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master's thesis
Obilježja dojenčadi liječene zbog akutne infekcije donjih dišnih puteva u Klinici za dječje bolesti KBC-a Split u pre-COVID i COVID razdoblju
2022. urn:nbn:hr:171:158056
Mrčela, Dina
University of Split
School of Medicine

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Mrčela, D. (2022). Obilježja dojenčadi liječene zbog akutne infekcije donjih dišnih puteva u Klinici za dječje bolesti KBC-a Split u pre-COVID i COVID razdoblju (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:158056

Mrčela, Dina. "Obilježja dojenčadi liječene zbog akutne infekcije donjih dišnih puteva u Klinici za dječje bolesti KBC-a Split u pre-COVID i COVID razdoblju." Master's thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:158056

Mrčela, Dina. "Obilježja dojenčadi liječene zbog akutne infekcije donjih dišnih puteva u Klinici za dječje bolesti KBC-a Split u pre-COVID i COVID razdoblju." Master's thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:158056

Mrčela, D. (2022). 'Obilježja dojenčadi liječene zbog akutne infekcije donjih dišnih puteva u Klinici za dječje bolesti KBC-a Split u pre-COVID i COVID razdoblju', Master's thesis, University of Split, School of Medicine, accessed 01 April 2025, https://urn.nsk.hr/urn:nbn:hr:171:158056

Mrčela D. Obilježja dojenčadi liječene zbog akutne infekcije donjih dišnih puteva u Klinici za dječje bolesti KBC-a Split u pre-COVID i COVID razdoblju [Master's thesis]. Split: University of Split, School of Medicine; 2022 [cited 2025 April 01] Available at: https://urn.nsk.hr/urn:nbn:hr:171:158056

D. Mrčela, "Obilježja dojenčadi liječene zbog akutne infekcije donjih dišnih puteva u Klinici za dječje bolesti KBC-a Split u pre-COVID i COVID razdoblju", Master's thesis, University of Split, School of Medicine, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:171:158056

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Metadata
TitleObilježja dojenčadi liječene zbog akutne infekcije donjih dišnih puteva u Klinici za dječje bolesti KBC-a Split u pre-COVID i COVID razdoblju
Title (english)Characteristic of infants hospitalized because of acute lower respiratory infections in the Department of Pediatrics, University Hospital of Split before and during Covid pandemic
AuthorDina Mrčela
MentorJoško Markić (mentor)
Committee memberMarija Tonkić (predsjednik povjerenstva)
Committee memberIvana Unić (član povjerenstva)
Committee memberIvana Pavlinac Dodig (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2022, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract
Cilj istraživanja: Cilj ovog istraživanja bio je prikazati karakteristike dojenčadi oboljele od akutne infekcije dišnog sustava (ALRI) u razdoblju prije i tijekom COVID pandemije. Materijali i metode: Provedeno je retrospektivno istraživanje u kojem je uključena sva dojenčad liječena u Klinici za dječje bolesti KBC-a Split u razdoblju od 1. siječnja 2018. do 31. prosinca 2021. pod dijagnozom ALRI. Prikazali smo ukupan broj oboljelih, broj RSV testiranih, broj RSV pozitivnih, težinu... More kliničke slike, epidemiološku sliku pojavnosti ALRI i RSV-a, demografske karakteristike, način prehrane dojenčadi, korištenje antibiotske terapije i duljinu trajanja hospitalizacije. Rezultati: U istraživanje je uključeno 669 pacijenta od kojih je 364 (54,4%) hospitalizirano prije, a 305 (45,6%) tijekom COVID pandemije. Između promatranih razdoblja utvrdili smo statistički značajnu razliku u dobnim skupina oboljelih (P<0,001). Tijekom pandemije broj RSV testirane dojenčadi iznosio je 277 (90,8%), a u pre-COVID periodu 271 (74,4%). Broj RSV pozitivne djece iznosio je 136 (50,2%) za prijepandemijski i 126 (45,5%) za pandemijski period. Između navedenih razdoblja pronađena je statistički značajna razlika u broju RSV testirane (P<0,001), ali ne i RSV pozitivne dojenčadi (P=0,240). U oba razdoblja najveći broj djece prezentirao se kliničkom slikom blage infekcije, no tijekom pandemije zabilježili smo porast broja hospitaliziranih zbog ozbiljne i vrlo ozbiljne infekcije. Analizom je utvrđena statistički značajna razlika u težini kliničke slike oboljele dojenčadi (P=0,014). Također, pandemija SARS–CoV–2 i stroge epidemiološke mjere dovele su do pada inicidencije ALRI kao i promjene sezonalnosti RSV-a. Razdiobom po spolu utvrđena je veća stopa hospitalizacije muške dojenčadi, njih 217 (59,6%) u pre-COVID i 172 (56,4%) u COVID periodu. Prosječna duljina trajanja hospitalizacije iznosila je 5,99 ± 3,6 dana u prijepandemijskom, a 6,97 ± 4,19 u pandemijskom razdoblju. Pronađena je statistički značajna razlika u duljini trajanja hospitalizacije oboljele dojenčadi (P<0,001). Zaključak: Provođenje strogih epidemioloških mjera i razdoblje zatvaranja utjecalo je na promjenu sezonalnosti RSV kao jednog od najčešćeg uzročnika ALRI u djece. U našem istraživanju zabilježen je pad broja hospitaliziranih, kašnjenje sezone RSV-a te pojava RSV pozitivne dojenčadi u razdoblju ljetnih i ranih jesenskih mjeseci. Također, klinička slika oboljele dojenčadi u razdoblju pandemije bila je teža što se očitovalo i na dulje trajanje hospitalizacije. Less
Abstract (english)
Objectives: The aim of this study was to present demographic and clinical characteristics of infants hospitalized because of ALRI before and during COVID pandemic. Subjects and methods: A retrospective study was conducted in which we included hospitalized infants with diagnosis of ALRI treated in Department of Pediatrics, University Hospital of Split in period from January 1st 2018 to December 31st 2021. We analyzed: total number of ALRI, number of RSV tested and RSV positive,... More severity of infection, epidemiological picture of all ALRI and RSV, demographic characteristics (sex, GA, birth weight and hight, number of preterm infants by GA, age, weight and hight in time of hospitalization), diet, antibiotics used in treatment and lenght of hospitalization. Results: The study included 669 patients, out of whom 364 (54.4%) were hospitalized during pre-pandemic and 305 (45.6%) during pandemic period. We found statistically significant difference between age groups among hospitalized with these two periods (P<0.001). The number of RSV tested infants was 277 (90.8%) during pandemic and 271 (74.4%) in pre- COVID period. The number of RSV positive was 136 (50.3%) in pre-pandemic and 126 (45.6%) in pandemic period. A statistically significant difference was found in total number RSV tested (P<0.001) but not RSV positive (P=0.240). In both periods, most children had mild infection, but during pandemic there was increase in number of infants with diagnose severe or very severe illness. A statistically significant difference was found in severity of infection (P=0.014). Also, pandemic of SARS–CoV–2 and epidemiological measures led to a decline in incidence of ALRI as well as changes in the seasonality of RSV. The length of hospitalization before pandemic was 5.99 ± 3.60 and during pandemic 6.97 ± 4.19 days. A statistically significant difference in length of hospitalization between these two period was found (P<0.001). Conclusion: Implementation of strict epidemiological measures and lockdown changed the seasonality of RSV as one of the most common causes of ALRI in children. In our research there was decrease in number of hospitalized, delayed RSV season and the occurrence of RSV positive infants in summer and early autumn months. Also during pandemic there was higher number of infants with clinical presentation of severe and very severe infection which is in correlation with longer duration of hospitalization. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:158056
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-07-08 12:08:30
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