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THE INCIDENCE OF THYROID MICROCARCINOMA IN PATIENTS TREATED FOR WELL-DIFFERENTIATED THYROID CANCER IN CLINICAL HOSPITAL CENTRE SPLIT DURING THE PERIOD 2008 - 2011
Ante Kedžo (2013)
University of Split
School of Medicine
Cite this document

Kedžo, A. (2013). UČESTALOST MIKROKARCINOMA ŠTITNJAČE U BOLESNIKA LIJEČENIH ZBOG DOBRO DIFERENCIRANIH KARCINOMA ŠTITNJAČE U KBC-u SPLIT U RAZDOBLJU 2008. - 2011. G. (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:056185

Kedžo, Ante. "UČESTALOST MIKROKARCINOMA ŠTITNJAČE U BOLESNIKA LIJEČENIH ZBOG DOBRO DIFERENCIRANIH KARCINOMA ŠTITNJAČE U KBC-u SPLIT U RAZDOBLJU 2008. - 2011. G.." Master's thesis, University of Split, School of Medicine, 2013. https://urn.nsk.hr/urn:nbn:hr:171:056185

Kedžo, Ante. "UČESTALOST MIKROKARCINOMA ŠTITNJAČE U BOLESNIKA LIJEČENIH ZBOG DOBRO DIFERENCIRANIH KARCINOMA ŠTITNJAČE U KBC-u SPLIT U RAZDOBLJU 2008. - 2011. G.." Master's thesis, University of Split, School of Medicine, 2013. https://urn.nsk.hr/urn:nbn:hr:171:056185

Kedžo, A. (2013). 'UČESTALOST MIKROKARCINOMA ŠTITNJAČE U BOLESNIKA LIJEČENIH ZBOG DOBRO DIFERENCIRANIH KARCINOMA ŠTITNJAČE U KBC-u SPLIT U RAZDOBLJU 2008. - 2011. G.', Master's thesis, University of Split, School of Medicine, accessed 21 September 2019, https://urn.nsk.hr/urn:nbn:hr:171:056185

Kedžo A. UČESTALOST MIKROKARCINOMA ŠTITNJAČE U BOLESNIKA LIJEČENIH ZBOG DOBRO DIFERENCIRANIH KARCINOMA ŠTITNJAČE U KBC-u SPLIT U RAZDOBLJU 2008. - 2011. G. [Master's thesis]. Split: University of Split, School of Medicine; 2013 [cited 2019 September 21] Available at: https://urn.nsk.hr/urn:nbn:hr:171:056185

A. Kedžo, "UČESTALOST MIKROKARCINOMA ŠTITNJAČE U BOLESNIKA LIJEČENIH ZBOG DOBRO DIFERENCIRANIH KARCINOMA ŠTITNJAČE U KBC-u SPLIT U RAZDOBLJU 2008. - 2011. G.", Master's thesis, University of Split, School of Medicine, Split, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:171:056185

Metadata
TitleUČESTALOST MIKROKARCINOMA ŠTITNJAČE U BOLESNIKA LIJEČENIH ZBOG DOBRO DIFERENCIRANIH KARCINOMA ŠTITNJAČE U KBC-u SPLIT U RAZDOBLJU 2008. - 2011. G.
Title (english)THE INCIDENCE OF THYROID MICROCARCINOMA IN PATIENTS TREATED FOR WELL-DIFFERENTIATED THYROID CANCER IN CLINICAL HOSPITAL CENTRE SPLIT DURING THE PERIOD 2008 - 2011
AuthorAnte Kedžo
MentorVinko Marković (mentor)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2013, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Cilj istraživanja: Utvrditi kolika je učestalost dobro diferenciranih mikrokarcinoma štitnjače među ispitanicima oboljelim od karcinoma štitnjače u periodu 2008.-2011.; istražiti učestalost pojedinih oblika mikrokarcinoma, udio unifokalnih i multifokalnih mikrokarcinoma te procijeniti eventualnu potrebu za primjenom radiojodne ablacije. Ustroj istraživanja:Presječno istraživanje Mjesto istraživanja: Istraživanje je provedeno u Kliničkom bolničkom centru Split na Zavodu za Nuklearnu medicinu. Hipoteze istraživanja: Ispitanici s mikrokarcinomom čine najveći broj ispitanika oboljelih od karcinoma štitnjače s tim da je među njima najveći postotak mikrokarcinoma dijagnosticiranih ultrazvukom i citološkom punkcijom. Za većinu mikrokarcinom nije potrebno provesti radiojodnu ablaciju. Ispitanici i metode: Istraživanje je provedeno kod 412 bolesnika liječenih u Zavodu za nuklearnu medicinu u promatranom razdoblju od 2008. do konca 2011. Za obradu podataka koristili smo metode filtriranja podataka, grupiranja, analiziranja i tabličnog prikazivanja. Rezultati: U promatranom razdoblju od 2008.-2011. godine dijagnosticirana su 202 papilarna mikrokarcinoma što predstavlja 57% dijagnosticiranih papilarnih karcinoma i 49% svih karcinoma štitnjače. Najveći broj, 133 ili 66%, je dijagnosticiran ultrazvukom i citološkom punkcijom. Kliničkih mikrokarcinoma, tj. mikrokarcinoma s metastazama, je dijagnosticirano 20 (10%) dok su dijagnosticirana 49 (24%) incidentaloma. Kod 45 (22%) ispitanika papilarni mikrokarcinom je bio multifokalan, tj. imao je još jedno ili više žarišta tumorskog tkiva u istom, drugom ili u oba režnja, pri čemu je multifokalnost u najvećem postotku nađena kod kliničkih mikrokarcinoma (60%). Svaki četvrti mikrokarcinom dijagnosticiran ultrazvukom i citološkom punkcijom je bio multifokalan dok je najmanji postotak multifokalnosti zabilježen među incidentalomima (4%). Zaključci: Papilarni mikrokarcinomi čine gotovo polovicu svih karcinoma štitnjače i veći dio papilarnih karcinoma. U dvije trećine slučajeva se dijagnosticiraju ultrazvukom i citološkom punkcijom i 3x su češći od incidentaloma. Klinički mikrokarcinomi čine 10% mikrokarcinoma. Radiojodna ablacija nije potrebna za unifokalne mikrokarcinome dijagnosticirane ultrazvukom i citološkom punkcijom. Glede multifokalnih mikrokarcinoma potrebno je dodatno istraživanje kako bismo došli do konačnog odgovora na pitanje o eventualnoj potrebi radiojodne ablacije.
Abstract (english)
Objective: Determine what is the frequency of well-differentiated thyroid microcarcinoma among individuals suffering from thyroid cancer in the period of 2008th-2011th; investigate the incidence of certain forms of microcarcinoma, share of unifocal and multifocal microcarcinoma and assess the possible need for applying radioiodine ablation. Design: Cross-sectional study. Settings: The study was conducted at the Clinical Hospital Centre Split in the Department of Nuclear Medicine. Hypotheses: Subjects with microcarcinoma make up the largest number of patients suffering from thyroid cancer with the highest percentage among them microcarcinoma diagnosed by ultrasound and FNAC. Most microcarcinomas do not need radioiodine ablation. Patients and Methods: We analyzed 412 patients treated in the Department of Nuclear Medicine in the period since 2008. to the end of 2011. For data processing, we used methods of data filtering, grouping and analyzing, tabular and graphical representation Results: In the period from 2008. to 2011. There were 202 papillary microcarcinoma diagnosed, which represents 57% of diagnosed papillary carcinomas and 49% of all thyroid cancers. The largest number, 133, or 66%, were diagnosed by ultrasound and FNAC. Clinical microcarcinoma, microcarcinoma with metastases, were diagnosed 20 (10%) while 49 (24%) were incidentalomas. In 45 (22%) cases of PMCT was multifocal, it had one or more foci of tumour tissue in the same, the other or both of the flap. The highest percentage of multiplicity was found in clinical microcarcinoma (60%). Every fourth microcarcinoma diagnosed by ultrasound and FNAC was multifocal while the lowest percentage of multifocal tumours was recorded among incidentaloma (4%). Conclusions: Papillary microcarcinoma makes up almost half of all thyroid cancers and much of papillary carcinoma. Two thirds of cases are diagnosed by ultrasound and FNAC and three times more common than incidental. Clinical microcarcinomas constitute 10% of microcarcinoma. Ablation is not required for unifocal microcarcinomas diagnosed by ultrasound and FNAC. Regarding multifocal microcarcinomas further research is required for the final answer to the question about the possible need for radioiodine ablation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:056185
Study programmeTitle: Medicina
Study programme type: sveučilišni
Study level: integrirani preddiplomski i diplomski
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsRestricted access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
Created on2016-05-12 11:31:43