| Abstract | Cilj istraživanja: Cilj istraživanja bio je usporediti serumske koncentracije LOX-1 između skupine neliječenih bolesnika s esencijalnom hipertenzijom i bolesnika koji se od iste liječe antihipertenzivnim lijekovima.
Materijali i metode: U istraživanje je ukupno uključeno 40 ispitanika s dijagnozom esencijalne hipertenzije. Prosječna dob ispitanika bila je 56,7 ± 9,5 godina. Od uključenih ispitanika, 20 je bilo neliječeno, dok je 20 liječeno ACE inhibitorima s ili bez tijazidnog diuretika u terapiji, ili kombinacijom ACE inhibitora s blokatorom kalcijskih kanala s ili bez tijazidskog diuretika. Arterijski tlak mjeren je pomoću uređaja WatchBP Home A. Educirani laboratorijski tehničar uzimao je 20 ml venske krvi iz kubitalne vene pomoću sterilne igle za jednokratnu upotrebu iz čega je analizirana serumska koncentracija LOX-1 i drugih laboratorijskih parametara.
Rezultati: Bolesnici koji nisu prethodno liječeni antihipertenzivnom terapijom imali su značajno veće serumske razine LOX-1 u odnosu na bolesnike koji su se od iste liječili ACE inhibitorima s ili bez blokatora kalcijskih kanala (21,2 (14,8-30,8) pg/mL vs. 9,8 (8,5-17,0) pg/mL, p = 0,015). Bolesnici s hipertenzijom prvog stupnja imali su značajno niže razine LOX1 u serumu u odnosu na bolesnike s hipertenzijom drugog stupnja 11,1 (9,2-18,4) pg/mL vs.
21,1 (11,8-30,8) pg/mL, p = 0,009). Nisu pronađene statističke značajne korelacije između serumskih koncentracija LOX-1 i serumskih razina CRP-a, indeksa tjelesne mase i LDLkolesterola. Pronađena je statistički značajna pozitivna korelacija između serumskih razina LOX-1 i prosječnog 24-satnog dijastoličkog tlaka (r = 0,660; p = 0,016).
Zaključak: Rezultati ovog istraživanja upućuju da bi LOX-1 mogao biti uključen u složenu patofiziologiju esencijalne hipertenzije, no potrebna su dodatna istraživanja na većem broju ispitanika kako bi se to potvrdilo. |
| Abstract (english) | Objectives: The aim of the study was to compare serum concentrations of LOX-1 between a group of untreated patients with essential hypertension and patients treated with antihypertensive drugs with essential hypertension.
Methods: A total of 40 subjects diagnosed with essential hypertension were included in the research. The average age of the subjects was 56.7 ± 9.5 years. Of the included subjects, 20 were untreated, while 20 were treated with ACE inhibitors with or without a thiazide diuretic
in therapy, or with a combination of an ACE inhibitor with a calcium channel blocker with or without a thiazide diuretic. Arterial pressure was measured using the WatchBP Home A device. A trained laboratory technician collected 20 ml of venous blood from the cubital vein using a
sterile disposable needle from which the serum concentration of LOX-1 and other laboratory parameters were analyzed.
Results: Patients who were not previously treated with antihypertensive therapy had significantly higher LOX-1 serum levels compared to patients who were treated with ACE inhibitors with or without calcium channel blockers (21.2 (14.8-30.8) pg/mL vs. 9.8 (8.5-17.0) pg/mL, p = 0.015). Patients with hypertension of the first stage had significantly lower levels of LOX-1 in serum compared to patients with hypertension of the second stage 11.1 (9.2 -18.4) pg/mL vs. 21.1 (11.8-30.8) pg/mL, p = 0.009). No statistically significant correlations were found between serum concentrations of LOX-1 and serum levels of CRP, body mass index and LDL-cholesterol. A statistically significant positive correlation was found between serum levels of LOX-1 and average 24-hour diastolic pressure (r = 0.660; p = 0.016).
Conclusion: The results of this study indicate that LOX-1 could be involved in the complex pathophysiology of essential hypertension, but additional research on a larger number of subjects is needed to confirm this. |
