prikaz prve stranice dokumenta The incidence of coinfections and superinfections in COVID-19 patients admitted to the ICU of the Department of Anesthesia, Resuscitation and Intensive Care, University Hospital of Split in 2020
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master's thesis
The incidence of coinfections and superinfections in COVID-19 patients admitted to the ICU of the Department of Anesthesia, Resuscitation and Intensive Care, University Hospital of Split in 2020
2021. urn:nbn:hr:171:560892
Sannaes, Katrine Helgeland
University of Split
School of Medicine

Cite this document

Sannaes, K. H. (2021). The incidence of coinfections and superinfections in COVID-19 patients admitted to the ICU of the Department of Anesthesia, Resuscitation and Intensive Care, University Hospital of Split in 2020 (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:560892

Sannaes, Katrine Helgeland. "The incidence of coinfections and superinfections in COVID-19 patients admitted to the ICU of the Department of Anesthesia, Resuscitation and Intensive Care, University Hospital of Split in 2020." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:560892

Sannaes, Katrine Helgeland. "The incidence of coinfections and superinfections in COVID-19 patients admitted to the ICU of the Department of Anesthesia, Resuscitation and Intensive Care, University Hospital of Split in 2020." Master's thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:560892

Sannaes, K. H. (2021). 'The incidence of coinfections and superinfections in COVID-19 patients admitted to the ICU of the Department of Anesthesia, Resuscitation and Intensive Care, University Hospital of Split in 2020', Master's thesis, University of Split, School of Medicine, accessed 21 October 2024, https://urn.nsk.hr/urn:nbn:hr:171:560892

Sannaes KH. The incidence of coinfections and superinfections in COVID-19 patients admitted to the ICU of the Department of Anesthesia, Resuscitation and Intensive Care, University Hospital of Split in 2020 [Master's thesis]. Split: University of Split, School of Medicine; 2021 [cited 2024 October 21] Available at: https://urn.nsk.hr/urn:nbn:hr:171:560892

K. H. Sannaes, "The incidence of coinfections and superinfections in COVID-19 patients admitted to the ICU of the Department of Anesthesia, Resuscitation and Intensive Care, University Hospital of Split in 2020", Master's thesis, University of Split, School of Medicine, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:171:560892

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Metadata
TitleThe incidence of coinfections and superinfections in COVID-19 patients admitted to the ICU of the Department of Anesthesia, Resuscitation and Intensive Care, University Hospital of Split in 2020
Title (croatian)Incidencija koinfekcija i superinfekcija u bolesnika s COVID-19 primljenih u JIL Klinike za anesteziologiju, reanimatologiju i intenzivno liječenje Kliničkog bolničkog centra Split tijekom 2020. godine
AuthorKatrine Helgeland Sannaes
MentorNenad Karanović (mentor)
Committee memberMihajlo Lojpur (predsjednik povjerenstva)
Committee memberJoško Božić (član povjerenstva)
Committee memberSandro Glumac (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2021-07-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract
Objectives: Investigate the prevalence of pulmonary superinfections in COVID-19 patients on ventilators and the susceptibility of causative microorganisms to antibiotics during 2020 pandemic. To investigate the outcome of coinfected or superinfected patients in a 30-day period, LOS (length of stay) in ICU and hospital Materials and methods: During 2020, 184 patients were admitted to the COVID-19 ICU of the Department of Anesthesia, Resuscitation, & Intensive Care, University Hospital of Split; of these, 181 was included in this study. Three patients were excluded due to incomplete files. The study was conducted as an observational retrospective study. Medical data were collected by reviewing the history and discharge papers in medical files stored in the archive. Results: Out of 181 patients, 102 patients were tested for respiratory coinfection/superinfection. 3.3% of patients had a respiratory coinfection upon admittance, and 44.8% developed a respiratory superinfection. The mean time to develop a respiratory superinfection was 10.9 days, with a median of 10 days after admittance to the hospital. The mean time to develop a respiratory superinfection was 5.3 days, with a median of 4 days after admittance to ICU. Patients with a positive respiratory sample had a statistically significant increase in mortality (p=0.002); they also had a significantly longer stay in Hospital and ICU compared with noninfected patients. The most common etiology of positive respiratory samples was Acinetobacter baumannii, Candida albicans, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Conclusion: The prevalence of pulmonary superinfections in patients in the ICU was 44.8%. The most common causative microorganisms of pulmonary coinfection/superinfection were MDR Acinetobacter baumannii, Candida albicans, MDR Pseudomonas aeruginosa, and Klebsiella pneumoniae. Patients with a respiratory coinfection/superinfection had statistically significantly higher mortality than patients without respiratory coinfection/superinfection.
Abstract (croatian)
Ciljevi: Istražiti prevalenciju plućnih superinfekcija u bolesnika s COVID-19 na strojnoj ventilaciji i osjetljivost uzročnih mikroorganizama na antibiotike tijekom 2020. U cilju istraživanja ishoda bolesnika zaraženih korona virusom ili bolesnika sa superinfekcijama u razdoblju od 30 dana. Također je istraživana duljina boravka/liječenja (LOS) na intenzivnoj njezi i u bolnici. Materijali i metode: Tijekom 2020. godine na intenzivnoj njezi COVID-19 Klinike za anesteziologiju, reanimatologiju i intenzivno liječenje KBC-a Split primljena su 184 pacijenta; od toga je 181 bio uključen u ovu studiju. Tri bolesnika su isključena zbog nepotpunih podataka. Istraživanje je provedeno kao opservacijska retrospektivna studija. Medicinski podaci prikupljeni su pregledom povijesti bolesti i otpusnim pismima u medicinskim datotekama pohranjenim u arhivi. Rezultati: Od 181 bolesnika, 102 bolesnika testirana su na respiratornu coinfekciju/superinfekciju. 3.3% bolesnika imalo je respiratornu infekciju nakon prijema, a 44.8% respiratornu superinfekciju. Srednje vrijeme za razvoj respiratorne superinfekcije bilo je 10.9 dana, s medijanom od 10 dana nakon prijema u bolnicu. Srednje vrijeme za razvoj respiratorne superinfekcije bilo je 5.3 dana, s medijanom od 4 dana nakon prijema na intenzivnu. Bolesnici s pozitivnim respiratornim uzorkom imali su statistički značajno povećanje smrtnosti (p=0.002); također su imali znatno duži boravak u bolnici i intenzivnoj njezi u usporedbi s nezaraženim pacijentima. Najčešća etiologija pozitivnih respiratornih uzoraka bila je Acinetobacter baumannii, Candida albicans, Pseudomonas aeruginosa i Klebsiella pneumoniae. Zaključak: Prevalencija plućnih superinfekcija u bolesnika na intenzivnoj njezi iznosila je 44,8%. Najčešći uzročni mikroorganizmi plućne coinfekcije/superinfekcije bili su MDR Acinetobacter baumannii, Candida albicans, MDR Pseudomonas aeruginosa i Klebsiella pneumoniae. Bolesnici s respiratornom coinfekcijom/superinfekcijom imali su statistički značajno veću smrtnost od bolesnika bez respiratorne coinfekcije/superinfekcije.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:560892
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-03 08:18:28