prikaz prve stranice dokumenta Retrospective analysis of stereotactic radiotherapy for primary intrapulmonary lesions
  Download
PDF 888.04 KB
master's thesis
Retrospective analysis of stereotactic radiotherapy for primary intrapulmonary lesions
2023. urn:nbn:hr:171:674103
Valentini, Justus
University of Split
School of Medicine

Cite this document

Valentini, J. (2023). Retrospective analysis of stereotactic radiotherapy for primary intrapulmonary lesions (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:674103

Valentini, Justus. "Retrospective analysis of stereotactic radiotherapy for primary intrapulmonary lesions." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:674103

Valentini, Justus. "Retrospective analysis of stereotactic radiotherapy for primary intrapulmonary lesions." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:674103

Valentini, J. (2023). 'Retrospective analysis of stereotactic radiotherapy for primary intrapulmonary lesions', Master's thesis, University of Split, School of Medicine, accessed 29 April 2024, https://urn.nsk.hr/urn:nbn:hr:171:674103

Valentini J. Retrospective analysis of stereotactic radiotherapy for primary intrapulmonary lesions [Master's thesis]. Split: University of Split, School of Medicine; 2023 [cited 2024 April 29] Available at: https://urn.nsk.hr/urn:nbn:hr:171:674103

J. Valentini, "Retrospective analysis of stereotactic radiotherapy for primary intrapulmonary lesions", Master's thesis, University of Split, School of Medicine, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:171:674103

Please login to the repository to save this object to your list.
Metadata
TitleRetrospective analysis of stereotactic radiotherapy for primary intrapulmonary lesions
Title (croatian)Retrospektivna analiza stereotaktičke radioterapije za primarne intrapulmonalne lezije
AuthorJustus Valentini
MentorGeorg Gerhard Grabenbauer (mentor)
Committee memberPeter Georg Dahlem (predsjednik povjerenstva)
Committee memberIris Jerončić Tomić (član povjerenstva)
Committee memberMarino Vilović (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2023-07-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Radiotherapy and Oncology
Abstract
Objectives: The objective of this retrospective study was to evaluate the outcomes of patients with early-stage lung cancer that were treated by stereotactic radiotherapy. Endpoints included overall survival, local control, local progression-free survival and their possible prognostic factors as well as quality of life data. Materials and methods: Between 2014 and 2021, a total of 51 patients meeting the inclusion criteria were evaluated. All patients have been treated by stereotactic radiotherapy using either 3 x 12.5-15 Gy, 8 x 7.5 Gy, or 12 x 4-6 Gy. Treatment planning was carried out using the EclipseTM treatment planning system v18.0 (Varian Medical Systems). All radiation treatments were performed using the advanced radiation equipment of a TruebeamTM 2.0-linear accelerator with a 6-degree of freedom couch (Varian Medical Systems). Surviving patients were requested to complete the EORTC QLQ-C30 and QLQ-LC29 questionnaires to evaluate their quality of life (QoL) in order to assess patient reported outcome measures (PROMs). Results: The actuarial 1-year, 2-year, 3-year, and 5-year OS rates were 77%, 61%, 46%, and 26%, respectively. The 1-year, 2-year, and 3-year LC rates were 91%, 91%, and 76%, respectively. Independent prognostic factors with positive impact on OS were female gender (HR: 0.273; P=0.008), and previous lung surgery (HR: 0.378; P=0.028). In terms of QoL, a very poor global health status together with low functional scales including role function, and social function as well as leading symptom scales of dyspnea and fatigue are being reported by the surviving patient cohort. Conclusion: Stereotactic radiotherapy for early lung cancer proved to be a very effective and safe treatment.
Abstract (croatian)
Ciljevi: Cilj ove retrospektivne studije bio je procijeniti ishode liječenja u bolesnika s ranim stadijem karcinoma pluća koji su liječeni stereotaktičkom radioterapijom. Kao krajnji ciljevi su uzeti opće preživljenje, lokalna kontrola, lokalno preživljenje bez progresije te njihovi mogući prognostički faktori, kao i podaci o kvaliteti života. Materijali i metoda: Od 2014. do 2021. godine procijenjen je ukupno 51 bolesnik koji ispunjavaju uključne kriterije. Svi bolesnici liječeni su stereotaktičkom radioterapijom koristeći doze od 3 x 12,5-15 Gy, 8 x 7,5 Gy ili 12 x 4-6 Gy. Planiranje liječenja provedeno je pomoću sustava za planiranje liječenja EclipseTM verzije 18.0 (Varian Medical Systems). Radioterapija je izvedena korištenjem napredne radijacijske opreme TruebeamTM 2.0 - linearni akcelerator s kaučom s 6 stupnjeva slobode (Varian Medical Systems). Bolesnicima koji su preživjeli zatraženo je da ispune upitnike EORTC QLQ-C30 i QLQ-LC29 kako bi se procijenila njihova kvaliteta života i rezultati prijavljeni od strane pacijenta. Rezultati: Aktuarske stope preživljenja u razdoblju od 1 godine, 2 godine, 3 godine i 5 godina iznosile su redom 77%, 61%, 46% i 26%. Stope lokalne kontrole u razdoblju od 1 godine, 2 godine i 3 godine iznosile su redom 91%, 91% i 76%. Neovisni prognostički faktori s pozitivnim utjecajem na preživljenje bili su ženski spol (HR: 0.273; P=0.008) i prethodna plućna operacija (HR: 0.378; P=0.028). Što se tiče kvalitete života, vrlo loš opći status zdravlja zajedno s niskim funkcionalnim skalama, uključujući ulogu u funkcioniranju i društvenu funkciju, kao i vodeće simptomatske skale dispneje i umora, prijavljuje se u preživjeloj skupini pacijenata. Zaključci: Stereotaktička radioterapija za rani karcinom pluća pokazala se vrlo učinkovitom i sigurnom terapijom.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:674103
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-07-14 07:27:53