| Abstract | Cilj istraživanja: Cilj ovog istraživanja je utvrditi kvalitetu sažetaka randomiziranih
kontroliranih istraživanja u pacijenata s ulceroznim kolitisom te pobliže opisati mogućnosti
liječenja ulceroznog kolitisa.
Materijal i metode: U izradi ovog diplomskog rada korišteni su sažetci randomiziranih
kontroliranih istraživanja u pacijenata s ulceroznim kolitisom koji su dostupni na MEDLINE
bazi podataka. Rad je napisan u obliku presječne studije u kojoj je analizirana kvaliteta
sažetaka prema smjernicama CONSORT-a.
Rezultati: Pretragom radova pronađena su 273 rada od kojih je, uzimajući u obzir određene
kriterije, u dajnju analizu ušlo njih 136. Niti jedan rad nije sadržavao svih 17 stavki
CONSORT-A liste, dok je više od polovice radova obuhvaćalo minimalno polovinu stavki
CONOSORT-A smjernica. Stavke s najvećom učestalosti su jasno navedene intervencije
(94,9%) i cilj (86,8%) , dok su one s najmanjom sudionici, randomizacija, status istraživanja
te izvor financija. Uspoređujući učestalost CONSORT stavki između sažetaka čije je
istraživanje multicentrično odnosno jednocentrično dokazana je statistički značajna razlika s
vrijednošću p<0,05 za tri stavke (autori, dizajn istraživanja i raspodjela sudionika) dok su
naslov intervencije, cilj i status istraživanja stavke bez statistički značajne razlike s
vrijednošću p>0,05.
Zaključak: Uzimajući u obzir smjernice CONSORT-A liste, sažetci na temu ulceroznog
kolitisa koji su obrađivani u ovom radu umjerene su kvalitete. Potrebno je poboljšanje kako bi
se čitateljima osigurali sažetci koji odlikuju transparentnošću i pružaju nova, vjerodostojna
saznanja. |
| Abstract (english) | Objectives: The aim of this study was to assess the quality of abstracts of randomized
controlled clinical trials in patients with ulcerative colitis and describe all treatment options
for ulcerative colitis.
Materials and methods: Abstracts of randomized controlled trials in patients with ulcerative
colitis, which are available on the PubMed database, were used in the preparation of this
thesis. It was written in the form of a cross-sectional study in which the quality of abstracts
was analyzed according to the CONSORT guidelines.
Results: A search of abstracts found 273 papers, of which, taking certain criteria into account,
136 were included in the present analysis. Not a single abstract contained all 17 items of the
CONSORT-A list, while more than half of the abstracts included at least half of the
CONSORT-A guideline's items. The items with the highest frequency have clearly stated
interventions (94,9%) and the goal (86,8%), while those with the lowest frequency are
participants, randomization, research status and source of funding. Comparing the frequency
of CONSORT items between abstracts whose research is multicenter or single-center, a
statistically significants difference with a value of p<0,05 was demonstrated for three items
(authors, research design and distribution of participants), while title, interventions, goal and
research status were items without statistical significance significant differences with a value
of p>0,05.
Conclusion: Taking into account the criteria of the CONSORT-A list, the abstracts on the
topic of ulcerative colitis that were discussed in this paper are of moderate quality. There is
clearly room for improvement in order to provide readers with summaries that are transparent
and provide new, credible insights. |
