Objectives: The growing market of the herbal products is not accompanied with an increase in their safety and efficacy in patients. Furthermore, herbal products can cause adverse drug reactions as well as conventional therapy and it is necessary to report any suspected adverse drug reaction of this group of drugs. The aim of this research was to assess the knowledge of herbal products in pharmacy, dental and medical students, and their use of high-quality sources of information. Also, this study includes the number and characteristics of reports of suspected adverse reactions to herbal products to the Agency for Medicinal Products and Medical Devices (HALMED) in the period from 2008 to 2017 and the diversity of herbal product registrations and Patient information leaflet for ginkgo, milk-thistle, St. John's wort and ginseng in Great Britain, Germany, Croatia and Bosnia and Herzegovina. Methods: The research in students of pharmacy, dental medicine and medicine was organized as a cross-sectional survey study. Data on spontaneously reported suspected adverse reactions to over-the-counter and herbal products were obtained from HALMED and analyzed according to the year of report, reporter, sex and age of patient, severity, active substance, number of concomitant medications and System Organ Classes according to Medical dictionary for Regulatory Activities. The Patient information leaflet on the medicinal products of registered herbal medicines in United Kingdom, Germany, Croatia and Bosnia and Herzegovina were compared with herbal monographs of ginkgo leaf, milk-thistle fruit, St. John's wort and ginseng root. Results: The study involved 506 students at the University of Split School of Medicine who completed the questionnaire. Compared to students of all study programs and all years of study, the highest level of knowledge was shown by fifth year pharmacy students. Compared to medical students (7%), pharmacy students (3%) and dental medicine students (2%) used the results of randomized controlled clinical trials less frequently as a source of information on dietary supplements (p=0.045). The largest share of reports of suspected adverse drug reactions of herbal products was received in the period from 2013 to 2017, 73%. As for other over-thecounter drugs, the largest number of suspected adverse drug reactions of herbal products were reported by pharmacists (42%). The Patient information leaflet for the registered herbal products of ginkgo leaf, milk-thistle fruit and St. John's wort in the United Kingdom fully complied with the regulations of EU herbal monographs, while in Germany, Croatia and Bosnia and Herzegovina not all herbal products of ginkgo leaf, milk-thistle fruit, St. John's wort and ginseng root registered on the market were registered according to the regulations of EU herbal monographs. Conclusions: This study has shown that pharmacy students have higher levels of knowledge about herbal products, compared to dental and medical students. However, compared to medical students, pharmacy students are less likely to use the results of randomized controlled clinical trials or systematic reviews as sources of information on herbal products. Furthermore, despite the shortcomings in the education of pharmacy students, the research showed that pharmacists are the most frequent reporters of suspected adverse drug reactions for herbal products in Croatia. Furthermore, the study has shown that the Patient information leaflet available in herbal products in the included countries was not in line with EU herbal monographs and that herbal products of ginkgo leaf, milk-thistle fruit, St. John's wort and ginseng root were differently registered on the market.