Objectives: The aim of this study was to determine the length of survival without disease recurrence in relation to the type of surgical procedure and histologic type of lung cancer, to analyze the impact of surgical approach on number of extirpated lymph nodes, to analyze the impact of number of extracted and positive lymph nodes on the mediastinal metastases occurence. Subjects and Methods: From December 2012 until September 2017, 70 patients (45 males, 25 females) who underwent surgery for the treatment of non-small-cell lung cancer at the Department of Surgery, University Hospital of Split, were included in the retrospective study. Patients were divided according to the type of surgical approach, histologic type of lung cancer, location of metastases and number of affected and isolated lymph nodes. Results: Between 2012 and 2017, 70 patients were treated surgically for non-small-cell lung cancer either by VATS or open thoracotomy approach. The median age of patients was 65 years. The most frequently diagnosed histologic type was adenocarcinoma (n=47). Lungs were the most common site for metastatic spread. When analyzing the impact of surgical approach on number of affected and isolated lymph nodes there was no statistical difference (P=0.237), (P=0.194). There was no difference between number of affected and isolated lymph nodes with location of metastases (P=0.645, P=0.895). Disease free survival was 17 months shorter in patients with metastases in mediastinum than in patients with metastases in the lungs and 12 months shorter than in patients with metastases in other locations. There was no significant difference of disease free survival between genders (P=0.610), histologic types (P=0.688), age groups (P=0.838), type of surgical approach (P=0.527) and number of affected (P=0.643) and isolated (P=0.499) lymph nodes. Conclusion: Type of surgical approach does not have an impact on number of removed lymph nodes and disease free survival.