Title | VRIJEDNOSTI PAPA TESTA U ODREĐIVANJU DISPLAZIJA MATERNIČNOG VRATA |
Author | Rina Pejković |
Mentor(s) | Deni Karelović (thesis advisor)
|
Abstract | Cilj istraživanja. Retrospektivno ispitati pouzdanost citološke analize papa testa u
odnosu na patohistološku dijagnozu kolposkopski ciljane biopsije, te usporediti patohistološke
nalaze konizata i biopsije materničnog vrata.
Ustroj istraživanja. Retrospektivno smo analizirali podatke 106 ispitanica koje su
operirane u Klinici za ženske bolesti i porode tijekom 2011. godine. U svih ispitanica
analizirali smo sljedeće parametre: citološki nalaz papa testa, patohistološki nalaz biopsije i
patohistološki nalaz konizata. Sva tri parametra podjelili smo u dvije skupine, LSIL i HSIL
skupinu. Međusobno smo uspoređivali odnos između patohistološkog nalaza biopsije i
patohistiološkog nalaza konizata te citološkog nalaza papa testa prema patohistološkom
nalazu biopsije i patohistološkom nalazu konizata.
Mjesto istraživanja. Povjesti bolesti su dobivene iz pismohrane Klinike za ženske
bolesti i porode. Papa test je analiziran na Odjelu za Citologiju, Zavoda za patologiju,sudsku
medicinu i citologiju KBC Split. Patohistološki nalazi biopsije i konusa dobivenih
operativnim zahvatom analzirani su na Odjelu za Patologiju, Zavoda za patologiju, sudsku
medicinu i citologiju KBC Split.
Pacijenti i postupci. U rad su uključene ispitanice koje su podvrgnute operativnom
zahvatu konizacije ili LLETZ. Analizirani su podatci: dob, paritet, podatci o citološkom
nalazu papa testa, patohistološki nalaz bioptata materničnog vrata, patohistološki nalaz
konizata kao i vrsta operatvnoga zahvata. Parametri iz citološkog nalaza papa testa su
podijeljeni na skvamozne intraepitelne lezije niskog stupnja (LSIL) koje obuhvaćaju CIN I
promjene i skvamozne intraepitelne lezije visokog stupnja (HSIL) koji obuhvaćaju CIN II i
CIN III promjene. Preoperatvno je urađena kolposkopija.
Rezultati. Analiziran smo podatke 106 ispitanica. Usporedba nalaza papa testa i
patohistoloških nalaza biopsije pokazala je da među njima postoji statistički značajna
povezanost (P=0,024). Usporedba nalaza papa testa i patohistoloških nalaza konizacije
pokazala je da među njima ne postoji statistički značajna povezanost (P=0,897). Usporedba
patohistoloških nalaza biopsije i patohistoloških nalaza konizacije pokazala je da među njima
postoji statistički značajna povezanost (P=0,004).
Zaključak. Analizom citoloških nalaza papa testova zaključili smo da je papa test
pouzdana metoda u detekciji preneoplastičnih lezija materničnog vrata. Zadovoljava nas i
pouzdanost papa testa u našem ispitivanom uzorku. |
Keywords | Uterine Cervical Dysplasia Vaginal Smears |
Granter | University of Split School of Medicine |
Place | Split |
State | Croatia |
Scientific field, discipline, subdiscipline | BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Gynecology and Obstetrics
|
Study programme type | university |
Study level | integrated undergraduate and graduate |
Study programme | Medicine |
Academic title abbreviation | dr. med. |
Genre | master's thesis |
Language | Croatian |
Defense date | 2012 |
Parallel abstract (English) | Objective. To retrospectively inquire reliability of cytological analysis of pap smear in
relation to pathohistological diagnosis of colposcopicaly aimed biopsy and to compare
pathohistological results of conus and biopsy of cervix.
Design. We have retrospectivelly 106 testees who were operated in the Department of
Obstetrics and Gynecology during 2011. We have analyzed following parameters: cytological
results of pap smear, pathohistological results of biopsy and pathohistological results of
conus. We divided those three parameters into two groups: LSIL and HSIL. Then we
compared correlation among pathohistological result of biopsy according to pathohistological
result of conus and cytological result of pap smear according to pathohistological result of
biopsy and pathohistological result of conus.
Settings. Case histories were taken from the archive of the Department of Obstetrics
and Gynecology. Pap smear was analyzed at the citological department of the Department of
Pathology, Forensic Medicine and Cytology of Clinical Hospital in Split. Pathohistological
results of biopsy and conus taken by minor surgery were analyzed at the Department of
Pathology, Forensic Medicine and Cytology of Clinical Hospital in Split.
Patients and methods. We wrote about examines who underwent surgery of
conization or LLETZ. Age, parity, cytological pap smear data, pathohistological results of
biopsy, pathohistological results of conus and type of surgery were analyzed. Parameters from
cytological results of pap smear were divided into Low-grade Squamous Intraepithelial
Lesion (LSIL) that enclose CIN I changes and High-grade Squamous Intraepithelial Lesion
(HSIL) that enclose CIN II and CIN III changes. Colposcopy was done preoperatively.
Results. We have analyzed results of 106 testees. Comparison of pap smear results and
pathohistological results of biopsy showed us that there was statistically significant
connection among diagnostical methods (P=0.024). Comparison of pap smear results and
pathohistological results of conization showed us that there was no significant connection
among observed diagnostical methods (P=0.097). Comparison of pathohistological results of
biopsy and patohistologic results of conus showed us that there was statistically significant
connection among observed diagnostical methods (P=0.004).
Conclusion. With the analysis of citological pap smears we conclude that pap smear is
a reliable method in the detection of preneoplastican lesion of cervix. In our pattern we can
also be satisfied with reliability of pap smear. |
Parallel keywords (Croatian) | Displazija vrata maternice Vaginalni razmazi |
Resource type | text |
Access condition | Access restricted to students and staff of home institution |
Terms of use |  |
URN:NBN | https://urn.nsk.hr/urn:nbn:hr:171:430519 |
Committer | Linda Ivas |