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doctoral thesis
Novel hybrid PET/MRI applications in neurocognitive disorders
2021. urn:nbn:hr:171:748121
Franceschi, Ana M.
University of Split
School of Medicine

Cite this document

Franceschi, A. M. (2021). Novel hybrid PET/MRI applications in neurocognitive disorders (Doctoral thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:748121

Franceschi, Ana M.. "Novel hybrid PET/MRI applications in neurocognitive disorders." Doctoral thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:748121

Franceschi, Ana M.. "Novel hybrid PET/MRI applications in neurocognitive disorders." Doctoral thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:748121

Franceschi, A. M. (2021). 'Novel hybrid PET/MRI applications in neurocognitive disorders', Doctoral thesis, University of Split, School of Medicine, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:171:748121

Franceschi AM. Novel hybrid PET/MRI applications in neurocognitive disorders [Doctoral thesis]. Split: University of Split, School of Medicine; 2021 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:171:748121

A. M. Franceschi, "Novel hybrid PET/MRI applications in neurocognitive disorders", Doctoral thesis, University of Split, School of Medicine, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:171:748121

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Metadata
TitleNovel hybrid PET/MRI applications in neurocognitive disorders
Title (croatian)Nove primjene hibridne PET/MR metode u neurokognitivnim poremećajima
AuthorAna M. Franceschi https://orcid.org/0000-0003-2577-9738
MentorBoris Brkljačić (mentor)
Committee memberLiana Cambj Sapunar (predsjednik povjerenstva)
Committee memberTonći Batinić (član povjerenstva)
Committee memberMaja Marinović Guić (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2021-12-02, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Radiology
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Introduction: Hybrid brain PET/MRI is a novel imaging modality which offers great advantages over PET/CT in the evaluation of neurocognitive disorders. Specifically, the structural MRI component offers superior soft tissue contrast, lack of radiation exposure, and more information regarding intrinsic tissue characteristics when compared to CT, therefore improving anatomic localization and increasing diagnostic accuracy. Methods: We performed three retrospective studies to analyze: a) added value of including entire brain on FDG PET/MRI body imaging; b) brain FDG PET/MRI for visual detection of crossed cerebellar diaschisis in dementia patients; and c) an optimized, minimal specific absorption rate MRI for high-resolution imaging in parkinsonian patients with implanted deep brain stimulation electrodes. Results: Of the 269 FDG PET/MRI whole-body studies, 37 patients (13.8%) had positive brain pathology, with 39 total intracranial findings identified. Of 75 dementia PET/MRIs, 10 subjects had crossed cerebellar diaschisis; of these 6 with frontotemporal dementia, 3 with corticobasal degeneration and 1 Alzheimer’s disease. For 29 parkinsonism patients with DBS, average SAR deposition for MPRAGE was 0.109±0.021, with no adverse effects during or after imaging. Conclusions: Our study results highlight the potential of hybrid PET/MRI in advanced clinical neuroimaging, with a special emphasis on patients with neurocognitive disorders.
Abstract (croatian)
Uvod: Hibridni PET/MR je nova slikovna metoda koja nudi značajnu prednost u odnosu na PET/CT u evaluaciji neurokognitivnih poremećaja. Posebice, strukturalna MR komponenta nudi izvrsnu kontrastnost mekotkivnih struktura, izostanak izlaganja ionizirajućem zračenju te više informacija vezano za intrinzična svojstva tkiva u usporedbi s CT-om, poboljšavajući anatomsku lokalizaciju i povećavajući dijagnostičku preciznost. Metode: Proveli smo tri retrospektivne studije analizirajući: a) dodatnu vrijednost uključivanja čitavog mozga prigodom snimanja FDG PET/MR tijela; b) FDG PET/MR mozga za vizualnu detekciju križane cerebelarne diashize u bolesnika s demencijom te c) optimizirani minimalni specifični udio apsorpcije (specific absorption rate, SAR) MR kod visoko-rezolucijskih snimanja pacijenata s Parkinsonovom bolešću koji imaju ugrađene elektrode za duboku stimulaciju mozga (DSM). Rezultati: Od 269 bolesnika uključenih u analizu FDG PET/MR cijelog tijela, 37 bolesnika (13,8%) je imalo patološke promjene mozga, dok je ukupno 39 bolesnika imalo intrakranijalnu patologiju. Od 75 bolesnika s demencijom podvrgnutih PET/MR, 10 osoba je imalo križanu cerebelarnu diashizu, od kojih je 6 imalo frontotemporalnu demenciju, 3 kortikobazalnu degeneraciju i jedna osoba Alzheimerovu bolest. Za 29 osoba oboljelih od Parkinsonove bolesti s DSM, prosječan SAR depozit na MPRAGE iznosio je 0.109±0.021, bez nuspojava tijekom ili nakon snimanja. Zaključak: Rezultati naših istraživanja ukazuju na izuzetne mogućnosti hibridnih PET/MR metoda u naprednim kliničkim neurooslikavanjima, osobito u bolesnika s neurokognitivnim poremećajima.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:748121
Promotion2022
Study programmeTitle: Obtaining a doctorate of science outside of doctoral studies
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti (doktor/doktorica znanosti)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-01-25 10:18:51