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doctoral thesis
Dijagnostika sarkopenije kod bolesnika s cirozom jetre primjenom bioelektrične impedancije
2025. urn:nbn:hr:171:423856
Božić, Dorotea
University of Split
School of Medicine

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Božić, D. (2025). Dijagnostika sarkopenije kod bolesnika s cirozom jetre primjenom bioelektrične impedancije (Doctoral thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:423856

Božić, Dorotea. "Dijagnostika sarkopenije kod bolesnika s cirozom jetre primjenom bioelektrične impedancije." Doctoral thesis, University of Split, School of Medicine, 2025. https://urn.nsk.hr/urn:nbn:hr:171:423856

Božić, Dorotea. "Dijagnostika sarkopenije kod bolesnika s cirozom jetre primjenom bioelektrične impedancije." Doctoral thesis, University of Split, School of Medicine, 2025. https://urn.nsk.hr/urn:nbn:hr:171:423856

Božić, D. (2025). 'Dijagnostika sarkopenije kod bolesnika s cirozom jetre primjenom bioelektrične impedancije', Doctoral thesis, University of Split, School of Medicine, accessed 24 February 2025, https://urn.nsk.hr/urn:nbn:hr:171:423856

Božić D. Dijagnostika sarkopenije kod bolesnika s cirozom jetre primjenom bioelektrične impedancije [Doctoral thesis]. Split: University of Split, School of Medicine; 2025 [cited 2025 February 24] Available at: https://urn.nsk.hr/urn:nbn:hr:171:423856

D. Božić, "Dijagnostika sarkopenije kod bolesnika s cirozom jetre primjenom bioelektrične impedancije", Doctoral thesis, University of Split, School of Medicine, Split, 2025. Available at: https://urn.nsk.hr/urn:nbn:hr:171:423856

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Metadata
TitleDijagnostika sarkopenije kod bolesnika s cirozom jetre primjenom bioelektrične impedancije
Title (english)Detection of sarcopenia in patients with liver cirrhosis using the bioelectrical impedance analysis
AuthorDorotea Božić
MentorIvana Mikolašević (mentor)
Committee memberŽeljko Puljiz (predsjednik povjerenstva)
Committee memberDijana Perković (član povjerenstva)
Committee memberAndre Bratanić (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2025-02-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Uvod: Bioelektrična impedancija (BIA, engl. bioelectrical impedance analysis) je metoda procjene sastava tijela. Cilj istraživanja bio je utvrditi njenu točnost u detekciji sarkopenije u bolesnika s cirozom jetre. Kao referentna metoda korišten je indeks skeletnog mišićnog tkiva (SMI, engl. skeletal muscle index) na razini trećeg lumbalnog kralješka (L3-SMI) dobiven korištenjem višeslojne kompjutorizirane tomografije. Ispitanici i metode: Bolesnici s cirozom jetre uključeni su u razdoblju od listopada 2019. do ožujka 2022. te su praćeni do siječnja 2023. Njihovi BIA parametri uspoređeni su s vrijednostima L3-SMI te su korištenjem ROC (engl. receiver operating characteristic curve) analize predložene granične vrijednosti BIA parametara u detekciji sarkopenije. Temeljem dobivenih kliničkih karakteristika analizirani su i ishodi bolesnika. Rezultati: Uključeno je ukupno 106 bolesnika. Pronašli smo značajnu korelaciju između BIA parametara i L3-SMI. Odredili smo granične vrijednosti od ≤11,1 kg/m2 za BIA-SMI (Se 73%, Sp 66%, AUROC 0,737, p < 0,001) i ≤5,05° za PA (Se 79%, Sp 60%, AUROC 0,762, p < 0,001) u detekciji sarkopenije. Relativni rizik od smrti bio je 2,2 puta veći u bolesnika sa skeletno-mišićnom masom (SMM, engl. skeletal muscle mass) ≤36,5 kg. SMM je ujedno pokazao značajnu povezanost s ishodima u Kaplan-Meierovoj analizi. Zaključak: Ova neinvazivna i jednostavna metoda, koja je pokazala dobre dijagnostičke mogućnosti i vrlo dobro predviđanje ishoda, mogla bi ispuniti potrebu za brzim i pristupačnim otkrivanjem sarkopenije u bolesnika s cirozom jetre.
Abstract (english)
Background: Bioelectrical impedance analysis (BIA) is a body composition assessment method. We aimed to determine its accuracy in the detection of sarcopenia in patients with liver cirrhosis (LC), using skeletal muscle index (SMI) at the level of third lumbar vertebra (L3- SMI) obtained using the multislice computed tomography as the reference method. Patients and methods: Patients with LC were enrolled in the period October 2019–March 2022 and follow-ups were conducted until January 2023. Their BIA parameters were compared against L3-SMI, and BIA cut-off values were proposed using AUROC analysis. Patients underwent outcome analysis based on obtained clinical characteristics. Results: A total of 106 patients were included. We found a fair correlation between BIA parameters with the L3-SMI.We determined cut-off values of ≤11.1 kg/m2 for BIA-SMI (Se 73%, Sp 66%, AUROC 0.737, p < 0.001) and ≤5.05° for phase angle (PA) (Se 79%, Sp 60%, AUROC 0.762, p < 0.001) in the detection of sarcopenia. The relative risk of death was 2.2 times higher in patients with skeletal muscle mass (SMM) ≤36.5 kg. SMM was significantly associated with outcome in Kaplan–Meier analysis. Conclusion: This non-invasive and simple method that showed fair performances and a very good outcome prediction could provide for the unmet need for fast and affordable detection of sarcopenia in patients with LC and should be further evaluated.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:423856
Study programmeTitle: Biology of Neoplasms
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2025-02-24 11:56:07