Background: Stroke is a leading cause of disability and death globally. Ischemic stroke, the most common type, arises from blocked cerebral vessels. Mechanical thrombectomy is a groundbreaking treatment for certain strokes, significantly improving outcomes when administered swiftly to eligible patients. Methods: This retrospective cohort study investigated the outcomes of mechanical thrombectomy in stroke patients at the University Hospital of Split during 2021 and 2022. The study included 160 patients (70 in 2021, 90 in 2022) who underwent MT following European Stroke Organization guidelines. Patients with suspected acute ischemic stroke (NIHSS >4) underwent NCCT and CTA to identify large vessel occlusion. The MT procedure, guided by interventional radiologists, utilized a NeuronMax device for clot retrieval. Researchers analyzed clinical data, including NIHSS scores, COVID-19 status, and other baseline variables, to assess patient outcomes. Recovery was evaluated using the modified Rankin Scale post-treatment. Results: No significant differences in baseline demographics or clinical variables were found between 2021 and 2022. The most common pre-existing conditions were atrial fibrillation and hypertension, with a notable minority of patients testing positive for COVID-19 upon admission. The most frequent site of large vessel occlusion was the middle cerebral artery M1 segment. Older age and higher blood glucose levels were associated with poorer functional outcomes (higher mRS scores). Achieving successful reperfusion (higher TICI score) was associated with better outcomes in 2021. While no statistical difference was found in overall TICI or mRS scores between the two years, TICI 3 was the most common reperfusion outcome, while mRS 6 (death) was the most frequent functional outcome. Conclusion: This study identified age, gender, and blood glucose as significant predictors of posttreatment outcomes in acute ischemic stroke patients treated with mechanical thrombectomy. While hypertension and atrial fibrillation were highly prevalent, they did not significantly impact outcomes. This discrepancy highlights the influence of methodological variations on study findings. Despite high rates of successful recanalization, overall functional outcomes (mRS) were poor, emphasizing the need for continued refinement of MT techniques, identification of novel prognostic biomarkers, and a strong emphasis on primary stroke prevention.