| Abstract | Cilj istraživanja: Cilj istraživanja bio je utvrditi učestalost i klinička obilježja akutne venske tromboembolije (VTE) u bolesnika hospitaliziranih u Kliniku za bolesti srca i krvnih žila MEFST-a i KBC-a Split tijekom prve godine pandemije SARS-CoV-2 virusom. Materijali i metode: Retrospektivna studija za koju su tijekom izrade analizirani podaci medicinske dokumentacije bolesnika hospitaliziranih zbog VTE u Klinici za bolesti srca i krvnih žila MEFST-a i KBC-a Split u razdoblju od 25.2.2020. do 25.2.2021. godine. Rezultati: U prvoj godini pandemije, učestalost hospitalizacije zbog VTE bila je značajno veća u odnosu predpandemijsko razdoblje (P<0,001). Među bolesnicima nije bilo veće razlike po spolu, a glavni rizični čimbenik bila je životna dob. Plućna embolija (PE) bila je najčešća manifestacija VTE (49,35%). Od ukupno 174 bolesnika s PE, 44,25% njih imalo je zahvaćenu glavnu plućnu arteriju, a 10,92% klinički masivnu PE. Skupina bolesnika s klinički masivnom PE imala je statistički značajno veći udio osoba muškog spola (P=0,011) i smrtnih ishoda (P<0,001) u odnosu na skupinu s klinički submasivnom ili nemasivnom PE. 155 bolesnika hospitalizirano je s dijagnozom duboke venske tromboze (DVT), koja je najčešće (56,13%) zahvaćala proksimalne vene nogu. Ukupno je 32 (10,46%) bolesnika imalo pozitivne anamnestičke podatke o preboljeloj COVID-19 bolesti. Među skupinama nije bilo statistički značajne razlike prema dijagnozi (P=0,076), težini kliničke slike PE (P=0,284), nalazima MSCT angiografije plućnih arterija (P =0,260). Također, među skupinama nije bilo statistički značajne razlike u vrijednostima trombocita (P =0,111), D-dimera (P=0,622), PV-a (P=0,132) ni APTV-a (P=0,162). Zaključak: Učestalost hospitalizacije zbog VTE tijekom prve godine pandemije SARS-CoV-2 virusa značajno se povećala u odnosu na predpanedmijsko razdoblje. PE bila je odgovorna za najveći udio hospitalizacija zbog VTE, a u većini slučajeva bile su zahvaćene glavne plućne arterije. U bolesnika s DVT, proksimalne vene nogu bile su najčešće zahvaćene. Nisu pronađene značajne razlike u kliničkim karakteristikama VTE i parametrima koagulacije ovisno o postojanju anamnestičkih podataka o preboljeloj COVID-19. |
| Abstract (english) | Objectives: The aim of the study was to determine the prevalence and clinical characteristics of venous thromboembolism (VTE) in patients hospitalized in the Department of Cardiology of University of Split School of Medicine and University Hospital of Split during the first year of the SARS-CoV-2 pandemic.Materials and methods: This is a retrospective study for which we analyzed data on patients hospitalized in the Department of Cardiology, University Hospital of Split with a diagnosis of VTE in the period from 25.2.2020 to 25.2.2021. Results: In the first year of the pandemic, the prevalence of hospitalization due to VTE was significantly higher than in the pre-pandemic period (P<0.001). Both sexes were similarly affected by VTE, and age was the most common risk factor. Pulmonary embolism (PE) was the most frequent manifestation of VTE (49.35%). 174 patients were diagnosed with PE, of whom 44.25% had main pulmonary artery affected, and 10.92% had clinically massive PE. The group of patients with massive PE had a significantly higher proportion of males (P=0,011) and deaths (P<0,001) compared to the group with clinically submassive or non-massive PE. 155 patients were hospitalized with a diagnosis of deep vein thrombosis (DVT). In the majority of the DVT cases (56.13%) proximal veins of the legs were affected. A total of 32 (10.46%) patients had positive history for COVID-19. Compared with the group of patients who did not have history of COVID-19, there were no significant differences in diagnosis (P=0.076), the severity of PE (P=0.284), findings on MSCT pulmonary angiography (P=0.260). Also, there were no significant differences in platelet counts (P=0.111), D-dimer levels (P=0.622), PT (P=0.132) or APTT (P=0.162) between the groups. Conclusion: The prevalence of VTE hospitalizations during the first year of the SARS-CoV-2 pandemic increased significantly compared to the pre-pandemic period. Both sexes were similarly affected by VTE, and the main predisposing factor for VTE was age. PE was responsible for the largest share of hospitalizations due to VTE and in most of the cases main pulmonary arteries were affected. In patients with DVT, proximal leg veins were the most frequently affected. No significat differences were found in clinical characteristics of VTE and coagulation parametars depending on the existing history of COVID-19. |
