Objectives: The expression and localization of Creld2 in the nephrons of yotari (Dab1-/-) and wildtype (Dab1+/+) mice was analyzed to further develop its suggested importance in mammal kidneys overall, and its significance particularly in yotari mice nephrons. Materials and methods: Yotari and wildtype mice were sacrificed on the 13.5th embryonal day, and the 4th and 14th postnatal day. Paraffin embedded kidney tissue sections were analyzed by immunofluorescence using Creld2 antibodies. Kidney structures were then examined by fluorescence microscope. The percentages of positive cells in the different nephron structures were compared between yotari and wildtype mice and analyzed by a Kruskal-Wallis test, followed by a t-test. Results: The PCT of postnatal 14D wildtype nephrons showed a strong Creld2 expression signal in the cell cytoplasm and was the structure with the highest percentage of immunoreactive cells (95%) with significantly higher expressions compared to the yotari mice group (P<0.05). The PCTs of postnatal 4D wildtype kidney samples showed significantly higher Creld2 expressions compared to the yotari group (P<0.05). In both mouse groups, the PCTs of 14D postnatal kidneys showed a significantly higher Creld2 expression when compared to the 4D postnatal kidneys (P<0.05). In the E13.5 yotari and wildtype kidney samples, immunoreactive cells were exclusively detectable in the glomeruli, with the wildtype group showing significantly higher Creld2 expressions (P<0.05). The DCTs of both yotari and wildtype kidneys showed mild Creld2 expression with no significant differences found between the mouse groups. Conclusions: Postnatally Creld2 was found to have a possible role in tubular function maintenance especially in the PCT and lesser in the DCT. The appearance of significantly high Creld2 expression in the wildtype glomeruli during the fetal kidney development confirm the potential significant role of Creld2 in the formation of kidney structure. Overall, yotari mice showed lower Creld2 expressions compared to the healthy controls, which might implicate a delayed kidney development in yotari mice.