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Procjena moždane vazoreaktivnosti transkranijskim kolor dopplerom i testom zadržavanja daha u bolesnika nakon preboljele infekcije virusom SARS-COV-2
2022. urn:nbn:hr:171:098006
Marčić, Marino
University of Split
School of Medicine

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Marčić, M. (2022). Procjena moždane vazoreaktivnosti transkranijskim kolor dopplerom i testom zadržavanja daha u bolesnika nakon preboljele infekcije virusom SARS-COV-2 (Doctoral thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:098006

Marčić, Marino. "Procjena moždane vazoreaktivnosti transkranijskim kolor dopplerom i testom zadržavanja daha u bolesnika nakon preboljele infekcije virusom SARS-COV-2." Doctoral thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:098006

Marčić, Marino. "Procjena moždane vazoreaktivnosti transkranijskim kolor dopplerom i testom zadržavanja daha u bolesnika nakon preboljele infekcije virusom SARS-COV-2." Doctoral thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:098006

Marčić, M. (2022). 'Procjena moždane vazoreaktivnosti transkranijskim kolor dopplerom i testom zadržavanja daha u bolesnika nakon preboljele infekcije virusom SARS-COV-2', Doctoral thesis, University of Split, School of Medicine, accessed 25 February 2025, https://urn.nsk.hr/urn:nbn:hr:171:098006

Marčić M. Procjena moždane vazoreaktivnosti transkranijskim kolor dopplerom i testom zadržavanja daha u bolesnika nakon preboljele infekcije virusom SARS-COV-2 [Doctoral thesis]. Split: University of Split, School of Medicine; 2022 [cited 2025 February 25] Available at: https://urn.nsk.hr/urn:nbn:hr:171:098006

M. Marčić, "Procjena moždane vazoreaktivnosti transkranijskim kolor dopplerom i testom zadržavanja daha u bolesnika nakon preboljele infekcije virusom SARS-COV-2", Doctoral thesis, University of Split, School of Medicine, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:171:098006

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Metadata
TitleProcjena moždane vazoreaktivnosti transkranijskim kolor dopplerom i testom zadržavanja daha u bolesnika nakon preboljele infekcije virusom SARS-COV-2
Title (english)Assessment of cerebral vasoreactivity by transcranial color Doppler and breath retention test in patients after SARS-COV-2 virus infection
AuthorMarino Marčić
MentorKatarina Vukojević (mentor)
Committee memberIvica Bilić (predsjednik povjerenstva)
Committee memberRenata Pecotić (član povjerenstva)
Committee memberLiana Cambj Sapunar (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2022, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Uvod: Od početka pandemije virusa SARS-CoV-2 bilo je jasno da je virus izrazito neurotropan. Neurološke manifestacije mogu se kretati od nespecifičnih simptoma kao što su vrtoglavica, glavobolja i smetnje mirisa do teških oblika neurološke disfunkcije. Neke neurološke komplikacije mogu se javiti čak i nakon blagih oblika respiratornih bolesti. Cilj ove studije bio je procijeniti cerebrovaskularnu reaktivnost u bolesnika s nespecifičnim neurološkim simptomima nakon SARS-CoV-2... More infekcije. Metode: Za 25 bolesnika (mušarci N=16, žene N=9), u dobi od 33 do 62 godine, koji su imali nespecifične neurološke simptome 36 dana nakon preboljele blage infekcije SARSCoV-2 virusom i 180 dana nakon početka SARS-COV-2 infekcije, kao i 25 zdravih ispitanika u kontrolnoj skupini, ispitivali smo vazoreaktivnost moždanih krvnih žila pomoću transkranijskog doplera kodiranog bojom i testom zadržavanja daha. Mjerili smo vršnu sistoličku brzinu (PSV, eng. Peak Systolic Velocity), krajnju dijastoličku brzinu (EDV, eng. End-Diastolic Velocity ) i srednju brzinu (MV, eng.Mean flow Velocity), indeks otpora (RI, eng.Resistance Index) i indeks pulsatilnosti (PI, eng.Pulsatility Index) srednje moždane arterije (MCA, eng. Middle Cerebral Artery). Rezultati: 36 dana nakon početka SARS-CoV-2 infekcije pronađene su statistički značajno niže brzine protoka kroz srednju moždanu arteriju u mirovanju [razlika aritmetičkih sredina iznosi za PSV 12,5 (T=4,5, p<0.001), za EDV 4,6 (T=3,2, p=0.002), za MV 9,2 (T=4,4, p<0,001), za RI 0,03 (T=3,1, p=0,003)], niže maksimalne brzine na kraju razdoblja zadržavanja daha (2,4 puta za PSV, za EDV 1,4 puta niže i 1,2 puta niže za MV) i niži indeks zadržavanja daha (BHI) (0,554 vs. p<0,001)) u odnosu na kontrolnu skupinu zdravih ispitanika. Nakon 180 dana od početka SARS-CoV-2 infekcije nema značajnih promjena ispitivanih parametara za PSV (t=1,1, p=0,065), EDV (t=0,21; p=0,837), MV(t=1,6; p=0,118), PI(t=1,1; p=0,286) nakon testa zadržavanja daha ni u fazi mirovanja za PSV (t=1,5; p=0,156), RI (t =1,9; p=0,07), i MV (t=1,4, p=0,066) dok su vrijednosti EDV (t=4,9; p<0,001) i PI (t=2,4; p=0,028) bile više. Zaključci: Smanjenje brzina protoka kroz srednju moždanu arteriju ukazuju na oslabljenu moždanu vazoreaktivnost u skupini ispitanika nakon infekcije SARS-CoV-2 virusom s obzirom na kontrolnu skupinu i sugeriraju oštećenje vaskularnog endotela virusom SARS-CoV-2. Nakon 180 dana od početka infekcije nije došlo do oporavka moždane vazoreaktivnosti kod ispitanika nakon SARS-CoV-2 infekcije. Less
Abstract (english)
Background: From the beginning of the SARS-CoV-2 virus pandemic, it was clear that the virus was highly neurotropic. Neurological manifestations can range from non-specific symptoms such as dizziness, headache and odor disturbances to severe forms of neurological dysfunction. Some neurological complications can occur even after mild forms of respiratory diseases. The aim of this study was to assess cerebrovascular reactivity in patients with nonspecific neurological... More symptoms after SARS-CoV-2 infection. Methods: For 25 patients (men N=16, women N=9), aged 33 to 62 years, who had nonspecific neurological symptoms 36 days after mild SARS-CoV-2 virus infection and 180 days after the onset of SARS-COV-2 infections, as well as 25 healthy subjects in the control group, we examined cerebrovascular vasoreactivity using color-coded transcranial Doppler and breath retention test. We measured peak systolic velocity (PSV), end-diastolic velocity (EDV) and mean velocity (MV), resistance index (RI). ) and the Pulsatility Index (PI) of the Middle Cerebral Artery (MCA). Results: 36 days after the onset of SARS-CoV-2 infection, statistically significantly lower resting cerebral artery flow rates were found [the difference in arithmetic means is for PSV 12.5 (T=4,5, p<0,001), for EDV 4,6 (T=3.2, p=0.002), for MV 9,2 (T=4.4, p <0,001), for RI 0,03 (T=3,1, p=0.003)], lower maximum velocities at the end of the breath holding period (2,4 times) for PSV, for EDV 1,4 times lower and 1,2 times lower for MV) and lower breath retention index (BHI) (0,554 vs. p <0,001)) compared to the control group of healthy subjects 180 days after the onset of SARS -CoV-2 infection there are no significant changes in the examined parameters for PSV (t=1.1, p=0,065), EDV (t=0.21; p=0,837), MV (t=1,6; p=0,118), PI (t=1,1; p=0,286) after the breath hold test and in rest period for PSV (t=1,5; p=0,156), RI (t=1,9; p=0,07), and MV (t=1,4, p=0,066) while the values of EDV (t=4,9; p<0,001) and PI (t =2,4; p=0,028) during rest period were higher. Conclusions: Decreased flow rates through the middle cerebral artery indicate poor cerebral vasoreactivity in the group of subjects after SARS-CoV-2 virus infection relative to the control group and suggest vascular endothelial damage by the SARS-CoV-2 virus. After 180 days from the onset of infection, there was no recovery of cerebral vasoreactivity in subjects after SARS-CoV-2 infection. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:098006
Promotion2022
Study programmeTitle: Evidence-Based Clinical Medicine
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-01-25 08:42:11
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