prikaz prve stranice dokumenta Eosinophils in pathohistological reports of pediatric gastrointestinal biopsies at the University hospital of Split : a three year retrospective study
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master's thesis
Eosinophils in pathohistological reports of pediatric gastrointestinal biopsies at the University hospital of Split : a three year retrospective study
2021. urn:nbn:hr:171:471093
Schnell, Sophie
University of Split
School of Medicine
Pathology

Cite this document

Schnell, S. (2021). Eosinophils in pathohistological reports of pediatric gastrointestinal biopsies at the University hospital of Split : a three year retrospective study (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:471093

Schnell, Sophie. "Eosinophils in pathohistological reports of pediatric gastrointestinal biopsies at the University hospital of Split : a three year retrospective study." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:471093

Schnell, Sophie. "Eosinophils in pathohistological reports of pediatric gastrointestinal biopsies at the University hospital of Split : a three year retrospective study." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:471093

Schnell, S. (2021). 'Eosinophils in pathohistological reports of pediatric gastrointestinal biopsies at the University hospital of Split : a three year retrospective study', Master's thesis, University of Split, School of Medicine, accessed 01 April 2025, https://urn.nsk.hr/urn:nbn:hr:171:471093

Schnell S. Eosinophils in pathohistological reports of pediatric gastrointestinal biopsies at the University hospital of Split : a three year retrospective study [Master's thesis]. Split: University of Split, School of Medicine; 2021 [cited 2025 April 01] Available at: https://urn.nsk.hr/urn:nbn:hr:171:471093

S. Schnell, "Eosinophils in pathohistological reports of pediatric gastrointestinal biopsies at the University hospital of Split : a three year retrospective study", Master's thesis, University of Split, School of Medicine, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:171:471093

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Metadata
TitleEosinophils in pathohistological reports of pediatric gastrointestinal biopsies at the University hospital of Split : a three year retrospective study
Title (croatian)Eozinofili u patohistološkim nalazima pedijatrijskih gastrointestinalnih biopsija u KBC-u Split : trogodišnja retrospektivna studija
AuthorSophie Schnell
MentorSandra Zekić Tomaš (mentor)
Committee memberIvana Mrklić (predsjednik povjerenstva)
Committee memberJoško Markić (član povjerenstva)
Committee memberZenon Pogorelić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Pathology)
Split
Defense date and country2021-07-27, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract
Objectives: With our study we aimed to determine the frequency of an increased number of eosinophils and the most common diseases associated with these findings in gastrointestinal biopsies. We aimed to investigate the most common referral clinical diagnosis for the indication of endoscopy combined with biopsy, the mostly used type of endoscopy, the locations where the biopsies where taken from, which final diagnosis was most commonly represented as well as the average age of the patients. ... More Materials and methods: We conducted a retrospective study with the collected data within the time span from January first 2017 to December 31st 2019 at the department of Pediatrics of the University Hospital of Split, including patients from 0-18 years old, who were examined by gastrointestinal endoscopy combined with biopsy taking. The collection of data included the patient data available in the archives and the pathohistological reports from the biopsies. MedCalc was used for the statistical analysis. Results: From the 336 pathohistological reports 181 (53.9%) were from female patients with a median age at diagnosis of 13 and 155 (46.1%) from male patients with a median age at diagnosis of 12. The most common endoscopic procedure conducted was gastroscopy in 281 cases (83.6%) and in 124 cases (36.6%) biopsies were taken from multiple gastrointestinal locations which was statistically significant (p<0.0001). As well presenting with statistical significance (p<0.0001) malabsorption was the most frequent clinical referral diagnosis with 66 cases (19.6%) and after the pathohistological report the most common final diagnosis was celiac disease (45.5%). In 103 biopsies (32.2%) increased numbers of eosinophils were found and the most common final diagnosis associated with increased eosinophils was again celiac disease with 55 cases (53.4%), both of these findings being statistically significant (p<0.0001). Conclusion: Celiac disease was the most common final diagnosis according to the pathohistological reports as well as the disease most often associated with an increased number of eosinophils. In order to explain the role of eosinophils in various diseases of the gastrointestinal tract further studies are necessary. Less
Abstract (croatian)
Ciljevi: odrediti učestalost povećanog broja eozinofila u patohistološkim nalazima biopsija gastrointestinalnog (GI) trakta, te njihovu povezanost s bolestima GI trakta. Odrediti najučestalije uputne dijagnoze koje su prethodile endoskopiji i posljedičnoj biopsiji. Odrediti najučestalja mjesta GI trakta odakle su uzete biopsije za patohistološku analizu, vrstu endoskopske pretrage, konačnu patohistološku dijagnozu, kao i prosječnu dob bolesnika. Materijali i metode: retrospektivna... More studija je obuhvatila razdoblje od 1. siječnja 2017. godine do 31. prosinca 2019. godine. U studiju su uključeni pacijenti Klinike za dječje bolesti Kliničkog Bolničkog Centra Split kojima je učinjena endoskopska pretraga GI trakta u navedenom razdoblju s uzimanjem biopsije, a patohistološka analiza je učinjena na Odjelu Patologije, Kliničkog Zavoda za Patologiju, Sudsku medicine i Citologiju iste bolnice. Klinički podatci o pacijentima prikupljeni su iz arhive Klinike za dječje bolesti, a patohistološki nalazi iz baze podataka Odjela Patologije. MedCalc je korišten za statističku analizu prikupljenih podataka. Rezultati: Analizirani su podatci 336 bolesnika, 181 (53,9%) bolesnika prosječne dobi od 13 godina te 155 (46,1%) bolesnika prosječne dobi od 12 godina. Najučestalija endoskopska pretraga je bila gastroskopija (83,6%), a u 36,6% slučajeva biopsije su uzete s više različitih lokacija GI trakta u jednom aktu, što je bilo statistički značajno (p<0,0001). Malapsorpcija je najučestalija uputna dijagnoza, koja je zabilježena u 19,6% slučajeva što je bilo statistički značajno (p<0,0001), dok je najučestalija konačna patohistološka dijagnoza bila celijakija, zabilježena u (45,5%). 32,2% svih biopsija je imalo povećan broj eozinofila, a celijakija je najučestalija patohistološka dijagnoza povezana s povećanim brojem eozinofla. Oba navedena rezultata su statistički značajna (p<0,0001) Zaključak: Celijakija je najčešća patohistološka dijagnoza, ujedno i najčešća dijagnoza povezana s povećanim brojem eoznofila u biopsijama GI trakta. Daljnja istraživanja su nužna kako bi se odredila točna uloga eozinofila u različitim bolestima GI trakta. Less
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:471093
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-07-28 08:47:54
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