Objectives:The aim of this paper is to examine the incidence of microinvasive carcinoma of the uterine cervix FIGO stage IA1 treated in University Hospital of Split from 1.1.2000. to 1.1.2017., to examine the age of the patient at the diagnosis, to examine the incidence of patohistological types, to examine the incidence of lymphovascular invasion, and to examine the treatmet choice. Methods: By retrospective analysis of histories and discharge letters and the protocol of surgeries of all patients with the CC FIGO stage IA1, assessed from the archives of the Department of Gyneacology and Obstetrics and Department of Oncology in Clinical hospital Split, we examined the following: the age of the patients at the diagnosis, pathohistological diagnosis, lymphovascular invasion and treatment choice. Results:In total 67 women were diagnosed with and treated for the CC FIGO stage IA1 at the Deparment of Gynaecology and Obstetrics and Department of Oncology in Clinical hospital Split in period of 17 years. The highest number of diagnosed carcinomas was in year 2011 (n=8), and the lowest in year 2002 (n=1). The greatest incidence of the carcinoma was in age group 41-50 years of age (21 out of 67;31%). The youngest patient was 26 years old and the oldest was 79 years old, median age was 46 years (IQR 36-56). The most common type of carcinoma was squamous cell carcinoma (60 out of 67;90%). Most of the diagnosed carcinomas were negative for lymphovascular invasion (60 out of 67;90%). The most common surgical procedure used was conization (39 out of 73;58%). Conization was the most common surgical option used regardless of pathohistological type and LVI. Conization was the only treatment option used in age group 21-30 years (3 out of 3;100%). Conization was the most common treatment option used in age groups 31-40 years (18 out of 20;90%) and 41-50 years (10 out of 21;48%). The most common treatment option used in age group 51-60 years was hysterectomy (7 out of 9;78%). Age group 61-70 years was equally as often treated with conization (4 out of 8;50%) as it was with hysterectomy (4 out of 8;50%). The most common treatment option in age group 71-80 years of age was hysterectomy (4 out of 6;67%). Conclusions: In the period of 17 years, in total 67 women were diagnosed with and treated for the carcinoma of the uterine cervix FIGO stage IA1 in our hospital. The median age of our patients was 46 years. The most common type of carcinoma was squamous cell carcinoma. Most carcinomas were negative for lymphovascular invasion. The most common treatment option overall and regardless of pathohistological diagnosis and lymphovascular invasion was conization. Women younger than 50 years of age were most commonly treated with conization, while women older than 51 years of age were most commonly treated with hysterectomy.

Ciljevi: Cilj istraživanja je ispitati pojavnost mikroinvazivnog karcinoma vrata maternice FIGO stadija IA1 liječenog u Sveučilišnoj bolnici Split od 1.1.2000. do 1.1.2017. godine, ispitati: dob pacijentica pri dijagnozi, učestalost patohistološke dijagnoze, učestalost limfokapilarne invazije i odabir liječenja. Metode: Retrospektivnom analizom povijesti bolesti i otpusnih pisama i protokola operacija svih pacijentica s karcinomom vrata maternice FIGO stadij IA1, kojima je pristupljeno putem ulaska u arhive Odjela za Ginekologiju i Obstetriciju i Odjela za Onkologiju Sveučilišne bolnice Split, ispitali smo: dob pacijentica pri dijagnozi, patohistološku dijagnozu, limfokapilarnu invaziju i odabir liječenja. Rezultati: Ukupno 67 žena liječeno je od karcinoma vrata maternice FIGO stadija IA1 na Odjelu za Ginekologiju i Obstetriciju i na Odjelu za Onkologiju Sveučilišne bolnice Split u periodu od 17 godina. Najveći broj dijagnosticiranih karcinoma bio je u 2011. godini (n=8), a najmanji u 2002. godini (n=1). Najveća pojavnost karcinoma bila je u dobnoj skupini 41-50 godina (21 od 67;31%). Najmlađa pacijentica imala je 26 godina, a najstarija 79 godina, srednja dob bila je 46 godina (IQR 36-56). Najčešći tip karcinoma bio je karcinom pločastih stanica (60 od 67;90%). Većina dijagnosticiranih karcinoma bila je negativna za limfokapilarnu invaziju (60 od 67;90%). Najčešći kirurški postupak bila je konizacija (39 od 73;58%). Konizacija je bila najčešći kirurški postupak bez obzira na patohistološku dijagnozu i LKI karcinoma. Konizacija je bila jedini kirurški postupak učinjen u dobnoj skupini 21-30 godina (3 od 3;100%). Konizacija je bila najčešći učinjeni kirurški postupak u dobnim skupinama 31-40 godina (18 od 20;90%) i 41-50 godina (10 od 21;48%). Najčešći kirurški postupak učinjen u dobnoj skupini 51-60 godina bila je histerektomija (7 od 9;78%). U dobnoj skupini 61-70 godina, konizacija i histerektomija učinjene su jednako mnogo puta (4 od 8;50%). Najčešća kirurška opcija u dobnoj skupini 71-80 godina bila je histerektomija (4 od 6;67%). Zaključci: U razdoblju od 17 godina, 67 žena je dijagnosticirano i liječeno od karcinoma vrata maternice FIGO stadija IA1 u našoj bolnici. Srednja dob naših pacijentica bila je 46 godina. Najčešći tip karcinoma je karcinom pločastih stanica. Vaćina karcinoma bila je negativna za limfokapilarnu invaziju. Najčešće učinjena operacija, bez obzira na patohistološku dijagnozu i limfokapilarnu invaziju bila je konizacija. Žene mlađe 50 godina najčešće su liječene konizacijom, dok su one starije od 51 godina najčešće liječene histerektomijom.