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master's thesis
Učestalost gastroshize i omfalokele u novorođenčadi liječene u Zavodu za intezivnu pedijatriju KBC-a Split u razdoblju od 2002. do 2021. godine
2022. urn:nbn:hr:171:512846
Seleš, Lucija
University of Split
School of Medicine

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Seleš, L. (2022). Učestalost gastroshize i omfalokele u novorođenčadi liječene u Zavodu za intezivnu pedijatriju KBC-a Split u razdoblju od 2002. do 2021. godine (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:512846

Seleš, Lucija. "Učestalost gastroshize i omfalokele u novorođenčadi liječene u Zavodu za intezivnu pedijatriju KBC-a Split u razdoblju od 2002. do 2021. godine." Master's thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:512846

Seleš, Lucija. "Učestalost gastroshize i omfalokele u novorođenčadi liječene u Zavodu za intezivnu pedijatriju KBC-a Split u razdoblju od 2002. do 2021. godine." Master's thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:512846

Seleš, L. (2022). 'Učestalost gastroshize i omfalokele u novorođenčadi liječene u Zavodu za intezivnu pedijatriju KBC-a Split u razdoblju od 2002. do 2021. godine', Master's thesis, University of Split, School of Medicine, accessed 20 April 2024, https://urn.nsk.hr/urn:nbn:hr:171:512846

Seleš L. Učestalost gastroshize i omfalokele u novorođenčadi liječene u Zavodu za intezivnu pedijatriju KBC-a Split u razdoblju od 2002. do 2021. godine [Master's thesis]. Split: University of Split, School of Medicine; 2022 [cited 2024 April 20] Available at: https://urn.nsk.hr/urn:nbn:hr:171:512846

L. Seleš, "Učestalost gastroshize i omfalokele u novorođenčadi liječene u Zavodu za intezivnu pedijatriju KBC-a Split u razdoblju od 2002. do 2021. godine", Master's thesis, University of Split, School of Medicine, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:171:512846

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Metadata
TitleUčestalost gastroshize i omfalokele u novorođenčadi liječene u Zavodu za intezivnu pedijatriju KBC-a Split u razdoblju od 2002. do 2021. godine
Title (english)Frequency of gastroschisis and omphalocele in newborns treated in the Pediatric Intensive Care Unit, Pediatric Clinics, University Hospital of Split, in the period from 2002 to 2021
AuthorLucija Seleš
MentorBranka Polić (mentor)
Committee memberZenon Pogorelić (predsjednik povjerenstva)
Committee memberJoško Markić (član povjerenstva)
Committee memberBernarda Lozić (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2022, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract
Cilj istraživanja: Cilj ovog istraživanja je ispitati pojavnost gastroshize i omfalokele u djece liječene u Zavodu za intenzivnu pedijatriju s postintenzivnom skrbi Klinike za dječje bolesti KBC-a Split, u razdoblju od 2002. do 2021. godine, te analizirati demografske, antropometrijske i kliničke karakteristike te ishode liječenja. Ujedno smo analizirali utjecaj rodne mase, gestacijske dobi i Apgar zbroja na nastanak komplikacija u naših ispitanika. Ispitanici i metode: Istraživanje je obuhvatilo 28 novorođenčadi s gastroshizom i omfalokelom liječene u Zavodu za intenzivnu pedijatriju s postintenzivnom skrbi Klinike za dječje bolesti KBC-a Split u razdoblju od 2002. do 2021. godine. Podaci potrebni za istraživanje su prikupljeni iz bolničke medicinske dokumentacije. Rezultati: Od ukupno 28 novorođenčadi s gastroshizom i omfalokelom 23 (82%) je imalo gastroshizu i 5 (18%) omfalokelu. Carskim rezom je porođeno 92% djece. Među njima je bilo 19 (68%) dječaka i 6 (32%) djevojčica. Medijan rodne mase bio je 2490 g (Q1 - Q3 1990-3027 g; min – maks 770-3490 g). Medijan gestacijske dobi bio je 36,5 tjedana (Q1 - Q3 35,3 - 38 tjedana; min – maks 25 - 41 tjedana). Medijan Apgar zbroja u 1. minuti bio je 8 (Q1 - Q3 6 -8,5; min - maks 1-10) i 8 (Q1 – Q3 7 - 8,5; min – maks 4-10) u 5. minuti. Najčešća perinatalna dijagnoza bila je mekonijska plodova voda, u 11 (42%) novorođenčadi. Kirurški je zbrinuto 27 (96%) djece, jedno dijete je umrlo prije kirurškog zbrinjavanja. Od njih je 19 (70%) zbrinuto primarnim kirurškim zahvatom, a 8 (30%) odgođenim. Najčešća metoda odgođenog zbrinjavanja je bila postavljanje vrećice. Sva djeca, koja su primarno kirurški zatvorena, zbrinuta su u 1. danu života. Medijan dana do definitivnog kirurškog zbrinjavanja u skupini odgođenog zatvaranja iznosio je 9,5 dana (min - maks 3 - 60 dana). Komplikacije je razvilo 22 (79%) djece, a najčešća postoperativna komplikacija bila je sepsa. Pridružene anomalije su bile prisutne u 16 (57%) ispitanika. Sva djeca s omfalokelom i polovina djece s gastroshizom su imala pridružene anomalije. Anomalije srca i krvnih žila su bile najčešće, imalo ih je 13 (46%) djece. Samo je jedno dijete imalo trisomiju 13. Od ukupno 28 novorođenčadi 25 (89%) je preživjelo, a 3 (11%) djece je umrlo zbog kardiopulmonalnog zatajenja. Zaključci: Pravovremeno postavljane dijagnoze ovih anomalija od velike je važnosti za planiranje postnatalne skrbi i okupljanje multidisciplinarnog tima. Napretkom prijeoperacijske skrbi, kirurških tehnika i poslijeoperacijskog zbrinjavanja smanjuje se udio komplikacija i poboljšava se preživljenje. Potrebno je provesti istraživanja koja obuhvaćaju širu populaciju ili prate duže vremensko razdoblje kako bi se donijeli precizniji zaključci.
Abstract (english)
Objectives: The aim of this study was to examine the occurrence of gastroschisis and omphalocele in newborns treated in the Pediatric Intensive Care Unit in the period from 2002. to 2021. and to analyze the demographic, anthropometric and clinical characteristics and outcomes of treatment. We also analyzed the influence of birth weight, gestational age and Apgar score on the occurrence of complications in our subjects. Materials and methods: The study included 28 newborns with gastroschisis and omphalocele who were treated in the PICU, University Hospital of Split in the period from 2002. to 2021. Required information was obtained from hospital medical records. Results: Out of 28 newborns with gastroschisis and omphalocele 23 (83%) had gastroschisis and 5 (18%) had omphalocele. Caesarean section was used to deliver 92% of children. Among them 19 (68%) were male and 6 (32%) were female. The median birth weight was 2490 g (Q1 - Q3 1990-3027 g; min – max 770-3490 g). The median gestational age was 36,5 weeks (Q1 - Q3 35.3 - 38 weeks; min – max 25 - 41 weeks). The median for Apgar score was 8 (Q1 - Q3 6 -8.5; min - max 1-10) in first minute and 8 (Q1 – Q3 7 – 8.5; min – max 4-10) in fifth minute. The most common perinatal diagnosis, meconium-stained amniotic fluid, appeared in 11 (42%) of children. One child died before the surgical care, other 27 (96%) of children had surgery. Of them 19 (70%) were with primary closed and 8 (30%) had delayed closure. Most used method of staged reduction was silo bag. All the primarily closed children were taken care of within 1st day of life. The median of days until definitive surgical care for group of delayed closure was 9.5 days (min - max 3 - 60 days). Complications developed in 22 (79%) of children. Most common complication was sepsis. Associated anomalies were present in 16 (57%) of children. All children with omphalocele and half of the children with gastroschisis had associated anomalies. Cardiovascular anomalies were the most common, with 13 (46%) children having them. Only one child had a trisomy 13. Out of 28 newborns 25 (89%) survived and 3 (11%) of children died due to cardiopulmonary decompensation. Conclusion: Timely diagnoses are of great importance for planning of postnatal care and gathering a multidisciplinary team. Advances in preoperative and postoperative care, and surgical techniques reduce the number of complications and improve survival. For more precise conclusions on this topic research should include wilder population or have a loger time frame.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:512846
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-09-15 12:12:53