prikaz prve stranice dokumenta Fas Ligand expression on Extravillous Trophoblast in placentas from pregnancies complicated with HELLP syndrome
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master's thesis
Fas Ligand expression on Extravillous Trophoblast in placentas from pregnancies complicated with HELLP syndrome
2019. urn:nbn:hr:171:136962
Kurtz, Marie
University of Split
School of Medicine
Pathology

Cite this document

Kurtz, M. (2019). Fas Ligand expression on Extravillous Trophoblast in placentas from pregnancies complicated with HELLP syndrome (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:136962

Kurtz, Marie. "Fas Ligand expression on Extravillous Trophoblast in placentas from pregnancies complicated with HELLP syndrome." Master's thesis, University of Split, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:171:136962

Kurtz, Marie. "Fas Ligand expression on Extravillous Trophoblast in placentas from pregnancies complicated with HELLP syndrome." Master's thesis, University of Split, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:171:136962

Kurtz, M. (2019). 'Fas Ligand expression on Extravillous Trophoblast in placentas from pregnancies complicated with HELLP syndrome', Master's thesis, University of Split, School of Medicine, accessed 23 May 2022, https://urn.nsk.hr/urn:nbn:hr:171:136962

Kurtz M. Fas Ligand expression on Extravillous Trophoblast in placentas from pregnancies complicated with HELLP syndrome [Master's thesis]. Split: University of Split, School of Medicine; 2019 [cited 2022 May 23] Available at: https://urn.nsk.hr/urn:nbn:hr:171:136962

M. Kurtz, "Fas Ligand expression on Extravillous Trophoblast in placentas from pregnancies complicated with HELLP syndrome", Master's thesis, University of Split, School of Medicine, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:171:136962

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Metadata
TitleFas Ligand expression on Extravillous Trophoblast in placentas from pregnancies complicated with HELLP syndrome
Title (croatian)Ekspresija Fas liganda na ekstraviloznom trofoblastu u placentama iz trudnoća koje su komplicirane HELLP sindromom
AuthorMarie Kurtz
MentorSandra Zekić Tomaš (mentor)
Committee memberIvana Kuzmić-Prusac (predsjednik povjerenstva)
Committee memberJelena Marušić (član povjerenstva)
Committee memberIvana Pavlinac Dodig (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Pathology)
Split
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract
Objectives: to compare the staining for Fas Ligand receptor on EVTB in placentas with and without HELLP syndrome. Maternal and gestational age, as well as parity, fetal weight and IUGR were also investigated and analyzed for differences. Subject and method: 10 placentae with HELLP syndrome and 10 control placentae were enrolled in the study. Both groups were immunohistochemically stained with antibody to FasL. We used the HSCORE method for assessment of the immunohistochemical staining of FasL in each sample group. Results: We were able to show a statistically significant increase in FasL expression on EVTB and DC in the placentae of patients with HELLP syndrome compared to the control group. No statistically difference in the immunohistochemical expression between EVTB and DC could be found in the HELLP or control group. Conclusion: Our study has shown a higher occurrence of FasL in placentae of pregnancies complicated by HELLP syndrome. Possibly this is causing higher rates of apoptosis and following inflammatory response at the decidual side and thereby leading to the clinical picture of HELLP syndrome. Further investigations with larger sample are required to confirm the results of the presented study.
Abstract (croatian)
Ciljevi: usporediti imunohistokemijski izražaj Fas liganda (FasL) na ekstraviloznom trofoblastu (EVTB) i decidualnim stanicama (DC) u posteljicama kompliciranim HELLP sindromom te rezultate usporediti s posteljicama normalnih trudnoća. Dob majke, gestacijska dob, paritet, porođajna masa te intrauterini zastoj rasta (IUZR) su također analizirani i uspoređeni između istraživanih skupina. Ispitanici i metode: 10 posteljica iz trudnoća kompliciranim HELLP sindromom i jednak broj posteljica urednih trudnoća je uključen u studiju. Semikvantitativna HSCORE metoda je korištena za procjenu FasL imunohistokemijskog izražaja, zasebno za EVTB i DC. Rezultati: imunohistokemijski izražaj FasL je bio statistički značajno veći u EVTB I DC u posteljicama trudnoća kompliciranim HELLP sindromom u usporedbi s kontrolnom skupinom posteljica. Nije bilo statistički značajne razlike u FasL izražaju između EVTB i DC u svakoj ispitivanoj grupi posteljica. Zaključak: veći imunohistokemijski izražaj FasL na EVTB i DC u posteljicama kompliciranim HELLP sindromom mogao bi doprinijeti razvoju kliničkih karakteristika HELLP sindroma. Potrebne su daljnje studije s većim uzorkom posteljica kako bi se rezultati ovog istraživanja potvrdili.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:136962
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-10-16 06:55:53