OBJECTIVES: Cryoglobulinemias are a group of diseases with serologic presence of cryoglobulins, proteins that precipitate in cold conditions. Mixed cryoglobulinemia (type II and III) appear as primary disorder or secondary to other diseases, most often hematological, autoimmune or infectious. The most common infection accompanied by cryoglobulinemia is chronic hepatitis C, and the most common autoimmune disease is Sjögren's syndrome. The objective of this work was to investigate clinical manifestations in patients with cryoglobulinemia treated by a rheumatologist and to determine whether there is a difference in the described characteristics between mixed cryoglobulinemia at an older and younger age. METHODS AND MATERIALS: We retrogradely investigated medical records from inpatients, polyclinics and daily hospital of the Department of Rheumatology and Clinical Immunology in a 10-year period that had cryoglobulinemia as the leading or associated diagnosis on medical report or the term “cryoglobulinemia” was recorded in the conclusion of discharge letter. Only those patients who had at least two clinical visits recorded during the 10- year follow-up interval were included. RESUSLTS: Through the search, about 21 patients with cryoglobulinemia were recorded, and the majority (18/21) were women. When we divided them according to age, we found that 12 of them were older, and 9 were younger than 60. The majority had an associated autoimmune disease, most commonly systemic lupus erythematosus (SLE). In the older age group, the most common accompanying autoimmune disease was Sjögren's syndrome. In the older group there were significantly more patients with malignant hematological diseases. The subjects in the older group had more often purpura, peripheral nerves involvement and renal involvement, and the average serum level of cryoglobulins was higher in these patients compared to the younger age group. The incidence of hepatitis C was low in both groups. Patients were usually treated with oral glucocorticoids (OGC), disease-modifying drugs, immunosuppressants, and rarely with biological drugs. Subjects ≥60 years of age received OGK, hydroxychloroquine, cyclophosphamide and IVIG largely, while those aged <60 were more often treated with mycophenolate mofetil and biological therapy. CONCLUSIONS: There are no significant differences in the clinical manifestations of mixed cryoglobulinemia between different age groups. In elderly patients, cryoglobulinemia is often a manifestation of a systemic autoimmune disease, especially Sjögren's disease and lymphoproliferative disease. More aggressive immunosuppression and/or biological therapy was applied mainly in younger patients with cryoglobulinemia.