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master's thesis
Ispitivanje učinkovitosti i sigurnosti kozmetike s niacinamidom u iritacijskom kontaktnom dermatitisu
2024. urn:nbn:hr:171:758586
Latinac, Nera-Ana
University of Split
School of Medicine

Cite this document

Latinac, N. A. (2024). Ispitivanje učinkovitosti i sigurnosti kozmetike s niacinamidom u iritacijskom kontaktnom dermatitisu (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:758586

Latinac, Nera Ana. "Ispitivanje učinkovitosti i sigurnosti kozmetike s niacinamidom u iritacijskom kontaktnom dermatitisu." Master's thesis, University of Split, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:171:758586

Latinac, Nera Ana. "Ispitivanje učinkovitosti i sigurnosti kozmetike s niacinamidom u iritacijskom kontaktnom dermatitisu." Master's thesis, University of Split, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:171:758586

Latinac, N. A. (2024). 'Ispitivanje učinkovitosti i sigurnosti kozmetike s niacinamidom u iritacijskom kontaktnom dermatitisu', Master's thesis, University of Split, School of Medicine, accessed 05 December 2024, https://urn.nsk.hr/urn:nbn:hr:171:758586

Latinac NA. Ispitivanje učinkovitosti i sigurnosti kozmetike s niacinamidom u iritacijskom kontaktnom dermatitisu [Master's thesis]. Split: University of Split, School of Medicine; 2024 [cited 2024 December 05] Available at: https://urn.nsk.hr/urn:nbn:hr:171:758586

N. A. Latinac, "Ispitivanje učinkovitosti i sigurnosti kozmetike s niacinamidom u iritacijskom kontaktnom dermatitisu", Master's thesis, University of Split, School of Medicine, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:171:758586

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Metadata
TitleIspitivanje učinkovitosti i sigurnosti kozmetike s niacinamidom u iritacijskom kontaktnom dermatitisu
Title (english)Assessing the effectiveness and safety of cosmetics with niacinamide in irritant contact dermatitis
AuthorNera-Ana Latinac
MentorJosipa Bukić (mentor)
Committee memberAna Šešelja Perišin (predsjednik povjerenstva)
Committee memberDoris Rušić (član povjerenstva)
Committee memberJosipa Bukić (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2024-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Cilj istraživanja: Cilj ovog istraživanja bio je ispitati učinkovitost i sigurnost primjene kozmetike s niacinamidom te utvrditi objektivne promjene parametara kože nakon topikalno nanešenog niacinamida, poput transepidermalnog gubitka vlage (TEWL), vlažnosti i eritema. Materijali i metode: Ovo je bilo randomizirano kontrolirano kliničko ispitivanje provedeno na Medicinskom fakultetu Sveučilišta u Splitu tijekom travnja 2024. godine. Ispitivala se učinkovitost i sigurnost kreme s niacinamidom na 24 zdrava ispitanika muškog i ženskog spola u rasponu od 21-34 godina. Svi sudionici su prije početka istraživanja potpisali informirani pristanak te su morali zadovoljiti kriterije uključenja, odnosno nisu imali kriterij isključenja (kožne bolesti, trudnoća, izlaganje UV-zračenju, itd.). Na podlakticama se inducirao kontakti dermatitis pomoću SLS-a. Krema s niacinamidom se nanosila na lijevu podlakticu ispitanika dva puta dnevno, nakon mjerenja parametara i navečer pred spavanje kroz 10 dana. Mjerenje kožnih parametara provedeno je neinvazivnom metodom pomoću uređaja MPA6 (Courage + Khazaka GmBH, Koln, Njemačka), a mjerio se transepidermalni gubitak vlage (TEWL), vlažnost kože i kožni eritem. Uz vrijednosti parametara, zabilježena su i subjektivna mišljenja ispitanika o njihovom iskustvu nanošenja kreme te eventualnim nuspojavama. Prije početka ovog ispitivanja sve sudionike se pitalo jesu li ikad imali nuspojave na neki sastojak kreme koja se koristila. Istraživanje je provedeno u kontroliranim uvjetima, s konstantnom temperaturom i vrijednosti vlage zraku. Trajalo je 11 dana te je ukupno provedeno sedam mjerenja. Rezultati: Upotreba kreme s niacinamidom dovela je do značajnog pada vrijednosti eritema u ispitivanoj skupini (220,1 ± 47,7 AU), u odnosu na kontrolnu (249,5 ± 48,8 AU). Također je zabilježeno i smanjenje vrijednosti TEWL-a. Vlažnost u ispitivanoj skupini značajno je povećana u odnosu na kontrolnu i to tijekom cijelog istraživanja. Zaključak: Istraživanje je pokazalo da krema s niacinamidom ima pozitivan utjecaj na obnovu kožne barijere nakon induciranja kontaktnog dermatitisa. Nije zaprimljena niti jedna prijava neželjene reakcije na samu kremu, stoga ju možemo smatrati sigurnom.
Abstract (english)
Objectives: The aim of this research was to examine the effectiveness and safety of using cosmetics with niacinamide, also to determine objective changes in skin parameters after topically applied niacinamide, such as transepidermal water loss (TEWL), hydration and erythema. Materials and methods: This was a randomized controlled clinical trial conducted at the University of Split School of Medicine in April 2024. The study evaluated the efficacy and safety of a niacinamide cream on 24 healthy male and female participants aged 21-34. All participants signed informed consent before the start of the study and had to meet inclusion criteria, without any exclusion criteria (such as skin diseases, pregnancy, exposure to UV radiation, etc.). On both forearms we induced contact dermatitis by SLS. The niacinamide cream was applied to the left forearm of the participants twice daily, after parameter measurements and in the evening before bedtime, for 10 days. Skin parameters were measured using a non-invasive method with the MPA6 device (Courage + Khazaka GmBH, Cologne, Germany), measuring transepidermal water loss (TEWL), skin hydration, and skin erythema. Along with parameter values, subjective opinions of the participants about their experience applying the cream and any side effects were recorded. Before the start of the study, all participants were asked if they had ever had any adverse reactions to any ingredient in the cream used. The study was conducted under controlled conditions, with constant temperature and humidity levels. It lasted for 11 days and a total of seven measurements were taken. Results: The use of the cream with niacinamide led to a significant decrease in erythema values in the test group (220.1 ± 47.7 AU), compared to the control group (249.5 ± 48.8 AU). A reduction in TEWL values was also observed. Skin hydration in the test group significantly increased compared to the control group throughout the entire study. Conclusion: The study demonstrated that the niacinamide cream has a positive impact on skin barrier recovery after the induction of contact dermatitis. No adverse reactions to the cream were reported, so it can be considered safe.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:758586
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-25 12:05:43