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master's thesis
Združena primarna radikalna radioterapija i hormonska terapija raka prostate
2014. urn:nbn:hr:171:678293
Martinović, Petra
University of Split
School of Medicine

Cite this document

Martinović, P. (2014). Združena primarna radikalna radioterapija i hormonska terapija raka prostate (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:678293

Martinović, Petra. "Združena primarna radikalna radioterapija i hormonska terapija raka prostate." Master's thesis, University of Split, School of Medicine, 2014. https://urn.nsk.hr/urn:nbn:hr:171:678293

Martinović, Petra. "Združena primarna radikalna radioterapija i hormonska terapija raka prostate." Master's thesis, University of Split, School of Medicine, 2014. https://urn.nsk.hr/urn:nbn:hr:171:678293

Martinović, P. (2014). 'Združena primarna radikalna radioterapija i hormonska terapija raka prostate', Master's thesis, University of Split, School of Medicine, accessed 12 December 2024, https://urn.nsk.hr/urn:nbn:hr:171:678293

Martinović P. Združena primarna radikalna radioterapija i hormonska terapija raka prostate [Master's thesis]. Split: University of Split, School of Medicine; 2014 [cited 2024 December 12] Available at: https://urn.nsk.hr/urn:nbn:hr:171:678293

P. Martinović, "Združena primarna radikalna radioterapija i hormonska terapija raka prostate", Master's thesis, University of Split, School of Medicine, Split, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:171:678293

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Metadata
TitleZdružena primarna radikalna radioterapija i hormonska terapija raka prostate
Title (english)Combined primary radical radiotherapy and hormone therapy for prostate cancer
AuthorPetra Martinović
MentorTomislav Omrčen (mentor)
MBZ: 345720
GranterUniversity of Split
School of Medicine
Split
Defense date and country2014, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract
Ciljevi: Primarni cilj ovog diplomskog rada bilo je istražiti rezultate 10-godišnjeg liječenja (ukupno preživljenje, preživljenje bez biokemijskog povrata bolesti i preživljenje bez udaljenog povrata bolesti) primarnom radikalnom radioterapijom u kombinaciji s hormonskom terapijom kod bolesnika s lokalno uznapredovalim rakom prostate ili rakom prostate srednjeg i visokog rizika liječenih na Klinici za onkologiju i radioterapiju KBC Split u razdoblju od 2003. - 2012. godine. Sekundarni cilj bilo je istražiti kasnu toksičnost kod iste skupine ispitanika. Ispitanici i metode: Provedeno je retrospektivno istraživanje u koje je uključeno 85 bolesnika s lokalno uznapredovalim rakom prostate ili rakom prostate srednjeg i visokog rizika liječenih od 2003. - 2012. g. na Klinici za onkologiju i radioterapiju KBC-a Split. Liječeni su kombiniranom radioterapijom i hormonskom terapijom (goserelin, bikalutamid 150 mg ili goserelin + bikalutamid 50 mg ). Trajanje hormonske terapije ovisilo je o visini rizika za relaps bolesti. Rezultati: Naša studija pokazala je da je stopa petogodišnjeg i sedmogodišnjeg preživljenja bez biokemijskog relapsa bolesti 92,9 % odnosno 90,6 %. Petogodišnje i sedmogodišnje preživljenje bez morfološkog (udaljenog) povrata bolesti je isto i iznosi 92,9 %. Ukupno petogodišnje i sedmogodišnje preživljenje iznosi 85,9 % odnosno 84,7 %. Od ukupnog broja ispitanika 3,5 % ( 3/85 ) ih je prijavilo hemoragijski cistitis, a 10,6 % ( 9/85 ) iradijacijski proktitis. Zaključci: Odlični rezultati ovog istraživanja pokazali su da je dodavanje hormonske terapije radioterapiji indicirano kod bolesnika s lokalno uznapredovalim rakom prostate. Kombinirana hormonska terapija i radioterapija smanjuju rizik od biokemijskog i kliničkog relapsa bolesti te poboljšavaju ukupno preživljenje kod bolesnika s lokalno uznapredovalim rakom prostate i rakom prostate srednjeg i visokog rizika. Dugotrajana hormonska terapija u trajanju od barem 24 mjeseca indicirana je kod bolesnika s visokim rizikom za recidiv, a kratkotrajna hormonska terapija u trajanju od 6 mjeseci kod bolesnika sa srednjim rizikom za recidiv.
Abstract (english)
Objectives: The primary aim of this thesis was to investigate the results of 10-year treatment (Overall Survival, Biochemical Relapse- Free Survival and Metastatic Relapse-Free Survival) with combined primary radical radiotherapy and hormone therapy in patients with locally advanced prostate cancer or intermediate and high risk prostate cancer treated at the Department of Oncology and Radiotherapy, University hospital center Split from 2003 to 2012. Additionaly, we investigated late toxicity of external-beam radiotherapy. Patients and Methods: We conducted retrospective study involving 85 patients with locally advanced prostate cancer or intermediate and high prostate cancer. They were treated with combined primary radical radiotherapy and hormone therapy (goserelin, bicalutamide 150 mg or goserelin + bicalutamide 50 mg). Duration of hormone therapy depended on the amount of risk for relapse. Results: Our study showed that the rate of 5 and 7-year biochemical relapse-free survival is 92,9 % respecitvely 90,6 %. 5 and 7-years metastatic relpase-free survival is the same and amounts 92,9 %. 5 and 7-year overall survivial is 85,9 % respectively 84,7 %. Late toxicity of external-beam radiotherapy was observed in 12 patients. 3 of them had hemorrhagic cystitis and 9 had irradiation proctitis. Conclusion: Combined hormone therapy and radiation therapy reduces the risk of biochemical and clinical relapse of the disease and improves overall survival in patient with locally advanced prostate cancer or intermediate and high risk prostate cancer. Long-term hormone therapy for at least 24 months is indicated in patients at high risk for recurrence, and short-term hormone therapy for a period of 6 months in patients with intermediate risk for recurrence.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:678293
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-03-10 14:17:37