prikaz prve stranice dokumenta Factors associated with atrial fibrosis among patients with atrial fibrillation
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doctoral thesis
Factors associated with atrial fibrosis among patients with atrial fibrillation
2021. urn:nbn:hr:171:744964
Mahnkopf, Christian
University of Split
School of Medicine

Cite this document

Mahnkopf, C. (2021). Factors associated with atrial fibrosis among patients with atrial fibrillation (Doctoral thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:744964

Mahnkopf, Christian. "Factors associated with atrial fibrosis among patients with atrial fibrillation." Doctoral thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:744964

Mahnkopf, Christian. "Factors associated with atrial fibrosis among patients with atrial fibrillation." Doctoral thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:744964

Mahnkopf, C. (2021). 'Factors associated with atrial fibrosis among patients with atrial fibrillation', Doctoral thesis, University of Split, School of Medicine, accessed 04 April 2025, https://urn.nsk.hr/urn:nbn:hr:171:744964

Mahnkopf C. Factors associated with atrial fibrosis among patients with atrial fibrillation [Doctoral thesis]. Split: University of Split, School of Medicine; 2021 [cited 2025 April 04] Available at: https://urn.nsk.hr/urn:nbn:hr:171:744964

C. Mahnkopf, "Factors associated with atrial fibrosis among patients with atrial fibrillation", Doctoral thesis, University of Split, School of Medicine, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:171:744964

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Metadata
TitleFactors associated with atrial fibrosis among patients with atrial fibrillation
Title (croatian)Razlike u fibrozi atrija po dobi i spolu među pacijentima s atrijskom fibrilacijom
AuthorChristian Mahnkopf
VIAF: 13497582
MentorMarkus Ketteler (mentor)
Committee memberZvonko Rumboldt (predsjednik povjerenstva)
Committee memberLovel Giunio (član povjerenstva)
Committee memberLuka Zaputović (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2021-03-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Aim: Age and female sex are associated with a higher risk of stroke in atrial fibrillation (AF). We sought to determine whether advancing age and female sex are associated with higher atrial fibrosis. Methods and results: We conducted an observational cohort study of patients with AF enrolled in the University of Utah AF Database and a non-AF control group who underwent lategadolinium enhancement magnetic resonance imaging (LGE-MRI) for atrial fibrosis quantification. Participants with... More contraindications for contrast MRI scanning were excluded. Nine hundred and eight consecutive men and women with AF and 15 non-AF controls were included in this study. Left atrial fibrosis increased with age in both men and women with AF. Women with AF (n = 316) were older than men (n = 592): mean age 68.7±11.6 vs. 64.9±11.7 years; P < 0.01, and had higher left atrial fibrosis compared with men 17.5 ± 10.1% vs. 15.3 ± 8.9%; P < 0.001. Women also had a higher prevalence of prior stroke than men (15.8% vs. 6.5%; P < 0.001). Age and sex relationships with atrial fibrosis remained significant in multivariate analysis. Compared with the non-AF control group, patients with AF they had significantly higher atrial fibrosis: 16.0 ± 9.4 vs. 5.5 ± 5.8%; P < 0.001. Conclusions: Advancing age and female sex are associated with a higher burden of atrial fibrosis in patients with AF. Women with a prior history of stroke also have higher fibrosis than women and men without a history of stroke. Advanced fibrosis may explain the female and age association with stroke in AF. Less
Abstract (croatian)
Cilj: Dob i ženski spol povezani su s većim rizikom za moždani udar u osoba s atrijskom fibrilacijom (AF). Željeli smo utvrditi jesu li starija životna dob i ženski spol povezani s višom razinom fibroze atrija. Metode i rezultati: Proveli smo kohortnu studiju u koju smo uključili pacijente s AF koji su bili upisani u bazu podataka na Sveučilištu Utah i kontrolnu skupinu bez AF, koja je podvrgnuta magnetskoj rezonanciji s kasnim gadolinijskim kontrastnim pojačanjem prikaza (engl.... More late-gadolinium enhancement magnetic resonance imaging, LGE-MRI) radi određivanja atrijske fibroze. Osobe s kontraindikacijama za LGE-MRI pretragu su bile isključene. Devet stotina i osam uzastopnih ispitanika muškog i ženskog spola s AF i 15 kontrola bez AF-a bilo je uključeno u ovo istraživanje. Fibroza lijevog atrija se povećavala s dobi i kod muškaraca i kod žena s AF. Žene s AF (n=316) bile su starije od muškaraca (n=592), s prosječnom dobi od 68,7 godina ± 11,6 u odnosu na 64,9 ± 11,7 godina u muškaraca (P<0,001) te su imale višu razinu fibroze lijevog atrija u usporedbi s muškarcima (17,5 ± 10,1% nasuprot 15,3 ± 8,9%; P<0,001). Žene su također imale veću prevalenciju prethodnog moždanog udara u usporedbi s muškarcima (15,8% nasuprot 6,5%; P<0,001). Dob i spol bili su prediktori atrijske fibroze u multivarijatnoj analizi. U usporedbi s kontrolnom skupinom koja nema AF, pacijenti s AF imali su značajno višu razinu atrijske fibroze (16,0 ± 9,4 naspram 5,5 ± 5,8%; P<0,001). Zaključci: Starija životna dob i ženski spol povezani su s većim teretom atrijske fibroze kod pacijenata s AF. Žene koje imaju prethodni moždani udar također imaju i veću razinu atrijske fibroze u usporedbi sa ženama i muškarcima koji nisu imali moždani udar. Uznapredovala fibroza može objasniti povezanost između ženskog spola i starije životne dobi s moždanim udarom kod AF. Less
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:744964
Promotion2024
Study programmeTitle: Evidence-Based Clinical Medicine
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-02-07 08:07:01
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