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master's thesis
IZRAŽAJ SUBPOPULACIJA MONOCITA I NK STANICA U BOLESNIKA S AKUTNIM KORONARNIM SINDROMOM
2020. urn:nbn:hr:171:619158
Kumrić, Marko
University of Split
School of Medicine
Pathophysiology

Cite this document

Kumrić, M. (2020). IZRAŽAJ SUBPOPULACIJA MONOCITA I NK STANICA U BOLESNIKA S AKUTNIM KORONARNIM SINDROMOM (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:619158

Kumrić, Marko. "IZRAŽAJ SUBPOPULACIJA MONOCITA I NK STANICA U BOLESNIKA S AKUTNIM KORONARNIM SINDROMOM." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:619158

Kumrić, Marko. "IZRAŽAJ SUBPOPULACIJA MONOCITA I NK STANICA U BOLESNIKA S AKUTNIM KORONARNIM SINDROMOM." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:619158

Kumrić, M. (2020). 'IZRAŽAJ SUBPOPULACIJA MONOCITA I NK STANICA U BOLESNIKA S AKUTNIM KORONARNIM SINDROMOM', Master's thesis, University of Split, School of Medicine, accessed 29 May 2022, https://urn.nsk.hr/urn:nbn:hr:171:619158

Kumrić M. IZRAŽAJ SUBPOPULACIJA MONOCITA I NK STANICA U BOLESNIKA S AKUTNIM KORONARNIM SINDROMOM [Master's thesis]. Split: University of Split, School of Medicine; 2020 [cited 2022 May 29] Available at: https://urn.nsk.hr/urn:nbn:hr:171:619158

M. Kumrić, "IZRAŽAJ SUBPOPULACIJA MONOCITA I NK STANICA U BOLESNIKA S AKUTNIM KORONARNIM SINDROMOM", Master's thesis, University of Split, School of Medicine, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:171:619158

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Metadata
TitleIZRAŽAJ SUBPOPULACIJA MONOCITA I NK STANICA U BOLESNIKA S AKUTNIM KORONARNIM SINDROMOM
Title (english)EXPRESSION OF MONOCYTE AND NK CELL SUBPOPULATIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME
AuthorMarko Kumrić
MentorTina Tičinović Kurir (mentor)
Committee memberJoško Božić (predsjednik povjerenstva)
Committee memberAnita Markotić (član povjerenstva)
Committee memberJakša Zanchi (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Pathophysiology)
Split
Defense date and country2020, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Svrha istraživanja: Svrha ovog istraživanja bila je utvrditi dinamiku CD226+ NK stanica u bolesnika s akutnim koronarnim sindromom sa ST-elevacijom (engl. STE-ACS) te odrediti razliku u broju CD56- NK stanica i CD14++CD16- monocita u bolesnika sa STE-ACS-om u odnosu na bolesnike s akutnim koronarnim sindromom bez ST-elevacije (engl. NSTE-ACS). Ispitanici i metode: Ovo presječno istraživanje je obuhvatilo 10 bolesnika sa STE-ACS-om i 8 bolesnika s NSTE-ACS-om liječenih u Kliničkom bolničkom centru Split, u razdoblju od veljače do lipnja 2019. kojima su uzeti uzorci krvi pri prijemu, odnosno tada i nakon 3 sata u slučaju bolesnika sa STE-ACS-om. Za analizu subpopulacija NK stanica i monocita korišten je protočni citometar. Rezultati: Nakon 3 sata od prijema u perifernoj krvi dolazi do smanjenja broja CD226+ NK stanica u bolesnika sa STE-ACS-om (P=0,010). Broj CD56- NK stanica u bolesnika sa STE-ACS-om značajno je veći nego u bolesnika s NSTE-ACS-om (P=0,023). U broju CD14++CD16- subpopulacije monocita između skupina sa NSTE-ACS-om i STE-ACS-om nije bilo statistički značajne razlike (P=0,645). Zaključci: Istraživanje je pokazalo očekivanu dinamiku smanjenja broja CD226+ subpopulacije NK stanica, a smatramo da je tomu tako zbog migracije istih u infarcirano područje miokarda. Broj CD56- NK stanica je veći u bolesnika sa STE-ACS-om, a kako do sada nisu provedena slična istraživanja, ne znamo pravo značenje utvrđene razlike. Klasična subpopulacija monocita nije pokazala razliku među skupinama AKS sa i bez ST elevacije, što odgovara podacima iz literature.
Abstract (english)
Objectives: To determine the dynamics of CD226+ NK cells in patients with ST-elevation acute coronary syndrome (STE-ACS) and to compare levels of CD56- NK cells and CD14++CD16- monocytes in patients with STE-ACS in comparison to patients with non ST-elevation acute coronary syndrome (NSTE-ACS). Materials and methods: This cross sectional study consisted of 10 patients with STE-ACS and 8 patients with NSTE-ACS from February to June 2019. hospitalized in the University Hospital of Split. Patients' blood was drawn at admission and, in patients with STE-ACS, after 3 hours too. Method used for NK cells and monocytes counting was flow cytometry. Results: Number of CD226+ NK cells have shown significant decrease on 3 hours after hospital admission in patients with STE-ACS (P=0.010). Furthermore, number of CD56- NK cells was significantly higher in patients with STE-ACS versus in patients with NSTE-ACS (P=0.023). There was no significant difference in CD14++CD16- monocyte numbers between STE-ACS and NSTE-ACS patients (P=0.645). Conclusions: Study has shown expected reduction of CD226 NK cells in peripheral blood, which, we argue, is due to migration in ischemic area of the heart. The CD56- NK cell subpopulation was significantly bigger in the STE-ACS group compared to the NSTE-ACS group but since no similiar research has been conducted yet, the meaning of observed difference still remains unknown. We have shown no difference in number of classical monocyte subpopulation which is in conjuction with available data.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:619158
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-07-24 06:55:01