Ciljevi: Primarni cilj ovog diplomskog rada je prikazati rezultate desetogodišnjeg liječenja lokalno uznapredovalog raka prostate ART na Klinici za onkologijui radioterapiju KBC Split u razdoblju od 2003. do 2012. godine. Zanimalo nas je BRFS, MRFS i OS. Ispitanici i metode: Retrospektivno smo obuhvatili 75 pacijenata s lokalno uznapredovalim rakom prostate koji su nakon RP imali povećan rizik ostatne bolesti ili povrata bolesti, a liječeni su u razdoblju od 2003. do 2012. godine na Klinici za onkologiju i radioterapiju KBC Split ART konvencionalnom 2D ili 3D CRT medijanom doze od 66 Gy, u medijanu trajanja 1,6 mjeseci. Rezultati: Ovim istraživanjem pokazali smo kako je stopa desetogodišnjeg BRFS 96% jednako kao i OS. MRFS iznosi 100%. Zaključci: Izvrsni rezultati ove studije pokazuju kako je ART lokalno uznapredovalog raka prostate metoda izbora za liječenje ovog stadija bolesti nakon RP. ART smanjuje rizik od biokemijskog i kliničkog povrata bolesti i potencijalno poboljšava ukupno preživljenje oboljelih od raka prostate.

Objectives: The primary objective of this thesis is to demonstrate the results of ten years adjuvant radiotherapy (ART) treatment for locally advanced prostate cancer at the Department of Oncology and Radiotherapy University Hospital Centre Split from 2003 to 2012. We were intrested in Overall Survival (OS), Biochemical Relapse – Free Survival (BRFS) and Metastatic Relapse – Free Survival (MRFS). Patients and Methods: We retrospectively included 75 patients with locally advanced prostate cancer who had an increased risk of residual disease or recurrence after radical prostatectomy and were adjuvant treated with conventional 2D or 3D CRT, median dose of 66 Gy, median duration of 1,6 months, in the period from 2003 to 2012 at the Department of Oncology and Radiotherapy University Hospital Centre Split. Results: In this study we demonstrated that the 10 – year BRFS rate is 96% as well as the OS. MRFS is 100%. Conclusion: Excellent results in this study demonstrated that ART is therapy of choice for locally advanced prostate cancer for this stage of disease after radical prostatectomy. ART reduces the risk of biochemical and clinical relapse and potentially improves overall survival in patients with prostate cancer.