prikaz prve stranice dokumenta Multinucleated giant extravillous trophoblast cells in the decidua of placentas from pregnancies complicated with preeclampsia
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master's thesis
Multinucleated giant extravillous trophoblast cells in the decidua of placentas from pregnancies complicated with preeclampsia
2017. urn:nbn:hr:171:654689
Berkovic, Anna Helene
University of Split
School of Medicine
Pathology

Cite this document

Berkovic, A. H. (2017). Multinucleated giant extravillous trophoblast cells in the decidua of placentas from pregnancies complicated with preeclampsia (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:654689

Berkovic, Anna Helene. "Multinucleated giant extravillous trophoblast cells in the decidua of placentas from pregnancies complicated with preeclampsia." Master's thesis, University of Split, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:171:654689

Berkovic, Anna Helene. "Multinucleated giant extravillous trophoblast cells in the decidua of placentas from pregnancies complicated with preeclampsia." Master's thesis, University of Split, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:171:654689

Berkovic, A. H. (2017). 'Multinucleated giant extravillous trophoblast cells in the decidua of placentas from pregnancies complicated with preeclampsia', Master's thesis, University of Split, School of Medicine, accessed 28 January 2025, https://urn.nsk.hr/urn:nbn:hr:171:654689

Berkovic AH. Multinucleated giant extravillous trophoblast cells in the decidua of placentas from pregnancies complicated with preeclampsia [Master's thesis]. Split: University of Split, School of Medicine; 2017 [cited 2025 January 28] Available at: https://urn.nsk.hr/urn:nbn:hr:171:654689

A. H. Berkovic, "Multinucleated giant extravillous trophoblast cells in the decidua of placentas from pregnancies complicated with preeclampsia", Master's thesis, University of Split, School of Medicine, Split, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:171:654689

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Metadata
TitleMultinucleated giant extravillous trophoblast cells in the decidua of placentas from pregnancies complicated with preeclampsia
Title (croatian)Multinuklearne orijaške stanice ekstraviloznog trofoblasta u decidui posteljica iz trudnoća s preeklampsijom
AuthorAnna Helene Berkovic
MentorSandra Zekić Tomaš (mentor)
Committee memberJoško Božić (predsjednik povjerenstva)
Committee memberJelena Marušić (član povjerenstva)
Committee memberOzren Polašek (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Pathology)
Split
Defense date and country2017-07-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract
Objectives: To compare the number of Multinucleated Giant Cells (MGC) in the decidua basalis of placentas complicated with preeclampsia (PE) and placentas from normal pregnancies. Subject and Method: Fifteen placental samples from pregnancies complicated with PE and the same number of placental samples from normal pregnancies were taken. For each placental sample the number of MGC, extravillous trophoblast (EVTB) and decidual cells (DC) was counted in the decidua basalis. Immunohistochemistry with primary antibody CK7 was used to distinguish EVTB and MGC from DC. The MGC/DC ratio and MGC/EVTB ratio was also determined. Results: MGC number was significantly higher in placentas complicated with PE. Likewise MGC/DC ratio was found to be significantly higher in the studied group. There was no statistically significant difference in EVTB and DC number as well as MGC/EVTB ratio. Conclusion: Increased MGC number in the decidua basalis could be a morphological sign of PE and hypoxic conditions in the placenta.
Abstract (croatian)
Ciljevi: Usporediti broj multinuklearnih orijaških stanica (MOS) u decidui basalis posteljica iz trudnoća s preeklampsijom (PE) i posteljica iz normalnih trudnoća. Materijali i metode: U ispitivanu skupinu je uključeno petnaest uzoraka posteljica iz trudnoća s PE. Isti broj uzoraka posteljica iz normalnih trudnoća je činio kontrolnu skupinu. U svakom uzorku je određen broj MOSa, stanica ekstraviloznog trofoblasta (EVTB) i decidualnih stanica (DS) u decidui basalis. Za razlikovanje stanica EVTB i MOSa od DSa korišteno je imunohistokemijsko bojanje s primarnim protutijelom CK7. Određen je i odnos MOS/DS i MOS/EVTB. Rezultati: Broj MOS je bio značajno veći u ispitivanoj skupini posteljica u odnosu na kontrolnu skupinu. Odnos MOS/DS je također bio značajno veći u ispitivanoj skupini posteljica. Nije bilo statistički značajne razlike u broju stanica EVTB, DS kao i u odnosu MOS/EVTB između dvije skupine. Zaključak: Povišeni broj MOSa u decidui basalis jedan je od morfoloških znakova koji mogu ukazivati da se radi o posteljici trudnoće s PE, to jest o postojanju hipoksičnih uvjeta.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:654689
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-12-04 14:10:04