Objective: Psoriasis is a chronic inflammatory skin disease whose manifestations, in addition to skin involvement, include other unpleasant symptoms such as pain. Recent research has highlighted that the pain associated with psoriasis has so far been insufficiently studied. Therefore, the aim of the studies conducted within this doctoral thesis was to summarize the available evidence on this topic, to analyze outcomes related to pain used in registered clinical trials and to investigate the burden of pain symptoms in psoriasis through the experiences of patients and dermatologists. Methods: A systematic scoping review was used for mapping the literature on psoriasis and pain. In a meta-research study we analyzed all clinical trials of psoriasis interventions registered at ClinicalTrials.gov and the frequency of pain-related outcomes. We also conducted two qualitative studies based on semi-structured interviews with patients with psoriasis and dermatologists from Croatia. Data from qualitative studies were analyzed using interpretive descriptive and thematic analysis using a 4-step method for systematic text summarization. Results: A search of the literature showed that the majority of studies addressed pain in psoriatic arthritis and pain was mentioned in the conclusion of only 21% of the articles. The second study found that only 0.6% of registered clinical trial protocols had pain as a primary outcome and 6.5% as a secondary outcome. Most patients with psoriasis emphasized the impairment of quality of life due to the presence of pain, as well as the importance of taking pain into account during the assessment and treatment of their disease. Dermatologists indicated the need to emphasize the importance of pain associated with psoriasis in clinical practice and the importance of considering pain during the assessment and treatment of these patients. Conclusion: The results of these studies shoud indicate the important place of pain symptoms in patients with psoriasis. Pain in psoriasis should be considered more often in patient assessment and treatment as well as in future research.