| Abstract | Ciljevi: Glavni cilj je bio istražiti povezanost između razina 25-hidroksi vitamina D i stupnja
metaboličkog urušaja u novootkrivenih bolesnika s ŠBT1.
Ispitanici i postupci: U istraživanje je uključeno 83 djece sa novodijagnosticiranom ŠBT1 koja
su primljena na Kliniku za pedijatriju, Zavod za endokrinologiju Kliničkog bolničkog centra
Split (KBC Split) u razdoblju od 1. siječnja 2018. do 31. prosinca 2020. godine. Analiza je
uključivala anamnezu, klinički pregled, antropometrijska mjerenja i uzorkovanje krvi.
Rezultati: Utvrđena je statistički značajno niža vrijednost pH (7,42 – 7,05 vs. 7,42 – 7,33;
P=0,003) te bikarbonata (22,2 – 3,6 mmol/L vs. 23,5 – 13,3 mmol/L; P=0,002) kod skupine sa
koncentracijom 25-hidroksi vitaminom D manjom od 50 nmol/L od skupine sa koncentracijom
vitamina D većom od 50 nmol/L te statistički značajna pozitivna korelacija razine pH (r=0,366;
P=0,001) kao i koncentracije bikarbonata (r=0,340; P=0,002) sa razinom 25-hidroksi vitamina
D. Uz to je utvrđena i statistički značajna negativna korelacija koncentracije ß- hidroksibutirata
sa koncentracijom 25-hidroksi vitamina D (r=-0,246; P=0,030).
Zaključak: Potvrđena je povezanost između razina 25-hidroksi vitamina D i laboratorijskih
parametara pH vrijednosti, bikarbonata i ß- hidrksibutirat koji mogu ukazivati na stupanj
metaboličkog urušaja u novootkrivenih bolesnika sa ŠBT1. |
| Abstract (english) | Objectives: The aim of this study was to establish the association between the levels of 25-
hydroxyvitamin D and the degree of metabolic collapse in newly diagnosed patients with type
1 diabetes mellitus (T1DM).
Subjects and methods: This study enrolled 83 newly T1DM pediatric patients which were
admitted to the Division of Pediatric Endocrinology at the University Hospital of Split in the
period from January 2018 to December 2020. Evaluation included physical examination,
medical history, anthropometric measurement and blood sample.
Results: A statistically significantly lower value of pH (7.42 – 7.05 vs. 7.42 – 7.33; P=0.003)
and bicarbonate (22.2 – 3.6 mmol/L vs. 23.5 – 13, 3 mmol/L; P=0.002) were found in the group
with the concentration of 25-hydroxyvitamin D lower than 50 nmol/L than the group with the
concentration of vitamin D higher than 50 nmol/L. In addition, a statistically significant positive
correlation was found between the pH level (r=0.366; P= 0.001) as well as the concentration
of bicarbonate (r=0.340; P=0.002) and the level of 25-hydroxyvitamin D and a statistically
significant negative correlation between the concentration of ß-hydroxybutyrate and the
concentration of 25-hydroxyvitamin D (r=-0.246; P =0.030).
Conclusion: This study has confirmed the association between the levels of 25-hydroxyvitamin
D and the laboratory parameters of pH value, bicarbonate and ß-hydroxybutyrate, which may
indicate the degree of metabolic collapse in newly diagnosed patients with T1DM. |
