prikaz prve stranice dokumenta Adropin in patients with heart failure
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master's thesis
Adropin in patients with heart failure
2020. urn:nbn:hr:171:882595
Scimeca, Giovanni
University of Split
School of Medicine
Pathophysiology

Cite this document

Scimeca, G. (2020). Adropin in patients with heart failure (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:882595

Scimeca, Giovanni. "Adropin in patients with heart failure." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:882595

Scimeca, Giovanni. "Adropin in patients with heart failure." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:882595

Scimeca, G. (2020). 'Adropin in patients with heart failure', Master's thesis, University of Split, School of Medicine, accessed 19 March 2025, https://urn.nsk.hr/urn:nbn:hr:171:882595

Scimeca G. Adropin in patients with heart failure [Master's thesis]. Split: University of Split, School of Medicine; 2020 [cited 2025 March 19] Available at: https://urn.nsk.hr/urn:nbn:hr:171:882595

G. Scimeca, "Adropin in patients with heart failure", Master's thesis, University of Split, School of Medicine, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:171:882595

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Metadata
TitleAdropin in patients with heart failure
Title (croatian)Adropin u bolesnika sa zatajenjem srca
AuthorGiovanni Scimeca
MentorJoško Božić (mentor)
Committee memberDarko Modun (predsjednik povjerenstva)
Committee memberDuška Glavaš (član povjerenstva)
Committee memberIvana Pavlinac Dodig (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Pathophysiology)
Split
Defense date and country2020-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathophysiology
Abstract
Objectives: The aim of this study is to determine serum adropin levels in patients with heart failure in comparison with healthy controls. Patients and methods: This study enrolled a total of 30 heart failure patients and 30 healthy control subjects. The heart failure patients were evaluated in the first 24 hours of hospital admission. Evaluation included physical examination, medical history, venous blood sampling, blood pressure measurement, and transthoracic echocardiography (TTE).... More American Society of Echocardiography (ASE) guidelines were used for TTE examination. Laboratory analyses of collected venous blood samples was performed at Department of Medical Laboratory Diagnostics by experienced biochemist that was blinded to subject group assignment. Serum adropin levels were determined with dual enzyme-linked immunosorbent assay (ELISA) (Phoenix Pharmaceuticals, Burlingame, USA). Results: Patients with heart failure had significantly higher serum levels of adropin compared to the control group (7.1 ± 0.56 vs 4.23 ± 0.31 ng/mL, P<0.001). We found a positive correlation between serum adropin and NYHA score (r = 0.389, P=0.002), NT-proBNP (r = 0.393, P=0.001) and BMI (r = 0.256, P=0.035). A negative correlation was found between serum adropin and LVEF (r = -0.325, P=0.011) and CRP (r = -0.259, P=0.045). Conclusions: Serum adropin is significantly increased in people with heart failure compared to the control group which implies possible involvement of adropin in heart failure pathophysiology. However, future larger multicentric studies are needed to address these findings. Less
Abstract (croatian)
Ciljevi: Cilj ovog istraživanja je utvrditi razinu adropina u serumu u bolesnika sa zatajenjem srca i usporediti je s razinom adropina u serumu zdravih kontrolnih ispitanika. Metode: Ovo je istraživanje obuhvatilo ukupno 30 bolesnika sa zatajenjem srca i 30 zdravih ispitanika. Bolesnici sa zatajivanjem srca procjenjivani su u prva 24 sata po prijemu u bolnicu. Procjena je uključivala fizikalni pregled, povijest bolesti, uzimanje uzorka venske krvi, mjerenje krvnog tlaka i transtorakalnu... More ekokatiografiju (TTE). Za ispitivanje TTE korištene su smjernice Američkog društva za ehokardiografiju (ASE). Laboratorijske analize uzetih uzoraka venske krvi napravljene su na Odjelu za medicinsku laboratorijsku dijagnostiku od strane iskusnog biokemičara, koji je bio zaslijepljen za skupine ispitanika. Razine adropina u serumu određene su ELISA metodom (Phoenix Pharmaceuticals, Burlingame, SAD). Rezultati: Pacijenti sa zatajivanjem srca imali su značajno više razine adropina u serumu u usporedbi s kontrolnom skupinom (7,1 ± 0,56 naprema 4,23 ± 0,31 ng/mL, P <0,001). Analizom je utvrđena pozitivna povezanost između serumskog adropina i NYHA zbira (r = 0,389, P = 0,002), NT-proBNP-a (r = 0,393, P = 0,001) i BMI-a (r = 0,256, P = 0,035). Pronađena je negativna povezanost između serumskog adropina i LVEF-a (r = -0,325, P = 0,011) i CRP (r = -0,259, P = 0,045). Zaključak: Serumski adropin je značajno povišen u bolesnika sa zatajenjem srca u odnosu na kontrolnu skupinu, što implicira moguću uključenost adropina u patofiziologiju zatajenja srca. Međutim, potrebne su buduća veća multicentrična ispitivanja kako bi se razjasnili ovi nalazi. Less
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:882595
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-09-17 06:53:39
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