| Abstract | Objectives: Obstructive sleep apnea (OSA) by its main characteristic of recurrent intermittent hypoxemia is associated with glucose metabolism alterations and insulin resistance, with increased risk for development of diabetes. The aim of the study was to compare parameters of glucose metabolism in non-diabetic OSA patients with respective controls.
Materials and methods: A total of 25 male newly diagnosed OSA patients and 25 matched control subjects underwent an oral glucose tolerance test (OGTT) and blood sampling for determination of parameters of glucose metabolism. Insulin resistance was assessed by the homeostatic model assessment index of insulin resistance (HOMA-IR).
Results: Fasting plasma glucose level (5.2±0.5 vs. 5.0±0.4 mmol/L; P=0.023) and fasting plasma insulin level (106.2±72.6 vs. 61.4±30.0 pmol/L; P=0.006) were significantly higher in OSA group in comparison with control group. There were no significant differences between groups in the postprandial plasma glucose and insulin levels. HOMA-IR was significantly higher in the OSA group in comparison to control group (3.7±2.9 vs. 2.0±1.6; P=0.006). In OSA group more patients had impaired fasting glucose (28% vs. 4%; P=0.020) and insulin resistance (52% vs. 8%; P=0.007) in comparison with the control group. There was no statistically significant difference in the prevalence of impaired glucose tolerance between groups.
Conclusion: In conclusion, this study confirmed the evidence of glucose metabolism disorders in patients with OSA. |
| Abstract (croatian) | Ciljevi: Opstrukcijska apneja tijekom spavanja (OSA) zbog svoje glavne značajke intermitentne hipoksemije povezana je s promjenama metabolizma glukoze i inzulinskom rezistencijom te s povećanim rizikom za razvoj dijabetesa. Cilj ovog istraživanja bio je usporediti parametre metabolizma glukoze u OSA bolesnika koji ne boluju od dijabetesa s odgovarajućim kontrolama.
Materijali i metode: Ukupno 25 muških novodijagnosticiranih OSA bolesnika i 25 kontrolnih ispitanika podvrgnuto je oralnom testu opterećenja glukozom (OGTT) i uzorkovanju krvi za određivanje parametara metabolizma glukoze. Inzulinska rezistencija procijenjena je homeostatskim modelom procjene inzulinske rezistencije (HOMA-IR).
Rezultati: Jutarnje plazmatske koncentracije glukoze (5,2±0,5 vs. 5,0±0,4 mmol/L; P=0,023) i inzulina (106,2±72,6 vs. 61,4±30,0 pmol/L; P=0,006) bile su značajno više u OSA skupini u usporedbi s kontrolnom skupinom. Nije bilo značajnih razlika između skupina u koncentracijama glukoze i inzulina postprandijalno. HOMA-IR bio je značajno veći u OSA skupini u usporedbi s kontrolnom skupinom (3,7±2,9 vs. 2,0±1,6; P=0,006). Skupina pacijenata s OSA-om imala je značajno veću prevalenciju poremećene glukoze natašte (28% vs. 4%; P=0,020) i inzulinske rezistencije (52% vs. 8%; P=0,007) u usporedbi s kontrolnom skupinom. Nije bilo statistički značajne razlike u prevalenciji poremećene tolerancije glukoze između skupina.
Zaključak: Zaključno, ova studija potvrdila je dokaze o poremećajima metabolizma glukoze u bolesnika s OSA-om. |
