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master's thesis
IZRAŽAJ CD44 NA VELIKIM MONOCITIMA NAKON INFARKTA MIOKARDA KOD ŠTAKORA KOJI SU KONZUMIRALI BIJELO VINO
2020. urn:nbn:hr:171:152317
Šimić, Antonela
University of Split
School of Medicine
Department of Basic and Clinical Pharmacology

Cite this document

Šimić, A. (2020). IZRAŽAJ CD44 NA VELIKIM MONOCITIMA NAKON INFARKTA MIOKARDA KOD ŠTAKORA KOJI SU KONZUMIRALI BIJELO VINO (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:152317

Šimić, Antonela. "IZRAŽAJ CD44 NA VELIKIM MONOCITIMA NAKON INFARKTA MIOKARDA KOD ŠTAKORA KOJI SU KONZUMIRALI BIJELO VINO." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:152317

Šimić, Antonela. "IZRAŽAJ CD44 NA VELIKIM MONOCITIMA NAKON INFARKTA MIOKARDA KOD ŠTAKORA KOJI SU KONZUMIRALI BIJELO VINO." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:152317

Šimić, A. (2020). 'IZRAŽAJ CD44 NA VELIKIM MONOCITIMA NAKON INFARKTA MIOKARDA KOD ŠTAKORA KOJI SU KONZUMIRALI BIJELO VINO', Master's thesis, University of Split, School of Medicine, accessed 11 August 2022, https://urn.nsk.hr/urn:nbn:hr:171:152317

Šimić A. IZRAŽAJ CD44 NA VELIKIM MONOCITIMA NAKON INFARKTA MIOKARDA KOD ŠTAKORA KOJI SU KONZUMIRALI BIJELO VINO [Master's thesis]. Split: University of Split, School of Medicine; 2020 [cited 2022 August 11] Available at: https://urn.nsk.hr/urn:nbn:hr:171:152317

A. Šimić, "IZRAŽAJ CD44 NA VELIKIM MONOCITIMA NAKON INFARKTA MIOKARDA KOD ŠTAKORA KOJI SU KONZUMIRALI BIJELO VINO", Master's thesis, University of Split, School of Medicine, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:171:152317

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Metadata
TitleIZRAŽAJ CD44 NA VELIKIM MONOCITIMA NAKON INFARKTA MIOKARDA KOD ŠTAKORA KOJI SU KONZUMIRALI BIJELO VINO
Title (english)EXPRESSION OF CD44 AT LARGE MONOCYTES FOLLOWING MYOCARDIAL INFARCTION IN RATS DRINKING WHITE WINE
AuthorAntonela Šimić
MentorAnita Markotić (mentor)
Committee memberVedrana Čikeš Čulić (predsjednik povjerenstva)
Committee memberTatijana Zemunik (član povjerenstva)
Committee memberAnita Markotić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Department of Basic and Clinical Pharmacology)
Split
Defense date and country2020-10-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Cilj ovoga istraživanja bio je odrediti postotak subpopulacije velikih monocita i izražaj CD44 na velikim monocitima u perifernoj krvi nakon infarkta miokarda štakora koji su 4 tjedna konzumirali bijelo vino ili vodu. Pokusi su izvedeni na mužjacima štakora soja Sprague Dawley koji su randomizacijom podijeljeni u dvije skupine (ispitnu i kontrolnu) s po 9 životinja. Ispitna skupina pila je 28 dana vodu i vino, a kontrolna skupina samo vodu. Nakon 28 dana, životinjama je izazvan infarkt miokarda, a 24 sata nakon je uzorkovana njihova krv. Krv je analizirana metodom protočne citometrije, a rezultati su uspoređeni s rezultatima kontrolne skupine. Konzumacija bijeloga vina nije utjecala na postotak subpopulacije velikih monocita no dovela je do četverostrukoga povećanja izražaja CD44 na njima. CD44 potiče protuupalno djelovanje te također sudjeluje u transformacij fibroblasta u miofibroblaste i zbog toga njegov pojačan izražaj otkriva mogući povoljan utjecaj vina na mehanizme cijeljenja srčanoga tkiva.
Abstract (english)
The aim of this study was to determine the percentage of large monocyte subpopulation and CD44 expression on large monocytes in peripheral blood after myocardial infarction in rats that consumed white wine or water for 4 weeks. The experiments were performed on male Sprague Dawley rats that were randomly divided into two groups of 9 animals each. One group, the test group, drank water and wine for 28 days, and the other group, the control group, drank only water. After 28 days, we induced a myocardial infarction in animals and 24 hours later their blood was sampled. Blood was analyzed by flow cytometry, and the results were compared with the results of the control group. Consumption of white wine did not affect the percentage of subpopulation of large monocytes but led to a fourfold increase in CD44 expression on them. CD44 stimulates anti-inflammatory activity and also participates in the transformation of fibroblasts into myofibroblasts and therefore its enhanced expression reveals the possible beneficial effect of wine on the healing mechanisms of cardiac tissue.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:152317
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-12-14 07:38:46