prikaz prve stranice dokumenta Clinical and demographical features of adult patients with acute intoxication admitted to a medical intensive care unit
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master's thesis
Clinical and demographical features of adult patients with acute intoxication admitted to a medical intensive care unit
2023. urn:nbn:hr:171:089297
Kvartuč, Lukas
University of Split
School of Medicine

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Kvartuč, L. (2023). Clinical and demographical features of adult patients with acute intoxication admitted to a medical intensive care unit (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:089297

Kvartuč, Lukas. "Clinical and demographical features of adult patients with acute intoxication admitted to a medical intensive care unit." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:089297

Kvartuč, Lukas. "Clinical and demographical features of adult patients with acute intoxication admitted to a medical intensive care unit." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:089297

Kvartuč, L. (2023). 'Clinical and demographical features of adult patients with acute intoxication admitted to a medical intensive care unit', Master's thesis, University of Split, School of Medicine, accessed 24 October 2024, https://urn.nsk.hr/urn:nbn:hr:171:089297

Kvartuč L. Clinical and demographical features of adult patients with acute intoxication admitted to a medical intensive care unit [Master's thesis]. Split: University of Split, School of Medicine; 2023 [cited 2024 October 24] Available at: https://urn.nsk.hr/urn:nbn:hr:171:089297

L. Kvartuč, "Clinical and demographical features of adult patients with acute intoxication admitted to a medical intensive care unit", Master's thesis, University of Split, School of Medicine, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:171:089297

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Metadata
TitleClinical and demographical features of adult patients with acute intoxication admitted to a medical intensive care unit
Title (croatian)Kliničke i demografske osobitosti akutno otrovanih odraslih bolesnika u internističkoj intenzivnoj jedinici
AuthorLukas Kvartuč
MentorVedran Kovačić (mentor)
Committee memberIvana Mudnić (predsjednik povjerenstva)
Committee memberTina Tičinović Kurir (član povjerenstva)
Committee memberMarino Vilović (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2023-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Intensive Care
Abstract
Objectives: The objective of study was to assess the demographics, clinical parameters and outcome of acute intoxications among adult patients admitted in medical ICU (intensive care unit) in southern Croatia. Subjects and Methods: An observational retrospective study was conducted during one-year period. Subjects were patients admitted to the ICU due to acute poisoning. Results: 81 subjects (32.1% females) aged 43.16±14.77 years were admitted in ICU due poisoning (14.97% of total annual ICU admissions). Psychiatric disorders were previously established in 76.5%, and 69.1% of all acute intoxications were classified as suicidal. Non-suicidal subjects differed from suicidal subjects in age (37.36±9.71 vs. 45.75±15.93 years; P=0.009), in pCO2 (6.38±1.78 vs. 5.50±1.26 kPa; P=0.020), in length-of-stay in ICU (median 1.00, interquartile range 1.00 vs. median 2.00, interquartile range 2.00 days; P = 0.022) and in length-of-stay in hospital (median 2.00, interquartile range 2.00 vs. median 10.50, interquartile range 15.25 days; P =<0.001). Three (3.7%) patients died. Pharmaceutical psychoactive drug intoxication was the most common cause of acute intoxication, of these, diazepam was the most frequent (16.8%), followed by ethanol (9.0%) and alprazolam (7.8%). Benzodiazepines/hypnotics class was the most common group (28.7%), followed by antipsychotics (13.2%). The largest number of cases were intoxications with more than one poison (67.9%). Toxins number was significantly negatively correlated with length-of-stay in hospital (rho=-0.265; P =0.008), systolic blood pressure (rho=-0.318; P =0.002) and diastolic blood pressure (rho=-0.262; P =0.009). Electrocardiogram was considered abnormal in 50.62%. Conclusion: The most common agents of acute intoxications were psychiatric pharmaceutical drugs. Multidrug exposure was a typical pattern of acute intoxication and was correlated with arterial hypotension at admission time.
Abstract (croatian)
Cilj istraživanja: Cilj ovog istraživanja bio je procijeniti demografske i kliničke osobitosti, te ishode akutnih intoksikacija kod odraslih bolesnika primljenih u internistički JIL (jedinicu intenzivnog liječenja) u južnoj Hrvatskoj. Ispitanici i metode: Opservacijska retrospektivna studija provedena je tijekom jednogodišnjeg razdoblja. Ispitanici su bili odrasli bolesnici primljeni u internističku jedinicu intenzivnog liječenja zbog akutnog trovanja. Rezultati: 81 ispitanik (32.1% žena) u dobi od 43.16±14.77 godina primljen je u JIL zbog trovanja (14.97% od svih godišnjih prijema u JIL). Psihijatrijski poremećaji prethodno su utvrđeni u 76.5% ispitanika, a 69.1% svih akutnih intoksikacija klasificirano je kao suicidalno. Nesuicidalni ispitanici razlikovali su se od suicidalnih po dobi (37.36±9.71 naspram 45.75±15.93 godina; p=0.009), po pCO2 (6.38±1.78 naspram 5.50±1.26 kPa; P=0.020), po duljini boravka u JIL (medijan 1.00, interkvartilni raspon 1.00 naspram medijan 2.00, interkvartilni raspon 2.00 dana; P = 0.022) i u duljini boravaka u bolnici (medijan 2.00, interkvartilni raspon 2.00 vs. medijan 10.50, interkvartilni raspon 15.25 dana; P =<0.001). Tri (3.7%) bolesnika su umrla. Trovanje psihoaktivnim lijekovima je najčešći uzrok akutne intoksikacije, od čega je najčešći bio diazepam (16.8%), zatim etanol (9.0%) i alprazolam (7.8%). Najčešća skupina bili su benzodiazepini/hipnotici (28.7%), a zatim antipsihotici (13.2%). Najveći broj slučajeva bile su intoksikacije s više od jednog otrova (67.9%). Broj toksina značajno je negativno korelirao s duljinom boravka u bolnici (rho=-0.265; P =0.008), sistoličkim krvnim tlakom (rho=-0.318; P =0.002) i dijastoličkim krvnim tlakom (rho=-0.262; P =0.009). Elektrokardiogram se smatra abnormalnim u 50.62%. Zaključci: Najčešći uzročnici akutnih intoksikacija bili su psihijatrijski lijekovi. Trovanje sa više tvari bilo je tipičan obrazac akutne intoksikacije te je bilo udruženo sa arterijskom hipotenzijom u trenutku prijema.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:089297
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-07-06 08:30:17