim obilježjima, sastavu tijela, navikama te laboratorijskim parametrima između skupina pacijenata oboljelih od PTSP-a sa i bez metaboličkog sindroma.
Ispitanici i metode: U ovu je presječnu studiju uključeno 102 veterana Domovinskog rata koji boluju od PTSP-a te se liječe kroz Program oporavka od traume. Svi ispitanici studije bili su muškarci. Za vrijeme redovnih pregleda u Centru za psihotraumu, Klinike za psihijatriju Kliničkog bolničkog centra Split, od ispitanika su prikupljeni anamnestički podaci, obavljena su mjerenja sastava tijela i antropometrijska mjerenja te je uzet uzorak venske krvi. Nakon dijagnoze metaboličkog sindroma korištenjem revidiranih NCEP ATPIII kriterija, ispitanici su svrstani u dvije skupine, skupinu od 54 ispitanika s dijagnozom metaboličkim sindromom i skupina od 48 ispitanika koji nemaju metabolički sindrom.
Rezultati: Prevalencija metaboličkog sindroma iznosila je 52,9%. Od pojedinačnih sastavnica metaboličkog sindroma, najučestaliji je bio povišeni krvni tlak (65,7%), a slijedio je povišeni HbA1c (64,7%), povećani opseg struka (57,8%), povišena koncentracija triglicerida (48%), dok je najmanji broj ispitanika imao prisutnu sniženu razinu HDL kolesterola (16,7%). Skupina ispitanika s metaboličkim sindromom imala je veće razine CRP (P=0,034), HbA1c (P<0,001), ALT (P=0,003) i triglicerida (P<0,001) te manje vrijednosti HDL kolesterola (P<0,001) u usporedbi s ispitanicima bez metaboličkog sindroma. Također, ispitanici s metaboličkim sindromom imali su značajno veći ITM (P<0,001), opseg bokova (P<0,001), postotak tjelesne masti (P<0,001), metaboličku dob (P=0,007) i više mišićne mase (P<0,001) te višu razinu visceralne masti (P<0,001) u odnosu na ispitanike bez metaboličkog sindroma. Nije bilo značajne razlika među skupinama s ili bez metaboličkog sindroma u vremenu provedenom u ratu (P=0,330) i duljine trajanja psihijatrijskog liječenja (P=0,876).
Zaključak: U pacijenata oboljelih od PTSP-a pronađena je visoka prevalencija metaboličkog sindroma. Pacijenti s PTSP-om i metaboličkim sindromom imali su značajno lošije laboratorijske i antropometrijske parametre u odnosu na pacijente s PTSP-om bez metaboličkog sindroma. Pacijenti s PTSP-om nisu se razlikovali u socioekonomskom statusu, razini obrazovanja i pušenju, kao i vremenu provedenom u ratu i trajanju psihijatrijskog liječenje s obzirom na prisustvo metaboličkog sindroma. |
| Abstract (english) | Objectives: The main aim of the study was to estimate the prevalence of metabolic syndrome in patients with PTSD, and in addition, to determine the factors associated with the occurrence of metabolic syndrome, in particular education, socioeconomic status, blood parameters, anthropometric traits, body composition, duration of trauma exposure and psychiatric treatment.
Patients and methods: This cross-section study included 102 Croatian war veterans who had already been diagnosed with PTSD and treated in the University Hospital Split. The study included only male patients. For the purposes of this study participants answered questions regarding their health, smoking habits, and socioeconomic status. Furthermore, we conducted measurements of anthropometric traits, blood pressure, body composition and finally, venous blood sample was taken from each participant. After diagnosing the participants using NCEP ATPIII criteria, they were split into two groups, one including 54 participants with metabolic syndrome, and the other including 48 participants without metabolic syndrome.
Results: Investigated population (N=102) in this study showed an estimated prevalence of metabolic syndrome of 52.9%. In terms of individual components, increased blood pressure was the most common individual component present in our patients (65.9%), followed by increased HbA1c (64.7%), increased waist circumference (57.8%), increased triglyceride blood level (48%), and decreased HDL cholesterol (16.7%) level being the least common individual component of metabolic syndrome present. Group of patients with metabolic syndrome had higher levels of CRP (P=0.034), HbA1c (P<0.001), ALT (P=0.003) and triglycerides (P<0.001) and decreased level of HDL (P<0.001) in comparison with the group of patients without metabolic syndrome. In addition, participants that had metabolic syndrome had higher BMI (P<0.001), hip circumference (P<0.001), percentage of body fat (P<0.001), metabolic age (P=0.007), muscle mass (P<0.001), and visceral fat level (P<0.001). Time spent in the war (P=0.330) and the duration of psychiatric treatment (P=0.876) were not associated with the presence of metabolic syndrome in this study.
Conclusion: This study revealed a significantly higher prevalence of metabolic syndrome in patients suffering from PTSD. Patients with both PTSD and metabolic syndrome had worse laboratory and anthropometric values in comparison with patients with PTSD without metabolic syndrome. Two groups did not show differences in socioeconomic status, education, smoking habits, time spent in the war and the duration of psychiatric treatment. |
