The study was carried out in order to determine the clinical and epidemiological aspects of the ACS in women in the Split-Dalmatia County, hospitalised therewith in the Clinical Hospital Centre Split during the period of two years, 2007 and 2008. Women formed about one third of all persons hospitalised with the ACS during the period in question. Among the women with ACS, four fifths of them were diagnosed with the AIM and every fifth with the UAP, where the NSTEMI was diagnosed in 28.7% of cases, STEMI in 25.2% and UAP in 21.6%, whereas the AIM remained unclassified in one fourth of cases. Women prevailed only in the oldest group of patients and the number of women grew proportionally with age. It was shown that women with the ACS who died were older than those who survived (for STEMI older by 2.39 years, for NSTEMI by 11.72 years and for the unclassified AIM by 5.70 years). Women were significantly older than men (by 6.3 years for those who died and by 7.62 for those who survived). Among all the hospitalised with ACS, more women (11.8%) died than men (6.0%). More men survived than women, and the female sex increased the risk of dying by 2.1 times, whereas with each year of life the risk of dying of the ACS for women increased by 1.07 times. The women hospitalised with the ACS had a delayed arrival to the hospital. Namely, 12.0% of women arrived within 2 hours since the pain had started; 21.7% after 2-6 hours; 16.0% after 6-12 hours; 18.6% after 12-24 hours; and 31.7% after more than 24 hours. Approximately 1/3 of all the recorded complications were diagnosed in the hospitalised women, and there were also more men with the ACS without complications in comparison to women. Among the hospitalised women with complications, there were significantly more of those with heart failure. Hypertension, diabetes mellitus type 1, diabetes mellitus type 2 and unstable angina pectoris were found as risk factors more frequently in women, and active or past smoking in men. In women who were hospitalised and then died of the ACS, hypertension and diabetes mellitus type 2 were found more frequently, and in men active smoking. This study has shown that the non-invasive diagnostic procedures of echocardiography and ergometry were performed more frequently on men than on women. A significant difference in the performance of thrombolysis on men and on women was not determined. The study has determined that the invasive cardiologic procedures (such as coronarography and PCI) were significantly more frequently 57 performed on men than on women. Women with the ACS used the ACE inhibitors significantly more frequently, whereas men more often used the statins in the ACS treatment before hospitalisation. Men received statins at the discharge from the hospital significantly more frequently whereas women were given more ACE inhibitors. This study has established the existence of differences between women and men when it comes to the ACS clinical and epidemiological aspects among citizens of the Split-Dalmatia County, and has mostly confirmed the past results of studies carried out throughout the world. However, the study has also brought new perceptions specific for our region which should be further examined. Attention should be paid to educating all segments of the community and better organisation of the health care.