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master's thesis
Usporedba parametara koštane snage i rizika prijeloma u postmenopauzalnih žena i bolesnica sa šećernom bolesti tipa 2
2020. urn:nbn:hr:171:576867
Kovačević, Barbara
University of Split
School of Medicine

Cite this document

Kovačević, B. (2020). Usporedba parametara koštane snage i rizika prijeloma u postmenopauzalnih žena i bolesnica sa šećernom bolesti tipa 2 (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:576867

Kovačević, Barbara. "Usporedba parametara koštane snage i rizika prijeloma u postmenopauzalnih žena i bolesnica sa šećernom bolesti tipa 2." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:576867

Kovačević, Barbara. "Usporedba parametara koštane snage i rizika prijeloma u postmenopauzalnih žena i bolesnica sa šećernom bolesti tipa 2." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:576867

Kovačević, B. (2020). 'Usporedba parametara koštane snage i rizika prijeloma u postmenopauzalnih žena i bolesnica sa šećernom bolesti tipa 2', Master's thesis, University of Split, School of Medicine, accessed 22 December 2024, https://urn.nsk.hr/urn:nbn:hr:171:576867

Kovačević B. Usporedba parametara koštane snage i rizika prijeloma u postmenopauzalnih žena i bolesnica sa šećernom bolesti tipa 2 [Master's thesis]. Split: University of Split, School of Medicine; 2020 [cited 2024 December 22] Available at: https://urn.nsk.hr/urn:nbn:hr:171:576867

B. Kovačević, "Usporedba parametara koštane snage i rizika prijeloma u postmenopauzalnih žena i bolesnica sa šećernom bolesti tipa 2", Master's thesis, University of Split, School of Medicine, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:171:576867

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Metadata
TitleUsporedba parametara koštane snage i rizika prijeloma u postmenopauzalnih žena i bolesnica sa šećernom bolesti tipa 2
Title (english)Comparison of bone strength parameters and fracture risk in postmenopausal women with type 2 diabetes and healthy postmenopausal women
AuthorBarbara Kovačević
MentorTina Tičinović Kurir (mentor)
Committee memberMladen Krnić (predsjednik povjerenstva)
Committee memberJoško Božić (član povjerenstva)
Committee memberIvana Pavlinac Dodig (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2020, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Cilj istraživanja: Cilj istraživanja bio je ispitati i usporediti parametre koštane snage i rizika za prijelom između postmenopauzalnih žena koje boluju od šećerne bolesti tipa 2 (DM2) i zdravih postmenopauzalnih žena. Materijali i metode: U istraživanje je uključeno ukupno 26 postmenopauzalnih žena. Glavnu skupinu činilo je 12 postmenopauzalnih žena koje boluju od DM2, a kontrolnu skupinu 14 zdravih postmenopauzalnih žena. U istraživanje su uključene žene koje su došle na denzitometrijsko snimanje u Regionalni centar za dijabetes, endokrinologiju i bolesti metabolizma KBC-a Split u razdoblju od 15. siječnja 2019. do 15. ožujka 2020. godine. Ispitanice su ispunile anketni upitnik koji je obuhvatio osobne podatke i podatke potrebne za izračunavanje desetogodišnjeg rizika za prijelom pomoću Alata za procjenu rizika prijeloma (FRAX). Vrijednosti parametara koštane snage uzete su iz medicinske dokumentacije, a rizik za prijelom izračunat je pomoću FRAX-a koristeći podatke iz anketnog upitnika. Rezultati: Nije pronađena statistički značajna razlika u mineralnoj koštanoj gustoći (BMD) kuka, vrata bedrene kosti niti kralježaka L1-L4 između promatranih skupina (P=0,217, P=0,816, P=0,102). Prosječna vrijednost indeksa trabekularne strukture kosti (TBS) u skupini ispitanica s DM2 iznosila je 1,26±0,11 što znači da imaju narušenu mikroarhitekturu kosti, no nije pronađena statistički značajna razlika u usporedbi s kontrolnim ispitanicama (P=0,446). Desetogodišnji rizik za veliki osteoporotični prijelom i prijelom kuka u promatranim skupinama se također nisu statistički razlikovali (P=0,118, P=0,129). Zaključak: Ovo istraživanje je pokazalo da su postmenopauzalne žene s DM2 imale podjednaku mineralnu gustoću kosti i trabekularnu strukturu kosti u odnosu na zdrave, postmenopauzalne žene. Rizik za prijelom u postmenopauzalnih žena s DM2 bio je jednak riziku za prijelom zdravih, postmenopauzalnih žena.
Abstract (english)
Aim: The aim of the study was to examine and compare the parameters of bone strength and fracture risk between postmenopausal women with type 2 diabetes (DM2) and healthy postmenopausal women. Patients and methods: A total of 26 postmenopausal women were included in the study. The main group consisted of 12 postmenopausal women with DM2, and the control group consisted of 14 healthy postmenopausal women. The study included women who came for densitometric imaging at the Regional Center for Diabetes, Endocrinology and Metabolic Diseases of the Clinical Hospital Center Split in the period from January 15, 2019 and March 15, 2020. Respondents completed a questionnaire that included personal data and data needed to calculate a ten-year fracture risk using the Fracture Risk Assessment Tool (FRAX). Values of bone strength parameters were taken from medical records, and fracture risk was calculated using FRAX and data from the survey questionnaire. Results: No statistically significant difference was found in bone mineral density (BMD) of the hip, femoral neck, or lumbar spine between the observed groups (P=0.217, P=0.816, P=0.102). The average value of the trabecular bone score (TBS) in the group of subjects with DM2 was 1.26±0.11, which means that they have impaired bone microarchitecture, but no statistically significant difference was found compared to control subjects (P=0.446). The ten-year risk for major osteoporotic fracture and hip fracture in the observed groups also did not differ statistically (P=0.118, P=0.129). Conclusion: This study showed that postmenopausal women with DM2 had equal bone mineral density and bone trabecular structure compared to healthy, postmenopausal women. The risk of fracture in postmenopausal women with DM2 was equal to the risk of fracture in healthy, postmenopausal women.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:576867
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-07-24 10:41:32