prikaz prve stranice dokumenta Incidence of and predictive factors for bacteremia in newborns upon admission to a neonatal intensive care unit level 1 in Germany
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master's thesis
Incidence of and predictive factors for bacteremia in newborns upon admission to a neonatal intensive care unit level 1 in Germany
2024. urn:nbn:hr:171:276497
Wichterich, Luisa
University of Split
School of Medicine

Cite this document

Wichterich, L. (2024). Incidence of and predictive factors for bacteremia in newborns upon admission to a neonatal intensive care unit level 1 in Germany (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:276497

Wichterich, Luisa. "Incidence of and predictive factors for bacteremia in newborns upon admission to a neonatal intensive care unit level 1 in Germany." Master's thesis, University of Split, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:171:276497

Wichterich, Luisa. "Incidence of and predictive factors for bacteremia in newborns upon admission to a neonatal intensive care unit level 1 in Germany." Master's thesis, University of Split, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:171:276497

Wichterich, L. (2024). 'Incidence of and predictive factors for bacteremia in newborns upon admission to a neonatal intensive care unit level 1 in Germany', Master's thesis, University of Split, School of Medicine, accessed 15 December 2024, https://urn.nsk.hr/urn:nbn:hr:171:276497

Wichterich L. Incidence of and predictive factors for bacteremia in newborns upon admission to a neonatal intensive care unit level 1 in Germany [Master's thesis]. Split: University of Split, School of Medicine; 2024 [cited 2024 December 15] Available at: https://urn.nsk.hr/urn:nbn:hr:171:276497

L. Wichterich, "Incidence of and predictive factors for bacteremia in newborns upon admission to a neonatal intensive care unit level 1 in Germany", Master's thesis, University of Split, School of Medicine, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:171:276497

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TitleIncidence of and predictive factors for bacteremia in newborns upon admission to a neonatal intensive care unit level 1 in Germany
Title (croatian)Učestalost i prediktivni čimbenici za bakterijemiju u novorođenčadi nakon prijema u jedinicu intenzivne njege novorođenčadi razine 1 u Njemačkoj
AuthorLuisa Wichterich
MentorPeter Georg Dahlem (mentor)
Committee memberJohannes Brachmann (predsjednik povjerenstva)
Committee memberMarino Vilović (član povjerenstva)
Committee memberDoris Rušić (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2024-07-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract
Introduction: Neonates, or infants within their first 28 days of life, undergo significant physiological changes after birth, which makes them particularly susceptible to infections, in particular, due to their immature immune systems. The focus is on understanding the early onset of sepsis, which is a severe condition caused by bacterial infections that can lead to high morbidity and mortality in neonates. Objectives: The primary aim of the study is to identify the incidence of bacteremia in neonates at the time of NICU Level I admission and to determine the predictive factors that contribute to its occurrence. The study also seeks to test the hypothesis that certain maternal and neonatal factors are significantly associated with the risk of bacteremia. Materials and Methods: Relevant data of 158 neonates born during the study period and their mothers were obtained from their case records. A diagnosis of early onset sepsis was established based on antibiotic treatment duration or positive blood cultures. Statistical analyses, including Mann-Whitney U test, odds ratio, and Fisher's exact test, were utilized to analyze the data. Results: Only one positive blood culture out of 145 tested cultures was positive for streptococcus agalactiae. Antibiotic therapy duration showed 62.0% no therapy, 13.3% therapy <3 days and 24.7% therapy >3 days. CRP and IL-6 were highly significant indicators of neonatal sepsis (CRP: P<0.001; IL-6: P<0.001). Combined CRP and IL-6 showed increased sensitivity (78.7%) and high, but decreased specificity (89.1%). Out of maternal factors CTG pathologies showed the highest significance (P<0.001, OR=20.06), while maternal fever was only marginally significant (P=0.0468). Conclusions: The study concluded that early identification of bacteremia in neonates is crucial for timely treatment and improved outcomes. Specific maternal and neonatal risk factors can help predict the likelihood of bacteremia, aiding in the early diagnosis and management of neonatal sepsis. The findings underscore the importance of vigilant monitoring and appropriate therapeutic interventions in the NICU to mitigate the risks associated with neonatal bacteremia.
Abstract (croatian)
Uvod: Novorođenčad, ili dojenčad unutar prvih 28 dana života, prolazi kroz značajne fiziološke promjene nakon rođenja, što ih čini posebno podložnima infekcijama, osobito zbog nezrelog imunološkog sustava. Fokus je na razumijevanju ranog nastanka sepse, što je ozbiljno stanje uzrokovano bakterijskim infekcijama koje može dovesti do visoke morbidnosti i mortaliteta kod novorođenčadi. Ciljevi: Primarni cilj studije je identificirati učestalost bakterijemije kod novorođenčadi u trenutku prijema na NICU razine I i utvrditi prediktivne čimbenike koji doprinose njenom nastanku. Studija također nastoji testirati hipotezu da su određeni majčinski i neonatalni čimbenici značajno povezani s rizikom od bakterijemije. Materijali i metode: Relevantni podaci o 158 novorođenčadi rođenih tijekom razdoblja studije i njihovim majkama dobiveni su iz njihovih medicinskih kartona. Dijagnoza ranog nastanka sepse postavljena je na temelju trajanja antibiotske terapije ili pozitivnih krvnih kultura. Statističke analize, uključujući Mann-Whitney U test, omjer izgleda i Fisherov egzaktni test, korištene su za analizu podataka. Rezultati: Samo jedna pozitivna krvna kultura od 145 testiranih kultura bila je pozitivna na Streptococcus agalactiae. Trajanje antibiotske terapije pokazalo je da 62.0% nije imalo terapiju, 13.3% je imalo terapiju <3 dana, a 24.7% terapiju >3 dana. CRP i IL-6 bili su vrlo značajni pokazatelji neonatalne sepse (CRP: P<0.001; IL-6: p<0.001). Kombinirani CRP i IL-6 pokazali su povećanu osjetljivost (78.7%) i visoku, ali smanjenu specifičnost (89.1%). Od majčinskih čimbenika, CTG patologije su pokazale najveću značajnost (P<0.001, OR=20.06), dok je majčina groznica bila samo marginalno značajna (P=0.047). Zaključci: Studija je zaključila da je rano prepoznavanje bakterijemije kod novorođenčadi ključno za pravodobno liječenje i poboljšanje ishoda. Specifični majčinski i neonatalni čimbenici mogu pomoći u predviđanju vjerojatnosti bakterijemije, što pomaže u ranoj dijagnozi i upravljanju neonatalnom sepsom. Nalazi naglašavaju važnost budnog praćenja i odgovarajućih terapijskih intervencija u NICU-u kako bi se smanjili rizici povezani s neonatalnom bakterijemijom.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:276497
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-07-23
Terms of useLicence In copyright icon
Created on2024-07-16 11:49:00