prikaz prve stranice dokumenta Etiology and antibiotic sensitivity of urinary tract infections in elderly patients treated during the year 2018 in Clinic for infectology, University hospital Split
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master's thesis
Etiology and antibiotic sensitivity of urinary tract infections in elderly patients treated during the year 2018 in Clinic for infectology, University hospital Split
2019. urn:nbn:hr:171:862781
Sobesky, Anna Sophia
University of Split
School of Medicine
Infectology

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Sobesky, A. S. (2019). Etiology and antibiotic sensitivity of urinary tract infections in elderly patients treated during the year 2018 in Clinic for infectology, University hospital Split (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:862781

Sobesky, Anna Sophia. "Etiology and antibiotic sensitivity of urinary tract infections in elderly patients treated during the year 2018 in Clinic for infectology, University hospital Split." Master's thesis, University of Split, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:171:862781

Sobesky, Anna Sophia. "Etiology and antibiotic sensitivity of urinary tract infections in elderly patients treated during the year 2018 in Clinic for infectology, University hospital Split." Master's thesis, University of Split, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:171:862781

Sobesky, A. S. (2019). 'Etiology and antibiotic sensitivity of urinary tract infections in elderly patients treated during the year 2018 in Clinic for infectology, University hospital Split', Master's thesis, University of Split, School of Medicine, accessed 19 March 2025, https://urn.nsk.hr/urn:nbn:hr:171:862781

Sobesky AS. Etiology and antibiotic sensitivity of urinary tract infections in elderly patients treated during the year 2018 in Clinic for infectology, University hospital Split [Master's thesis]. Split: University of Split, School of Medicine; 2019 [cited 2025 March 19] Available at: https://urn.nsk.hr/urn:nbn:hr:171:862781

A. S. Sobesky, "Etiology and antibiotic sensitivity of urinary tract infections in elderly patients treated during the year 2018 in Clinic for infectology, University hospital Split", Master's thesis, University of Split, School of Medicine, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:171:862781

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Metadata
TitleEtiology and antibiotic sensitivity of urinary tract infections in elderly patients treated during the year 2018 in Clinic for infectology, University hospital Split
Title (croatian)Etiologija i antibiotska osjetljvost uzročnika infekcija mokraćnog sustava u bolesnika starije životne dobi liječenih tijekom 2018. godine u Klinici za infektologiju KBC-a Split
AuthorAnna Sophia Sobesky
MentorIvo Ivić (mentor)
Committee memberMarija Tonkić (predsjednik povjerenstva)
Committee memberRenata Pecotić (član povjerenstva)
Committee memberDragan Ledina (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Infectology)
Split
Defense date and country2019-07-19, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract
Objectives: To investigate the most common etiology of bacteria causing urinary tract infection (UTI) and their antibiotic sensitivity in older patients aged 65 years or above. Materials and methods: From January 2018 until December 2018, 107 patients aged 65 years and above were treated for urinary tract infections at the Clinic of Infectology of the University Hospital in Split. We included patients with the diagnosis acute cystitis, prostatocystitis, acute cystopyelitis, acute... More pyelonephritis and urosepsis, which were diagnosed on the basis of clinical evaluation and laboratory diagnostics. The study was conducted as an observational retrospective study. Medical data were retrieved by reviewing the history of medical records stored in the archive of the Clinic of Infectology, University Hospital in Split. Results: The largest number of patients (26,2%) were found in the age group 80 years and above. Urosepsis with 37,4% and pyelonephritis actua with 36,4% were the most frequent encountered diagnosis of patients with urinary tract infections treated in the Infectology department in 2018. E.coli (50,5%) was the most common isolated bacteria causing UTIs, in second place was Proteus mirabilis (15%), followed by Pseudomonas aeruginosa (11,2%), Klebsiella pneumonia (9,4%). E.coli resistance to ampicillin was the highest with 51,9%, followed by fluoroquinolones with 27,8%. High sensitivity to carbapenems with no isolated organsim resistant to it and to nitrofurantoin with 94,1% sensitivity was established. Almost all isolated bacteria in our study were showing sensitivity rates of over 80% to carbapenems. Conclusions: The most common isolated pathogen causing urinary tract infection in older patients visiting the Clinic of Infectology in 2018 was E.coli with 50,5%. Sensitivity of E.coli was 100% to carbapenems, 94,1% to nitrofurantoin, and above 75% for amoxicillin-clavulanic acid, all 4 generations of cephalosporins and aminoglycosides. 27,8% resistance rate to fluoroquinolones preclude their use as first line agents for pyelonephritis, until antibiotic sensitivity has not been established. Nitrofurantoin represents an appropriate first-line agent to treat cystitis in our patient sample and carbapenems, 4th generation cephalosporins or amoxicillin-clavulanic acid should be considered as first-line agents for pyelonephritis Less
Abstract (croatian)
Naslov: Etiologija i antibiotska osjetljvost uzročnika infekcija mokraćnog sustava u bolesnika starije životne dobi liječenih tijekom 2018. godine u Klinici za infektologiju Kliničkog bolničkog centra Split. Ciljevi: Istražiti najčešće bakterijske uzroničnike infekcija mokraćnog sustava i njihovu osjetljivost na antibiotike u starih bolesnika životne dobi od 65 i više godina. Materijali i metode: Od siječnja do prosinca 2018.godine na Klinici za infektologiju Kliničkog... More bolničkog centra Split liječeno je 107 bolesnika u dobi od 65 i više godina zbog infekcije mokraćnog sustava (IMS). U istraživanje su uključeni bolesnici s dijagnozom akutnog cistitisa, akutnog pijelonefritisa i urospese. Dijagnoza se temeljila na kliničkoj evaluaciji i laboratorijskog dijagnostici. Istraživanje je provedeno kao opservacijska retrospektivna studija. Medicinski podaci dobiveni su pregledom povijesti bolesti pohranjenih u arhivi Klinike za infektologiju Kliničkog bolničkog centra Split Rezultati: Najveći broj bolesnika (26,2%) bio je dobnoj skupini od 80 i više godina. U 2018. godini zbog IMS liječeno je nešto više ženskih (54,2%) nego muških bolesnika (45,8%) u dobi do 65 i više godina. Urosepsa sa 37,4% i akutni pijelonefritis sa 36,7% bile su najčešće dijagnoze. Najčeše izoliran uzročnik IMS bila je E.coli (50,5%), na drugom mjestu je bio Proteus mirabilis (15%), a potom Pseudomonas aeruginosa (11,2%) i Klebsiella pneumonia (9,4%). E.coli bila je najčešće rezistentna na ampicilin sa 51,9%, a potom na fluorokinolone sa 27,8%. Utvrđena je visoka osjetljivost E.coli na karbapeneme, bez ijednog rezistentnog izolata, te na nitrofurantoin na koji je bilo osjetljivo 94,1% izolata. Gotovo sve druge izolirane bakterije pokazale su osjetljivost na karbapeneme od preko 80%. Zaključci: Sa 50,5% E.coli bila je najčešće izolirani uzročnik IMS u starijih bolesnika koji su 2018. godine liječeni na Klinici za infektologiju. Slijedili su je P.mirabilis sa 15% na drugom i P.aeruginosa sa 11,2% na trećem mjestu. Osjetljivost E.coli na karbapeneme bila je 100%, na nitrofurantoin 94,1%, te preko 75% na amoksicilin-klavulanat, na sve 4 generacije cefalosporina i na aminoglikozide. Rezistenija E.coli na flurokinolone od 27,8% isključuje ih kao antibiotike prvog izbora za pijelonefritis dok se ne utvrdi osjetljivost uzročnika na antibiotike. Srećom nitrofurantoin je odgovarajući lijek prvog izbora za liječenje cistitisa i u naših bolesnika.Pijelonefritis i urosepsa, infekcije koje su bile češće u našoj bolnici, trebalo bi empirijski liječiti amoksicilin-klavulanatom, trećom ili četvrtom generacijom cefalosporina, ili u težoj prezentaciji bolesti karbapenemima kao poduzanim lijekvima prije nego se odredi antibiogram i prema njemu prilagodi terapija. Less
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:862781
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-11-21 14:37:33
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