| Abstract | Cilj istraživanja: Odrediti prevalenciju metaboličkog sindroma u populaciji djece i
adolescenata u Dalmaciji, te odrediti prevalenciju određenih kliničkih i biokemijskih
odrednica metaboličkog sindroma.
Materijal i metode: Istraživanje je provedeno na uzorku od 201 ispitanika srednje dobi 13,1
± 2,7 godina. Pretilost je temeljni kriterij uključenja u istraživanje. S obzirom na značajke
ispitane populacije, ovisne od dobi i spolu, pretilost je definirana prema BMI-SDS, gdje je
granična vrijednost za postavljanje dijagnozu pretilosti B I-SDS 2 i veći. Istraživanje se
provodi retrospektivnom presječnom analizom iz medicinske dokumentacije pismohrane
Klinike za dječje bolesti KBC-a Split, koje je odobreno od strane Etičkog povjerenstva KBC-a Split.
Rezultati: Od ukupno 201 ispitanika, 31,85 % imalo je kriterije za MetS, a 68,16% nije
imalo kriterije za MetS. Hipertrigliceremiju ima 49 (24,4%) ispitanika, sniženu vrijednost
HDL ima 56 (27,8%) ispitanika, hiperglikemiju na tašte ima 17 (8,5%), povišenu HOMA indeks za procjenu inzulinske rezistencije ima 97 (48,2%) ispitanika, hiperinzulinemiju na tašte ima 99 (49,3%) pacijenata, povišeni sistolički tlak ima 78 (38,8%) ispitanika, povišeni dijastolički tlak ima 21 (10,4%) ispitanik. Statistički značajna razlika nađena u korelaciji između HOMA indeksa i BMI-SDS p=0,05.
Zaključci: Prevalencija metaboličkog sindroma iznosi 31,85%, što je veća prevalencija od
većine europskih studija. Unatoč hiperinzulinemiji i inzulinskoj rezistenciji, prosječne
vrijednosti glukoze na tašte bile su normalne u obje skupine, što odražava raspon poremećaja
metabolizma glukoze u pretilih osoba. Iz navedenih zaključujemo da se poremećena
tolerancija glukoze razvija kasnije u odnosu na ostale odrednice MetS, dok je inzulinska
rezistencija raniji i dominantniji poremećaj. |
| Abstract (english) | Aim of study: To determine the prevalence of metabolic syndrome in obese children and
adolescents in Dalmatia, and to determine prevalence of certain clinical and biochemical
characteristics of the metabolic syndrome.
Materials and methods: Our study included 201 obese patients, average age 13.1 ± 2.7
years. Obesity is a criteria of inclusion in the study. Considering the characteristics of the
tested population, depending on age and gender, obesity is defined by BMI-SDS, where the
threshold for the diagnosis of obesity is BMI-SDS above 2. Research was accomplished by
retrospective cross-sectional analysis of medical records of Department of Pediatrics at
University Hospital Split, which was approved by the Ethics Committee of University
Hospital Split.
Results: Of the 201 patients, 31.85% have met criteria for metabolic syndrome.
Hypertriglyceridemia had 49 (24.4%) patients, decreased values of HDL had 56 (27.8%)
patients, fasting hyperglycemia had 17 (8.5%), elevated HOMA index to assess insulin
resistance had 97 (48.2%) of patients, fasting hyperinsulinemia had 99 (49.3%) patients,
elevated systolic blood pressure had 78 (38.8%) patients, elevated diastolic pressure had 21
(10.4%) patients. Statisticly significant difference was found in the correlation between
HOMA index and BMI-SDS, P = 0.05.
Conclusion:The prevalence of metabolic syndrome was 31.85%, which is higher prevalence
of many European studies. Despite hyperinsulinemia and insulin resistance, the average
fasting glucose were normal in both groups, reflecting a range of disorders in glucose
metabolism in obese individuals. From the above, we conclude that the impaired glucose
tolerance develops later than other components of metabolic syndrome, while insulin
resistance is early and dominant disorder. |
