Objectives: The aim of this study was to assess knowledge and attitudes of medical students and students of dental medicine at the University of Split School of Medicine towards prescribing of drugs. Materials and methods: In this study we assed students' knowledge an attitudes towards prescribing of drugs, using the questionnaire. The questionnaire was fully anonymous and distributed to medical students and students of dental medicine at the University of Split School of Medicine who attended classes from April to May, 2019. The total number of the students who participated in the research was 597. The data were analyzed using Microsoft Office Excel 2016 and JASP 0.9.2.0. Descriptive analysis was performed, and the results are presented in percentages, and median or mean ± standard deviation (SD) for continuous variables. Non-parametric χ 2 test was used to estimate the difference between the groups and the correlation between the variables. Results: A total of 51.1% of students believed that pain was the main cause of drug prescribing in dental practice. 53.9% of medical students and 67.4% of dental students believed that the most commonly prescribed NSAID was ibuprofen. A total of 49.9% of students answered that the most common source of information on prescribing medicines was prescription books. 53.4% of medical students and 58.8% of dental students think that medicines should be prescribed according to their generic name. Conclusion: The research has shown that medical and dental students have similar knowledge of prescribing drugs. Knowledge of prescribing drugs is of utmost importance for good medical and dental practice. Inadequate knowledge results in improper use of common medicines that can lead to a number of negative consequences. Therefore, continuing training on pharmacological therapy as well as on the rational prescribing of medicines during and after the study is essential. It is also necessary to have good guidelines that will allow physicians and doctors of dental medicine to provide quality therapy and avoid the possibility of prescribing errors.