prikaz prve stranice dokumenta Comparison of the frequency and intensity of the systemic inflammatory response in patients undergoing cardiac muscle revascularization surgery with and without the use of extracorporeal blood flow
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master's thesis
Comparison of the frequency and intensity of the systemic inflammatory response in patients undergoing cardiac muscle revascularization surgery with and without the use of extracorporeal blood flow
2020. urn:nbn:hr:171:330241
Chacon Arenas, Diego Fernando
University of Split
School of Medicine
Anesthesiology and intensive medicine

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Chacon Arenas, D. F. (2020). Comparison of the frequency and intensity of the systemic inflammatory response in patients undergoing cardiac muscle revascularization surgery with and without the use of extracorporeal blood flow (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:330241

Chacon Arenas, Diego Fernando. "Comparison of the frequency and intensity of the systemic inflammatory response in patients undergoing cardiac muscle revascularization surgery with and without the use of extracorporeal blood flow." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:330241

Chacon Arenas, Diego Fernando. "Comparison of the frequency and intensity of the systemic inflammatory response in patients undergoing cardiac muscle revascularization surgery with and without the use of extracorporeal blood flow." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:330241

Chacon Arenas, D. F. (2020). 'Comparison of the frequency and intensity of the systemic inflammatory response in patients undergoing cardiac muscle revascularization surgery with and without the use of extracorporeal blood flow', Master's thesis, University of Split, School of Medicine, accessed 25 January 2025, https://urn.nsk.hr/urn:nbn:hr:171:330241

Chacon Arenas DF. Comparison of the frequency and intensity of the systemic inflammatory response in patients undergoing cardiac muscle revascularization surgery with and without the use of extracorporeal blood flow [Master's thesis]. Split: University of Split, School of Medicine; 2020 [cited 2025 January 25] Available at: https://urn.nsk.hr/urn:nbn:hr:171:330241

D. F. Chacon Arenas, "Comparison of the frequency and intensity of the systemic inflammatory response in patients undergoing cardiac muscle revascularization surgery with and without the use of extracorporeal blood flow", Master's thesis, University of Split, School of Medicine, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:171:330241

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Metadata
TitleComparison of the frequency and intensity of the systemic inflammatory response in patients undergoing cardiac muscle revascularization surgery with and without the use of extracorporeal blood flow
Title (croatian)Usporedba učestalosti i intenziteta sustavnog upalnog odgovora u bolesnika podvrgnutih revaskularizacijskom zahvatu srčanog mišića sa i bez primjene ekstrakorporalnog krvotoka
AuthorDiego Fernando Chacon Arenas
MentorMihajlo Lojpur (mentor)
Committee memberMladen Carev (predsjednik povjerenstva)
Committee memberBožidar Duplančić (član povjerenstva)
Committee memberZenon Pogorelić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Anesthesiology and intensive medicine)
Split
Defense date and country2020-07-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Abstract
Objectives: The aim of this study was to investigate and compare the degree of the Systemic Inflammatory Response in patients undergoing CABG surgery with and without the use of cardiopulmonary bypass, with an additional focus on investigating the association between inflammatory indicators of SIRS and postoperative hospitalization length, morbidity, and mortality after cardiac surgery. Patients and methods: This study enrolled 30 patients, aged between 52 and 83 years, who were scheduled for elective CABG surgery with or without CPB. Allocation of patients into either group was based on the judgement of the surgical team. Patient leukocyte count, CRP level, PCT level, and number of SIRS criteria were determined before surgery and on the 1st, 2nd, 3rd and 5th postoperative days. Results: Postoperative leukocyte counts were elevated but remained in the ULN. On the contrary, CRP and PCT levels were markedly beyond normal range in the majority of measurements. However, no significant difference in the postoperative leukocyte count, CRP levels, and PCT levels between cardiac surgery with and without CPB was observed. No significant positive correlation was found between higher inflammatory indicators of SIRS and postoperative hospitalization length, morbidity, and mortality. Conclusion: CABG surgery with and without cardiopulmonary bypass are associated with a similar Systemic Inflammatory Response. Hospital stay, morbidity, and mortality after cardiac surgery is the same regardless of the presence of CPB. Our study failed to demostrate any difference in the frequency and intensity of the Systemic Inflammatory Response in patients undergoing cardiac muscle revascularization surgery with and without the use of extracorporeal blood flow.
Abstract (croatian)
Ciljevi: Cilj ove studije bio je istražiti i usporediti stupanj sistemskog upalnog odgovora kod pacijenata koji su podvrgnuti CABG operaciji sa i bez upotrebe kardiopulmonalne zaobilaznice, s dodatnim fokusom na ispitivanje povezanosti između pokazatelja upale SIRS-a i duljine postoperativne hospitalizacije, morbiditeta , i smrtnost nakon srčane operacije. Spitanici i postupci: Ovo je istraživanje obuhvatilo 30 pacijenata, starih između 52 i 83 godine, kojima je bila predviđena izborna operacija CABG-a sa ili bez CPB-a. Raspodjela pacijenata u bilo koju skupinu temeljila se na prosudbi kirurškog tima. Broj leukocita bolesnika, razina CRP-a, razina PCT-a i broj SIRS kriterija određeni su prije operacije i 1., 2., 3. i 5. postoperativni dan. Rezultati: Postoperativni broj leukocita je povišen, ali ostao je u ULN-u. Suprotno tome, u većini mjerenja razina CRP i PCT bila je znatno iznad normalnog raspona. Međutim, nije primijećena značajna razlika u postojperativnom broju leukocita, razini CRP-a i PCT-u između srčane kirurgije sa i bez CPB-a. Nije utvrđena značajna pozitivna povezanost između viših upalnih pokazatelja SIRS-a i duljine postoperativne hospitalizacije, morbiditeta i smrtnosti. Zaključak: Operacija CABG-a sa i bez kardiopulmonalnog bajpasa povezana je sa sličnim sistemskim upalnim odgovorom. Boravak u bolnici, morbiditet i smrtnost nakon kardiološkog zahvata isti su bez obzira na prisutnost CPB-a. Naša studija nije uspjela utvrditi nijednu razliku u učestalosti i intenzitetu sistemskog upalnog odgovora kod pacijenata koji su bili podvrgnuti revaskularizaciji srčanog mišića sa i bez korištenja ekstrakorporalnog protoka krvi.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:330241
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-09-28 10:34:37