Introduction: A key feature of the COVID-19 infection is endothelial dysfunction caused by binding of the virus to the ACE2 receptor on endothelial cells, leading to a state of coagulopathy. In the general population, COVID-19 is associated with a high rate of thromboembolic complications, while in pregnancy it increases the risk of preeclampsia, premature birth and other adverse pregnancy outcomes such as miscarriage, stillbirth and early neonatal death. Pregnancy, by itself, is a hypercoagulable state, so it is not surprising that during pregnancy and in the puerperium the infection of COVID-19 can have additional or synergistic risk factors for thrombosis. The above indicates that COVID-19 could be associated with a state of hypercoagulability that results in uteroplacental malperfusion. The RCOG recommends the introduction of LMWH prophylactically for all COVID-19 positive pregnancies, unless delivery is expected within the next 12 hours. The morphological changes on the placenta such as a higher frequency of MVM, FVM and an increase in perivillous fibrin deposition were observed. The pandemic brought about many restrictions, which resulted in difficult provision of medical care to everyone, including pregnant women, which increased the possibility of an unfavorable pregnancy outcomes. Aim: The main aim of the study was to determine the pathohistological characteristics of placentas from COVID-19 pregnancies according to the trimester of primary infection and therapy with low molecular weight heparin. The secondary objectives of the research were to determine whether during the COVID-19 pandemic there was an increase in adverse pregnancy outcomes, such as miscarriages, stillbirths and early neonatal deaths in KBC Split. Matherials and methods: For the first part of the research, 104 placentas and data of mothers who had a positive PCR test for SARS CoV-2 during pregnancy, and who gave birth in the time period from April 1, 2021. until 01.09.2021. in The University Hospital Split, were collected. The placentas were sent for the pathohistological analysis. The collected data were divided into three groups depending on the trimester of pregnancy in which the infection occurred, and then into two groups based on the use of LMWH. The second study included all pregnant women who had an unfavorable pregnancy outcome, such as miscarriage, intrauterine fetal death, as well as early neonatal death in The University Hospital Split. Women were divided into two groups: "before the pandemic" and "during the pandemic", and the data were statistically processed. Results: In 38% of patients the onset of COVID-19 infection was the 1st trimester of pregnancy, in 27% in the 2nd and 35% of women were infected in the 3rd trimester. FVM occurrence was statistically significantly higher in the LMWH− group and if the onset of infection was in the 2nd trimester, while the perivillous fibrin deposition was most likely to happen if the COVID-19 infection occured in the 1st trimester of pregnancy. There was no statistically significant difference in the incidence of adverse pregnancy outcomes in the period prior to the pandemic and during the year of the COVID-19 pandemic. Conclusion: The onset of COVID-19 infection has the influence on trophoblast damage and subsequent morphological appearance of the placenta. LMWH use in COVID positive pregnant women decreases the rate of the FVM in examined placentas. Our study showed that the pandemic did not have a negative effect on pregnant women and their fetuses. There was no increase in miscarriage, intrauterine fetal demise, or perinatal death during the year of the pandemic. Although our initial hypothesis was not confirmed, the study’s results do indicate that the University Hospital of Split was able to provide pregnant women with the high-quality health care, despite the ongoing pandemic and additional restrictions that were introduced. All of which had no adverse effect on the final outcome of their pregnancies.